Aliases for WDR33 Gene
External Ids for WDR33 Gene
Previous GeneCards Identifiers for WDR33 Gene
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for WDR33 Gene
WDR33 (WD Repeat Domain 33) is a Protein Coding gene. Diseases associated with WDR33 include Atrial Septal Defect 6. Among its related pathways are Processing of Capped Intronless Pre-mRNA and Tat-mediated elongation of the HIV-1 transcript.
UniProtKB/Swiss-Prot Summary for WDR33 Gene
Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.