WDR47 Gene (Protein Coding)

WD Repeat Domain 47

GC01M108970
GIFtS:
34
See more...

Aliases for WDR47 Gene

Aliases for WDR47 Gene

  • WD Repeat Domain 47 2 3 5
  • Nemitin 2 3 4
  • Neuronal Enriched MAP-Interacting Protein 3 4
  • WD Repeat-Containing Protein 47 3 4
  • KIAA0893 2 4
  • WDR47 5

External Ids for WDR47 Gene

Previous GeneCards Identifiers for WDR47 Gene

  • GC01M109225
  • GC01M109314
  • GC01M109512
  • GC01M107405

Summaries for WDR47 Gene

GeneCards Summary for WDR47 Gene

WDR47 (WD Repeat Domain 47) is a Protein Coding gene. Diseases associated with WDR47 include Lissencephaly.

Gene Wiki entry for WDR47 Gene

Additional gene information for WDR47 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR47 Gene

Genomics for WDR47 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for WDR47 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR47 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR47

Top Transcription factor binding sites by QIAGEN in the WDR47 gene promoter:
  • aMEF-2
  • AML1a
  • FOXI1
  • HFH-3
  • MEF-2
  • MEF-2A
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • SEF-1 (1)

Genomic Locations for WDR47 Gene

Latest Assembly
chr1:108,970,211-109,042,113
(GRCh38/hg38)
Size:
71,903 bases
Orientation:
Minus strand

Previous Assembly
chr1:109,512,836-109,584,724
(GRCh37/hg19 by Entrez Gene)
Size:
71,889 bases
Orientation:
Minus strand

chr1:109,512,836-109,584,850
(GRCh37/hg19 by Ensembl)
Size:
72,015 bases
Orientation:
Minus strand

Genomic View for WDR47 Gene

Genes around WDR47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR47 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WDR47 Gene

Proteins for WDR47 Gene

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  • Protein details for WDR47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94967-WDR47_HUMAN
    Recommended name:
    WD repeat-containing protein 47
    Protein Accession:
    O94967
    Secondary Accessions:
    • A8MX09
    • Q5TYV7
    • Q5TYV8
    • Q5TYV9
    • Q8IXT7
    • Q8IYU9

    Protein attributes for WDR47 Gene

    Size:
    919 amino acids
    Molecular mass:
    101949 Da
    Quaternary structure:
    • Interacts with MAP1S (via WD repeats).
    SequenceCaution:
    • Sequence=AK225781; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA74916.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR47 Gene

Protein Expression for WDR47 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WDR47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR47 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR47 Gene

Domains & Families for WDR47 Gene

Gene Families for WDR47 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR47 Gene

InterPro:
Blocks:
  • CTLH, C-terminal to LisH motif
  • Lissencephaly type-1-like homology motif
ProtoNet:

Suggested Antigen Peptide Sequences for WDR47 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat-containing protein 47 (WDR47_HUMAN)
genes like me logo Genes that share domains with WDR47: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR47 Gene

Function for WDR47 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Phenotypes From GWAS Catalog for WDR47 Gene

Gene Ontology (GO) - Molecular Function for WDR47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with WDR47: view
genes like me logo Genes that share phenotypes with WDR47: view

Animal Models for WDR47 Gene

MGI Knock Outs for WDR47:
  • Wdr47 Wdr47<tm1a(EUCOMM)Wtsi>

Animal Models for research

miRNA for WDR47 Gene

miRTarBase miRNAs that target WDR47

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR47

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR47 Gene

Localization for WDR47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR47 Gene

Cytoplasm, cytoskeleton. Note=Localization along microtubules is mediated by MAP1S. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR47 gene
Compartment Confidence
cytoskeleton 4
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with WDR47: view

Pathways & Interactions for WDR47 Gene

PathCards logo

SuperPathways for WDR47 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with WDR47: view

No data available for Pathways by source and SIGNOR curated interactions for WDR47 Gene

Drugs & Compounds for WDR47 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for WDR47 Gene

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  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for WDR47 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR47

Alternative Splicing Database (ASD) splice patterns (SP) for WDR47 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for WDR47 Gene

GeneLoc Exon Structure for
WDR47

Expression for WDR47 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR47 Gene

mRNA expression in normal human tissues for WDR47 Gene
mRNA expression by BioGPS for WDR47 GenemRNA expression by GTEx for WDR47 Gene

mRNA differential expression in normal tissues according to GTEx for WDR47 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for WDR47 Gene

This gene is overexpressed in Fetal Brain (30.0), Frontal cortex (20.2), and Brain (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR47 Gene



Protein tissue co-expression partners for WDR47 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR47

SOURCE GeneReport for Unigene cluster for WDR47 Gene:

Hs.570055

Evidence on tissue expression from TISSUES for WDR47 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with WDR47: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR47 Gene

Orthologs for WDR47 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR47 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia WDR47 30 31
  • 99.82 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia WDR47 30 31
  • 94.35 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia WDR47 30 31
  • 94.2 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Wdr47 30 17 31
  • 90.22 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Wdr47 30
  • 89.24 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia WDR47 31
  • 74 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia WDR47 31
  • 57 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves WDR47 30 31
  • 81.77 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia WDR47 31
  • 90 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia wdr47 30
  • 71.93 (n)
Zebrafish
(Danio rerio)
 Actinopterygii wdr47b 31
  • 71 (a)
 OneToMany
wdr47a 30 31
  • 68.61 (n)
 OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.14134 30
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006113 30
  • 55.08 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta CG2812 30 31
  • 54.05 (n)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea nmtn-1 30 31
  • 52.24 (n)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes STE4 31
  • 20 (a)
 OneToMany
Species where no ortholog for WDR47 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WDR47 Gene

ENSEMBL:
Gene Tree for WDR47 (if available)
TreeFam:
Gene Tree for WDR47 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR47: view image

Paralogs for WDR47 Gene

No data available for Paralogs for WDR47 Gene

Variants for WDR47 Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for WDR47 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for WDR47 Gene

Variant ID Type Subtype PubMed ID
dgv490n54 CNV loss 21841781
dgv491n54 CNV gain 21841781
dgv492n54 CNV loss 21841781
dgv493n54 CNV gain+loss 21841781
dgv494n54 CNV loss 21841781
dgv495n54 CNV loss 21841781
dgv60e199 CNV deletion 23128226
dgv64n67 CNV loss 20364138
esv2658750 CNV deletion 23128226
esv2676133 CNV deletion 23128226
esv27754 CNV loss 19812545
esv2798 CNV loss 18987735
esv32817 CNV loss 17666407
esv3567248 CNV deletion 23714750
esv3587144 CNV loss 21293372
esv3587145 CNV loss 21293372
nsv1137794 CNV deletion 24896259
nsv437236 CNV loss 16327808
nsv547425 CNV gain 21841781
nsv547426 CNV loss 21841781
nsv547427 CNV loss 21841781
nsv547428 CNV loss 21841781
nsv547433 CNV gain+loss 21841781
nsv547440 CNV gain+loss 21841781
nsv547460 CNV loss 21841781
nsv547466 CNV gain 21841781
nsv547467 CNV loss 21841781
nsv823954 CNV loss 20364138
nsv823987 CNV loss 20364138
nsv831026 CNV loss 17160897
nsv946127 CNV duplication 23825009
nsv946128 CNV duplication 23825009
nsv956243 CNV deletion 24416366

Variation tolerance for WDR47 Gene

Residual Variation Intolerance Score: 6.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR47 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR47

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR47 Gene

Disorders for WDR47 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR47 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
lissencephaly
- elite association - COSMIC cancer census association via MalaCards
Search WDR47 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR47

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with WDR47: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR47 Gene

Publications for WDR47 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  2. Nemitin, a novel Map8/Map1s interacting protein with Wd40 repeats. (PMID: 22523538) Wang W … Yang Y (PloS one 2012) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair. (PMID: 31024071) Guard SE … Old WM (Scientific reports 2019) 3
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3

ExternalLinks

View latest publications for WDR47 gene in Mastermind

Products for WDR47 Gene

Sources for WDR47 Gene