This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal tran... See more...

Aliases for WDR26 Gene

Aliases for WDR26 Gene

  • WD Repeat Domain 26 2 3 5
  • CUL4- And DDB1-Associated WDR Protein 2 3 4
  • WD Repeat-Containing Protein 26 3 4
  • CDW2 3 4
  • GID7 2 3
  • MIP2 3 4
  • Myocardial Ischemic Preconditioning Up-Regulated Protein 2 4
  • Myocardial Ischemic Preconditioning Upregulated Protein 2 3
  • GID Complex Subunit 7 Homolog (S. Cerevisiae) 2
  • GID Complex Subunit 7 Homolog 3
  • EC 1.4.4.2 51
  • EC 2.7.7.8 51
  • FLJ21016 2
  • SKDEAS 3
  • WDR26 5

External Ids for WDR26 Gene

Previous GeneCards Identifiers for WDR26 Gene

  • GC01M220982
  • GC01M221550
  • GC01M221549
  • GC01M220881
  • GC01M222641
  • GC01M224573
  • GC01M195092

Summaries for WDR26 Gene

Entrez Gene Summary for WDR26 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR26 Gene

WDR26 (WD Repeat Domain 26) is a Protein Coding gene. Diseases associated with WDR26 include Skraban-Deardorff Syndrome and Disease Of Mental Health. An important paralog of this gene is WDR13.

UniProtKB/Swiss-Prot Summary for WDR26 Gene

  • G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).

Gene Wiki entry for WDR26 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR26 Gene

Genomics for WDR26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WDR26 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR26

Top Transcription factor binding sites by QIAGEN in the WDR26 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • Elk-1
  • NF-Y
  • NF-YA
  • NF-YB
  • Olf-1
  • Pax-5

Genomic Locations for WDR26 Gene

Latest Assembly
chr1:224,385,146-224,437,033
(GRCh38/hg38)
Size:
51,888 bases
Orientation:
Minus strand

Previous Assembly
chr1:224,572,848-224,622,499
(GRCh37/hg19 by Entrez Gene)
Size:
49,652 bases
Orientation:
Minus strand

chr1:224,572,845-224,624,735
(GRCh37/hg19 by Ensembl)
Size:
51,891 bases
Orientation:
Minus strand

Genomic View for WDR26 Gene

Genes around WDR26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR26 Gene

Proteins for WDR26 Gene

  • Protein details for WDR26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7D7-WDR26_HUMAN
    Recommended name:
    WD repeat-containing protein 26
    Protein Accession:
    Q9H7D7
    Secondary Accessions:
    • A0MNN3
    • Q4G100
    • Q59EC4
    • Q5GLZ9
    • Q86UY4
    • Q9H3C2

    Protein attributes for WDR26 Gene

    Size:
    661 amino acids
    Molecular mass:
    72124 Da
    Quaternary structure:
    • Forms homooligomers (PubMed:23625927). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972). Interacts with DDB1-CUL4A/B E3 ligase complexes (PubMed:17041588). Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2 (PubMed:22065575, PubMed:23625927). Interacts with AXIN1 (PubMed:27098453).
    SequenceCaution:
    • Sequence=AAG35477.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH52301.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH63817.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAO67709.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAQ74770.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABK41102.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14955.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAD93124.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR26 Gene

Selected DME Specific Peptides for WDR26 Gene

Q9H7D7:
  • DLRAKAE
  • DDGTVRI

Post-translational modifications for WDR26 Gene

  • Ubiquitination at Lys212 and Lys536
  • Modification sites at PhosphoSitePlus

Domains & Families for WDR26 Gene

Gene Families for WDR26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for WDR26 Gene

InterPro:
Blocks:
  • CTLH, C-terminal to LisH motif
ProtoNet:

Suggested Antigen Peptide Sequences for WDR26 Gene

GenScript: Design optimal peptide antigens:
  • Myocardial ischemic preconditioning up-regulated protein 2 (WDR26_HUMAN)
genes like me logo Genes that share domains with WDR26: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR26 Gene

Function for WDR26 Gene

Molecular function for WDR26 Gene

UniProtKB/Swiss-Prot Function:
G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
UniProtKB/Swiss-Prot Induction:
Expression is significantly up-regulated by oxidative stress (PubMed:19446606).

Enzyme Numbers (IUBMB) for WDR26 Gene

Phenotypes From GWAS Catalog for WDR26 Gene

Gene Ontology (GO) - Molecular Function for WDR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17510365
genes like me logo Genes that share ontologies with WDR26: view
genes like me logo Genes that share phenotypes with WDR26: view

Human Phenotype Ontology for WDR26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for WDR26 Gene

miRTarBase miRNAs that target WDR26

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR26

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for WDR26 Gene

Localization for WDR26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR26 Gene

Cytoplasm. Nucleus. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR26 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
plasma membrane 1
extracellular 1
cytoskeleton 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 29911972
GO:0005634 nucleus IEA,IDA 29911972
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 15378603
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with WDR26: view

Pathways & Interactions for WDR26 Gene

PathCards logo

SuperPathways for WDR26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR26 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR26 Gene

Drugs & Compounds for WDR26 Gene

No Compound Related Data Available

Transcripts for WDR26 Gene

mRNA/cDNA for WDR26 Gene

3 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR26

Alternative Splicing Database (ASD) splice patterns (SP) for WDR26 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for WDR26 Gene

GeneLoc Exon Structure for
WDR26

Expression for WDR26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR26 Gene

This gene is overexpressed in Cervix (25.7) and Peripheral blood mononuclear cells (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR26 Gene



Protein tissue co-expression partners for WDR26 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR26

SOURCE GeneReport for Unigene cluster for WDR26 Gene:

Hs.497873

mRNA Expression by UniProt/SwissProt for WDR26 Gene:

Q9H7D7-WDR26_HUMAN
Tissue specificity: Broadly expressed, with highest levels in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for WDR26 Gene

  • Heart(4.4)
  • Lung(4.4)
  • Liver(4.4)
  • Nervous system(4.1)
  • Kidney(2.4)
  • Blood(2.1)
  • Muscle(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with WDR26: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR26 Gene

Orthologs for WDR26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR26 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WDR26 30 31
  • 100 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WDR26 30 31
  • 97.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WDR26 30 31
  • 95.2 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wdr26 30
  • 92.93 (n)
Mouse
(Mus musculus)
Mammalia Wdr26 30 17 31
  • 92.56 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WDR26 31
  • 87 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WDR26 31
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WDR26 30 31
  • 87.1 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WDR26 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wdr26 30
  • 81.91 (n)
Str.17077 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6906 30
Zebrafish
(Danio rerio)
Actinopterygii CABZ01044136.1 31
  • 82 (a)
OneToMany
wdr26b 30 31
  • 74.17 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006042 30
  • 59.22 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7611 30 31
  • 57.21 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y39H10A.6 30 31
  • 41.82 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GID7 31
  • 18 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G43920 30
  • 49.86 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2798 31
  • 56 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU04101 30
  • 47.87 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC343.04c 30
  • 45.28 (n)
Species where no ortholog for WDR26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WDR26 Gene

ENSEMBL:
Gene Tree for WDR26 (if available)
TreeFam:
Gene Tree for WDR26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR26: view image

Paralogs for WDR26 Gene

Paralogs for WDR26 Gene

(2) SIMAP similar genes for WDR26 Gene using alignment to 5 proteins:

  • WDR26_HUMAN
  • C9JCS7_HUMAN
  • H0Y917_HUMAN
  • H0Y9R3_HUMAN
  • L8EAE8_HUMAN
genes like me logo Genes that share paralogs with WDR26: view

Variants for WDR26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR26 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
928665 Uncertain Significance: not specified 224,418,383(-) C/T
NM_025160.7(WDR26):c.896G>A (p.Arg299Gln)
MISSENSE
930867 Pathogenic: Skraban-Deardorff syndrome 224,411,426(-) C/T
NM_001379403.1(WDR26):c.1458+1G>A
SPLICE_DONOR
931463 Uncertain Significance: Skraban-Deardorff syndrome 224,418,262(-) A/C
NM_001379403.1(WDR26):c.1317T>G (p.Ser439Arg)
MISSENSE
962945 Uncertain Significance: not provided 224,431,591(-) T/C
NM_001379403.1(WDR26):c.823-10A>G
INTRON
981417 Pathogenic: Intellectual disability 224,398,514(-) C/G
NM_001379403.1(WDR26):c.1944+1G>C
SPLICE_DONOR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for WDR26 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for WDR26 Gene

Variant ID Type Subtype PubMed ID
dgv149e212 CNV loss 25503493
nsv160255 CNV deletion 16902084
nsv469889 CNV gain 16826518
nsv475735 CNV novel sequence insertion 20440878
nsv508062 OTHER sequence alteration 20534489
nsv8868 CNV loss 18304495

Variation tolerance for WDR26 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR26 Gene

Human Gene Mutation Database (HGMD)
WDR26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR26

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR26 Gene

Disorders for WDR26 Gene

MalaCards: The human disease database

(8) MalaCards diseases for WDR26 Gene - From: OMI, CVR, GTR, ORP, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search WDR26 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WDR26_HUMAN
  • Skraban-Deardorff syndrome (SKDEAS) [MIM:617616]: An autosomal dominant syndrome characterized by psychomotor developmental delay, intellectual disability with delayed speech, febrile and non-febrile seizures, abnormal gait, and facial dysmorphism. Facial features include a prominent maxilla and upper lip that readily reveal the upper gingiva, widely spaced teeth, and a broad nasal tip. {ECO:0000269 PubMed:28686853}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for WDR26

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with WDR26: view

No data available for Genatlas for WDR26 Gene

Publications for WDR26 Gene

  1. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. (PMID: 29911972) Lampert F … Peter M (eLife 2018) 3 4
  2. WDR26 Haploinsufficiency Causes a Recognizable Syndrome of Intellectual Disability, Seizures, Abnormal Gait, and Distinctive Facial Features. (PMID: 28686853) Skraban CM … Deardorff MA (American journal of human genetics 2017) 3 4
  3. WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway. (PMID: 27098453) Goto T … Shibuya H (FEBS letters 2016) 3 4
  4. Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion. (PMID: 26895380) Ye Y … Chen S (Oncotarget 2016) 3 4
  5. WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes. (PMID: 23625927) Sun Z … Chen S (The Journal of biological chemistry 2013) 3 4

Products for WDR26 Gene

Sources for WDR26 Gene