Aliases for WDR43 Gene
External Ids for WDR43 Gene
Previous GeneCards Identifiers for WDR43 Gene
GeneCards Summary for WDR43 Gene
WDR43 (WD Repeat Domain 43) is a Protein Coding gene. Diseases associated with WDR43 include Orofacial Cleft 15 and Acrofacial Dysostosis, Cincinnati Type. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is MAPKBP1.
UniProtKB/Swiss-Prot Summary for WDR43 Gene
Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity).