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This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal tran... See more...
Aliases for WDR26 Gene
Aliases for WDR26 Gene
External Ids for WDR26 Gene
- HGNC: 21208
- NCBI Entrez Gene: 80232
- Ensembl: ENSG00000162923
- OMIM®: 617424
- UniProtKB/Swiss-Prot: Q9H7D7
Previous GeneCards Identifiers for WDR26 Gene
- GC01M220982
- GC01M221550
- GC01M221549
- GC01M220881
- GC01M222641
- GC01M224573
- GC01M195092
Summaries for WDR26 Gene
-
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for WDR26 Gene
WDR26 (WD Repeat Domain 26) is a Protein Coding gene. Diseases associated with WDR26 include Skraban-Deardorff Syndrome and Disease Of Mental Health. An important paralog of this gene is WDR13.
UniProtKB/Swiss-Prot Summary for WDR26 Gene
-
G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
Additional gene information for WDR26 Gene
- HGNC (21208)
- NCBI Entrez Gene (80232)
- Ensembl (ENSG00000162923)
- OMIM® (617424)
- UniProtKB/Swiss-Prot (Q9H7D7)
- Open Targets Platform(ENSG00000162923)
- Search for WDR26 at DataMed
- Search for WDR26 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR26 Gene
Genomics for WDR26 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for WDR26 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around WDR26 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR26
- Top Transcription factor binding sites by QIAGEN in the WDR26 gene promoter:
-
- CBF(2)
- CBF-A
- CBF-B
- CP1A
- Elk-1
- NF-Y
- NF-YA
- NF-YB
- Olf-1
- Pax-5
Genomic Locations for WDR26 Gene
Latest Assembly
- chr1:224,385,146-224,437,033
- (GRCh38/hg38)
- Size:
- 51,888 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:224,572,848-224,622,499
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 49,652 bases
- Orientation:
- Minus strand
- chr1:224,572,845-224,624,735
- (GRCh37/hg19 by Ensembl)
- Size:
- 51,891 bases
- Orientation:
- Minus strand
Genomic View for WDR26 Gene
Genes around WDR26 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q42.11-q42.12 by HGNC
- 1q42.11-q42.12 by Entrez Gene
- 1q42.12 by Ensembl
WDR26 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WDR26 Gene
Proteins for WDR26 Gene
-
Protein details for WDR26 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H7D7-WDR26_HUMAN
- Recommended name:
- WD repeat-containing protein 26
- Protein Accession:
- Q9H7D7
- A0MNN3
- Q4G100
- Q59EC4
- Q5GLZ9
- Q86UY4
- Q9H3C2
Protein attributes for WDR26 Gene
- Size:
- 661 amino acids
- Molecular mass:
- 72124 Da
- Quaternary structure:
-
- Forms homooligomers (PubMed:23625927). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972). Interacts with DDB1-CUL4A/B E3 ligase complexes (PubMed:17041588). Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2 (PubMed:22065575, PubMed:23625927). Interacts with AXIN1 (PubMed:27098453).
- SequenceCaution:
-
- Sequence=AAG35477.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH52301.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH63817.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAO67709.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAQ74770.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABK41102.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14955.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAD93124.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for WDR26 Gene
Selected DME Specific Peptides for WDR26 Gene
- Q9H7D7:
-
- DLRAKAE
- DDGTVRI
Post-translational modifications for WDR26 Gene
Other Protein References for WDR26 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for WDR26
- Novus Biologicals Antibodies for WDR26
-
Abcam antibodies for WDR26
- Invitrogen Antibodies for WDR26 (AFLGC-WDR26)
-
Biorbyt antibodies for WDR26
-
Custom Antibody ServicesProSci Antibodies for WDR26
Protein products for research
-
OriGene Purified Proteins for WDR26
- Search Origene for MassSpec and Protein Over-expression Lysates for WDR26
- Origene Custom Protein Services for WDR26
- Novus Biologicals proteins for WDR26
- antibodies-online: Show 2 available WDR26 Proteins ranked by validation data
- Compare Top WDR26 Proteins
-
Quality Products:
Assay products for research
Domains & Families for WDR26 Gene
Gene Families for WDR26 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for WDR26 Gene
- InterPro:
- Blocks:
-
- CTLH, C-terminal to LisH motif
- ProtoNet:
Suggested Antigen Peptide Sequences for WDR26 Gene
- GenScript: Design optimal peptide antigens:
-
- Myocardial ischemic preconditioning up-regulated protein 2 (WDR26_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR26 Gene
Function for WDR26 Gene
Molecular function for WDR26 Gene
- UniProtKB/Swiss-Prot Function:
- G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Expression is significantly up-regulated by oxidative stress (PubMed:19446606).
Enzyme Numbers (IUBMB) for WDR26 Gene
Phenotypes From GWAS Catalog for WDR26 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 17510365 |
Phenotypes for WDR26 Gene
- GenomeRNAi human phenotypes for WDR26:
-
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- Decreased viability
- no effect
- FOXO1 nuclear localization
- Decreased homologous recombination repair frequency
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Polylobed nuclei, dynamic nuclei (hole, folded or small irregular)
- Increased G1 length
- Increased S length
- Increased G1 length, increased S length
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for WDR26 - Starting at $85 >
- * WDR26 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for WDR26
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WDR26
-
Santa Cruz Biotechnology (SCBT) CRISPR for WDR26
miRNA for WDR26 Gene
- miRTarBase miRNAs that target WDR26
-
- hsa-miR-140-3p (MIRT021671)
- hsa-miR-93-5p (MIRT028144)
- hsa-miR-19b-3p (MIRT031263)
- hsa-miR-484 (MIRT041889)
- hsa-miR-30e-5p (MIRT044145)
- hsa-miR-92a-3p (MIRT049756)
- hsa-let-7b-5p (MIRT052146)
- hsa-miR-3200-5p (MIRT063696)
- hsa-miR-19a-3p (MIRT063711)
- hsa-miR-5003-3p (MIRT185388)
- hsa-miR-183-5p (MIRT271532)
- hsa-miR-548n (MIRT271547)
- hsa-miR-29a-3p (MIRT437727)
- hsa-miR-29b-3p (MIRT437728)
- hsa-miR-29c-3p (MIRT437729)
- hsa-miR-4452 (MIRT444803)
- hsa-miR-183-3p (MIRT444804)
- hsa-miR-4635 (MIRT444806)
- hsa-miR-4282 (MIRT449342)
- hsa-miR-222-5p (MIRT464007)
- hsa-miR-6086 (MIRT464008)
- hsa-miR-377-5p (MIRT464009)
- hsa-miR-655-5p (MIRT464010)
- hsa-miR-4766-5p (MIRT464011)
- hsa-miR-16-1-3p (MIRT464012)
- hsa-miR-3065-3p (MIRT464013)
- hsa-miR-5092 (MIRT464014)
- hsa-miR-1263 (MIRT546003)
- hsa-miR-150-3p (MIRT546004)
- hsa-miR-548aw (MIRT546005)
- hsa-miR-7641 (MIRT546006)
- hsa-miR-1468-3p (MIRT546007)
- hsa-miR-548x-5p (MIRT546008)
- hsa-miR-548g-5p (MIRT546009)
- hsa-miR-548f-5p (MIRT546010)
- hsa-miR-548aj-5p (MIRT546011)
- hsa-miR-455-5p (MIRT546012)
- hsa-miR-4672 (MIRT546013)
- hsa-miR-466 (MIRT546014)
- hsa-miR-3941 (MIRT546015)
- hsa-miR-4790-3p (MIRT546016)
- hsa-miR-6747-3p (MIRT546017)
- hsa-miR-6727-3p (MIRT546018)
- hsa-miR-4722-3p (MIRT546019)
- hsa-miR-6768-5p (MIRT546020)
- hsa-miR-5197-3p (MIRT546021)
- hsa-miR-548l (MIRT552874)
- hsa-miR-595 (MIRT561366)
- hsa-miR-4659b-5p (MIRT571565)
- hsa-miR-4495 (MIRT571566)
- hsa-miR-4659a-5p (MIRT571567)
- hsa-miR-708-3p (MIRT571568)
- mmu-miR-873a-5p (MIRT577099)
- mmu-miR-466o-3p (MIRT588484)
- mmu-miR-466m-3p (MIRT588485)
- mmu-miR-3084-3p (MIRT588486)
- mmu-miR-760-5p (MIRT592959)
- mmu-miR-290a-5p (MIRT593129)
- mmu-miR-292a-5p (MIRT593130)
- mmu-miR-5097 (MIRT594061)
- mmu-miR-433-3p (MIRT594062)
- mmu-miR-3088-3p (MIRT594063)
- mmu-miR-878-3p (MIRT594064)
- mmu-miR-714 (MIRT594065)
- mmu-miR-335-3p (MIRT594066)
- hsa-miR-514b-3p (MIRT651575)
- hsa-miR-514a-3p (MIRT651576)
- hsa-miR-6809-3p (MIRT651577)
- hsa-miR-4752 (MIRT651578)
- hsa-miR-6833-5p (MIRT651579)
- hsa-miR-489-3p (MIRT651580)
- hsa-miR-6844 (MIRT651581)
- hsa-miR-4753-3p (MIRT651582)
- hsa-miR-8056 (MIRT651583)
- hsa-miR-3691-5p (MIRT651584)
- hsa-miR-376c-5p (MIRT651585)
- hsa-miR-376b-5p (MIRT651586)
- hsa-miR-3913-3p (MIRT651587)
- hsa-miR-130b-5p (MIRT651588)
- hsa-miR-877-3p (MIRT651589)
- hsa-miR-4687-5p (MIRT651590)
- mmu-miR-466f-3p (MIRT791468)
- mmu-miR-466q (MIRT791612)
- mmu-miR-467f (MIRT791751)
- mmu-miR-669c-3p (MIRT791920)
- mmu-miR-7212-3p (MIRT792058)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WDR26
- Browse OriGene Inhibitory RNA Products For WDR26
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR26
Clone products for research
- Applied Biological Materials (abm): Clones for WDR26 - Starting at $45 >
- * WDR26 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for WDR26
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WDR26
Cell Lines for research
-
Horizon Cell Lines for WDR26
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for WDR26 Gene
Localization for WDR26 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WDR26 Gene
- Cytoplasm. Nucleus. Mitochondrion.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (4)
- Nucleoplasm (4)
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IDA | 29911972 |
| GO:0005634 | nucleus | IEA,IDA | 29911972 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 15378603 |
| GO:0005739 | mitochondrion | IDA | -- |
Pathways & Interactions for WDR26 Gene
Interacting Proteins for WDR26 Gene
Selected Interacting proteins:
Q9H7D7-WDR26_HUMAN
ENSP00000408108
for WDR26 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for WDR26
No data available for Pathways by source and SIGNOR curated interactions for WDR26 Gene
Transcripts for WDR26 Gene
mRNA/cDNA for WDR26 Gene
- 3 REFSEQ mRNAs :
- 23 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000414423 7367 nts (view in UCSC)
- ENST00000443112 1306 nts (view in UCSC)
- ENST00000445239 784 nts (view in UCSC)
- ENST00000477425 529 nts (view in UCSC)
- ENST00000479727 795 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for WDR26 - Starting at $85 >
- * WDR26 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for WDR26
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WDR26
-
Santa Cruz Biotechnology (SCBT) CRISPR for WDR26
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WDR26
- Browse OriGene Inhibitory RNA Products For WDR26
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR26
Clone products for research
- Applied Biological Materials (abm): Clones for WDR26 - Starting at $45 >
- * WDR26 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for WDR26
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WDR26
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for WDR26 Gene
- GeneLoc Exon Structure for
- WDR26
Expression for WDR26 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
- Bone (Muscoskeletal System)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Cervix (25.7) and Peripheral blood mononuclear cells (14.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR26 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR26
SOURCE GeneReport for Unigene cluster for WDR26 Gene:
Hs.497873mRNA Expression by UniProt/SwissProt for WDR26 Gene:
Q9H7D7-WDR26_HUMAN
Tissue specificity:
Broadly expressed, with highest levels in heart and skeletal muscle.
Evidence on tissue expression from TISSUES for WDR26 Gene
- Heart(4.4)
- Lung(4.4)
- Liver(4.4)
- Nervous system(4.1)
- Kidney(2.4)
- Blood(2.1)
- Muscle(2.1)
- Skin(2)
Primer products for research
-
OriGene qPCR primer pairs for WDR26
-
OriGene qPCR primer pairs and template standards for WDR26
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR26 Gene
Orthologs for WDR26 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | WDR26 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | WDR26 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | WDR26 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Wdr26 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Wdr26 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | WDR26 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | WDR26 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | WDR26 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | WDR26 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wdr26 30 |
|
||
| Str.17077 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6906 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CABZ01044136.1 31 |
|
OneToMany | |
| wdr26b 30 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006042 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG7611 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | Y39H10A.6 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GID7 31 |
|
OneToOne | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G43920 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2798 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU04101 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC343.04c 30 |
|
- Species where no ortholog for WDR26 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for WDR26 Gene
- ENSEMBL:
- Gene Tree for WDR26 (if available)
- TreeFam:
- Gene Tree for WDR26 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WDR26: view image
Paralogs for WDR26 Gene
Variants for WDR26 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR26 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 928665 | Uncertain Significance: not specified | 224,418,383(-) |
C/T NM_025160.7(WDR26):c.896G>A (p.Arg299Gln) |
MISSENSE | |
| 930867 | Pathogenic: Skraban-Deardorff syndrome | 224,411,426(-) |
C/T NM_001379403.1(WDR26):c.1458+1G>A |
SPLICE_DONOR | |
| 931463 | Uncertain Significance: Skraban-Deardorff syndrome | 224,418,262(-) |
A/C NM_001379403.1(WDR26):c.1317T>G (p.Ser439Arg) |
MISSENSE | |
| 962945 | Uncertain Significance: not provided | 224,431,591(-) |
T/C NM_001379403.1(WDR26):c.823-10A>G |
INTRON | |
| 981417 | Pathogenic: Intellectual disability | 224,398,514(-) |
C/G NM_001379403.1(WDR26):c.1944+1G>C |
SPLICE_DONOR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.41;
9.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WDR26 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR26 Gene
Disorders for WDR26 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| skraban-deardorff syndrome |
|
|
| disease of mental health |
|
|
| alacrima, achalasia, and mental retardation syndrome |
|
|
| wdr26-related intellectual disability |
|
|
| chromosome 1q41-q42 deletion syndrome |
|
|
Search WDR26 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
WDR26_HUMAN- Skraban-Deardorff syndrome (SKDEAS) [MIM:617616]: An autosomal dominant syndrome characterized by psychomotor developmental delay, intellectual disability with delayed speech, febrile and non-febrile seizures, abnormal gait, and facial dysmorphism. Facial features include a prominent maxilla and upper lip that readily reveal the upper gingiva, widely spaced teeth, and a broad nasal tip. {ECO:0000269 PubMed:28686853}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for WDR26
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for WDR26 Gene
Publications for WDR26 Gene
- The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. (PMID: 29911972) Lampert F … Peter M (eLife 2018) 3 4
- WDR26 Haploinsufficiency Causes a Recognizable Syndrome of Intellectual Disability, Seizures, Abnormal Gait, and Distinctive Facial Features. (PMID: 28686853) Skraban CM … Deardorff MA (American journal of human genetics 2017) 3 4
- WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway. (PMID: 27098453) Goto T … Shibuya H (FEBS letters 2016) 3 4
- Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion. (PMID: 26895380) Ye Y … Chen S (Oncotarget 2016) 3 4
- WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes. (PMID: 23625927) Sun Z … Chen S (The Journal of biological chemistry 2013) 3 4
ExternalLinks
Products for WDR26 Gene
- Custom Antibody ServicesOriGene Antibodies for WDR26
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- antibodies-online: Show 6 available WDR26 Antibodies ranked by validation data
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- antibodies-online: Show 2 available WDR26 Proteins ranked by validation data
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- Horizon Cell Lines for WDR26
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WDR26
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR26
- Biorbyt antibodies for WDR26
Sources for WDR26 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
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- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
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- (174) Open Targets Platform
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- (176) snoDB
- (177) MirGeneDB