This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal tran... See more...

Aliases for WDR37 Gene

Aliases for WDR37 Gene

  • WD Repeat Domain 37 2 3 5
  • WD Repeat-Containing Protein 37 3 4
  • KIAA0982 4
  • NOCGUS 3

External Ids for WDR37 Gene

Previous GeneCards Identifiers for WDR37 Gene

  • GC10P001056
  • GC10P001085
  • GC10P001092
  • GC10P001041
  • GC10P001095

Summaries for WDR37 Gene

Entrez Gene Summary for WDR37 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR37 Gene

WDR37 (WD Repeat Domain 37) is a Protein Coding gene. Diseases associated with WDR37 include Neurooculocardiogenitourinary Syndrome and Coloboma Of Macula. An important paralog of this gene is WDR12.

Gene Wiki entry for WDR37 Gene

Additional gene information for WDR37 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR37 Gene

Genomics for WDR37 Gene

GeneHancer (GH) Regulatory Elements for WDR37 Gene

Promoters and enhancers for WDR37 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR37 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR37

Top Transcription factor binding sites by QIAGEN in the WDR37 gene promoter:
  • aMEF-2
  • CUTL1
  • Elk-1
  • Hlf
  • Lhx3a
  • LHX3b
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2

Genomic Locations for WDR37 Gene

Genomic Locations for WDR37 Gene
chr10:1,049,538-1,132,384
(GRCh38/hg38)
Size:
82,847 bases
Orientation:
Plus strand
chr10:1,095,478-1,178,237
(GRCh37/hg19)
Size:
82,760 bases
Orientation:
Plus strand

Genomic View for WDR37 Gene

Genes around WDR37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR37 Gene

Proteins for WDR37 Gene

  • Protein details for WDR37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2I8-WDR37_HUMAN
    Recommended name:
    WD repeat-containing protein 37
    Protein Accession:
    Q9Y2I8
    Secondary Accessions:
    • A8K976
    • D3DRQ7
    • Q5SW03
    • Q8WVG2
    • Q9NTJ6

    Protein attributes for WDR37 Gene

    Size:
    494 amino acids
    Molecular mass:
    54665 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76826.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR37 Gene

Post-translational modifications for WDR37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR37 Gene

No data available for DME Specific Peptides for WDR37 Gene

Domains & Families for WDR37 Gene

Gene Families for WDR37 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR37 Gene

GenScript: Design optimal peptide antigens:
  • WDR37 protein (Q8WVG2_HUMAN)
  • WD repeat-containing protein 37 (WDR37_HUMAN)
genes like me logo Genes that share domains with WDR37: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR37 Gene

Function for WDR37 Gene

Phenotypes From GWAS Catalog for WDR37 Gene

genes like me logo Genes that share phenotypes with WDR37: view

Animal Models for WDR37 Gene

MGI Knock Outs for WDR37:
  • Wdr37 Wdr37<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR37

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR37 Gene

Localization for WDR37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR37 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 2
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030687 preribosome, large subunit precursor IBA 21873635
GO:0070545 PeBoW complex IBA 21873635
genes like me logo Genes that share ontologies with WDR37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR37 Gene

Pathways & Interactions for WDR37 Gene

PathCards logo

SuperPathways for WDR37 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR37 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR37 Gene

Drugs & Compounds for WDR37 Gene

No Compound Related Data Available

Transcripts for WDR37 Gene

mRNA/cDNA for WDR37 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR37

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR37 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10: -
SP11:
SP12:

ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for WDR37 Gene

GeneLoc Exon Structure for
WDR37

Expression for WDR37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR37 Gene

Protein differential expression in normal tissues from HIPED for WDR37 Gene

This gene is overexpressed in Cervix (20.8), Peripheral blood mononuclear cells (9.4), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR37 Gene



Protein tissue co-expression partners for WDR37 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR37

SOURCE GeneReport for Unigene cluster for WDR37 Gene:

Hs.188495

Evidence on tissue expression from TISSUES for WDR37 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with WDR37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR37 Gene

Orthologs for WDR37 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR37 31 30
  • 99.8 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR37 31
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR37 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR37 31 30
  • 87.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr37 17 31 30
  • 87.92 (n)
rat
(Rattus norvegicus)
Mammalia Wdr37 30
  • 87.84 (n)
cow
(Bos Taurus)
Mammalia WDR37 31 30
  • 86.3 (n)
OneToOne
chicken
(Gallus gallus)
Aves WDR37 31 30
  • 79.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR37 31
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr37 30
  • 76.79 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr37 31 30
  • 74.63 (n)
OneToOne
Dr.7221 30
fruit fly
(Drosophila melanogaster)
Insecta CG12333 31 30
  • 57.68 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004374 30
  • 55.18 (n)
worm
(Caenorhabditis elegans)
Secernentea C05D2.10 31 30
  • 51.71 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTM1 31
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
OneToOne
Species where no ortholog for WDR37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR37 Gene

ENSEMBL:
Gene Tree for WDR37 (if available)
TreeFam:
Gene Tree for WDR37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR37: view image

Paralogs for WDR37 Gene

Paralogs for WDR37 Gene

(1) SIMAP similar genes for WDR37 Gene using alignment to 4 proteins:

  • WDR37_HUMAN
  • C9JGR9_HUMAN
  • E7EQ49_HUMAN
  • Q8WVG2_HUMAN
genes like me logo Genes that share paralogs with WDR37: view

Variants for WDR37 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR37 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
633616 Likely Pathogenic: Congenital ocular coloboma; Intellectual disability; Congenital cerebellar hypoplasia; Epilepsy; Developmental delay; Dysmorphism; NEUROOCULOCARDIOGENITOURINARY SYNDROME 1,080,466(+) C/G MISSENSE_VARIANT
633617 Likely Pathogenic: Congenital ocular coloboma; Intellectual disability; Congenital cerebellar hypoplasia; Epilepsy; Developmental delay; Dysmorphism; NEUROOCULOCARDIOGENITOURINARY SYNDROME 1,080,436(+) C/T MISSENSE_VARIANT
633618 Likely Pathogenic: Congenital ocular coloboma; Intellectual disability; Congenital cerebellar hypoplasia; Epilepsy; Developmental delay; Dysmorphism; NEUROOCULOCARDIOGENITOURINARY SYNDROME 1,080,469(+) C/T MISSENSE_VARIANT
rs1554823375 Likely Pathogenic: Congenital ocular coloboma; Intellectual disability; Cerebellar vermis hypoplasia; Congenital cerebellar hypoplasia; Ventriculomegaly; Epilepsy; Developmental delay; Dysmorphism; NEUROOCULOCARDIOGENITOURINARY SYNDROME; not provided 1,080,454(+) C/T MISSENSE_VARIANT
rs17856556 - p.Gln221Lys

Additional dbSNP identifiers (rs#s) for WDR37 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR37 Gene

Variant ID Type Subtype PubMed ID
esv1009406 CNV deletion 20482838
esv1356116 CNV deletion 17803354
esv2573324 CNV deletion 19546169
esv2660097 CNV deletion 23128226
esv2662183 CNV deletion 23128226
esv2729406 CNV deletion 23290073
esv2729417 CNV deletion 23290073
esv2729428 CNV deletion 23290073
esv2729439 CNV deletion 23290073
esv3622096 CNV gain 21293372
esv3891735 CNV gain 25118596
nsv1041498 CNV gain 25217958
nsv1046220 CNV gain 25217958
nsv1054432 CNV gain 25217958
nsv1161922 CNV duplication 26073780
nsv476445 CNV novel sequence insertion 20440878
nsv521885 CNV loss 19592680
nsv549765 CNV gain 21841781
nsv549768 CNV gain 21841781
nsv951232 CNV duplication 24416366

Variation tolerance for WDR37 Gene

Residual Variation Intolerance Score: 4.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR37

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR37 Gene

Disorders for WDR37 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WDR37 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
neurooculocardiogenitourinary syndrome
  • nocgus
coloboma of macula
  • agenesis of macula
- elite association - COSMIC cancer census association via MalaCards
Search WDR37 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR37

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WDR37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR37 Gene

Publications for WDR37 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 54
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 41 54
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 41 54

Products for WDR37 Gene

Sources for WDR37 Gene