Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR26 Gene

Aliases for WDR26 Gene

  • WD Repeat Domain 26 2 3 5
  • CUL4- And DDB1-Associated WDR Protein 2 3 4
  • MIP2 3 4
  • CDW2 3 4
  • Myocardial Ischemic Preconditioning Up-Regulated Protein 2 4
  • Myocardial Ischemic Preconditioning Upregulated Protein 2 3
  • GID Complex Subunit 7 Homolog (S. Cerevisiae) 2
  • WD Repeat-Containing Protein 26 3
  • GID Complex Subunit 7 Homolog 3
  • EC 1.4.4.2 56
  • EC 2.7.7.8 56
  • SKDEAS 3
  • GID7 3

External Ids for WDR26 Gene

Previous GeneCards Identifiers for WDR26 Gene

  • GC01M220982
  • GC01M221550
  • GC01M221549
  • GC01M220881
  • GC01M222641
  • GC01M224573
  • GC01M195092

Summaries for WDR26 Gene

Entrez Gene Summary for WDR26 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR26 Gene

WDR26 (WD Repeat Domain 26) is a Protein Coding gene. Diseases associated with WDR26 include Skraban-Deardorff Syndrome and Klebsiella Infection.

UniProtKB/Swiss-Prot for WDR26 Gene

  • G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).

Gene Wiki entry for WDR26 Gene

Additional gene information for WDR26 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR26 Gene

Genomics for WDR26 Gene

GeneHancer (GH) Regulatory Elements for WDR26 Gene

Promoters and enhancers for WDR26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I224429 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +3.5 3525 7.2 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 MEF2D ZNF610 CNIH3 WDR26 CNIH4 NVL CICP5 GTF2IP20 GC01P224430
GH01I223710 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.5 +720.7 720709 11.8 ZFP64 FEZF1 YY1 ZNF213 ZNF143 ZNF548 SP3 ZFP41 MEF2D ZNF610 CAPN2 CICP5 NVL LOC100287497 TP53BP2 WDR26 CAPN8 GTF2IP20 FBXO28 RNU6-1248P
GH01I224501 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 31.4 -66.3 -66320 3 FEZF1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 MEF2D NVL CICP5 LOC100287497 WDR26 CNIH4 GTF2IP20 CNIH3 CAPN2 LOC105373110 GC01P224480
GH01I223704 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 32.6 +730.0 729980 5.5 HDGF PKNOX1 FOXA2 ARNT NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC105373281 CICP5 CAPN2 WDR26 LOC100287497 NVL CNIH4 CAPN8 FBXO28 AIDA
GH01I223844 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21 +591.3 591280 3.4 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 TP53BP2 GC01P223846 GC01P223847 CICP5 NVL LOC100287497 CAPN2 FBXO28 WDR26 CNIH4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR26 gene promoter:

Genomic Locations for WDR26 Gene

Genomic Locations for WDR26 Gene
chr1:224,385,143-224,437,033
(GRCh38/hg38)
Size:
51,891 bases
Orientation:
Minus strand
chr1:224,572,845-224,624,735
(GRCh37/hg19)

Genomic View for WDR26 Gene

Genes around WDR26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR26 Gene

Proteins for WDR26 Gene

  • Protein details for WDR26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7D7-WDR26_HUMAN
    Recommended name:
    WD repeat-containing protein 26
    Protein Accession:
    Q9H7D7
    Secondary Accessions:
    • A0MNN3
    • Q4G100
    • Q59EC4
    • Q5GLZ9
    • Q86UY4
    • Q9H3C2

    Protein attributes for WDR26 Gene

    Size:
    661 amino acids
    Molecular mass:
    72124 Da
    Quaternary structure:
    • Forms homooligomers (PubMed:23625927). Interacts with DDB1-CUL4A/B E3 ligase complexes (PubMed:17041588). Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2 (PubMed:22065575, PubMed:23625927). Interacts with AXIN1 (PubMed:27098453).
    SequenceCaution:
    • Sequence=AAG35477.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH52301.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH63817.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO67709.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ74770.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABK41102.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14955.1; Type=Erroneous termination; Positions=274; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=BAD93124.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR26 Gene

Selected DME Specific Peptides for WDR26 Gene

Q9H7D7:
  • DLRAKAE
  • DDGTVRI

Post-translational modifications for WDR26 Gene

  • Ubiquitination at isoforms=2212 and isoforms=2536

Domains & Families for WDR26 Gene

Gene Families for WDR26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR26 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR26: view

No data available for UniProtKB/Swiss-Prot for WDR26 Gene

Function for WDR26 Gene

Molecular function for WDR26 Gene

UniProtKB/Swiss-Prot Function:
G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
UniProtKB/Swiss-Prot Induction:
Expression is significantly up-regulated by oxidative stress (PubMed:19446606).

Enzyme Numbers (IUBMB) for WDR26 Gene

Phenotypes From GWAS Catalog for WDR26 Gene

Gene Ontology (GO) - Molecular Function for WDR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17510365
genes like me logo Genes that share ontologies with WDR26: view
genes like me logo Genes that share phenotypes with WDR26: view

miRNA for WDR26 Gene

miRTarBase miRNAs that target WDR26

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR26 Gene

Localization for WDR26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR26 Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR26 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 15378603
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with WDR26: view

Pathways & Interactions for WDR26 Gene

SuperPathways for WDR26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR26 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR26 Gene

Drugs & Compounds for WDR26 Gene

No Compound Related Data Available

Transcripts for WDR26 Gene

Unigene Clusters for WDR26 Gene

WD repeat domain 26:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR26 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for WDR26 Gene

GeneLoc Exon Structure for
WDR26
ECgene alternative splicing isoforms for
WDR26

Expression for WDR26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR26 Gene

This gene is overexpressed in Cervix (25.7) and Peripheral blood mononuclear cells (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR26 Gene



Protein tissue co-expression partners for WDR26 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR26 Gene:

WDR26

SOURCE GeneReport for Unigene cluster for WDR26 Gene:

Hs.497873

mRNA Expression by UniProt/SwissProt for WDR26 Gene:

Q9H7D7-WDR26_HUMAN
Tissue specificity: Broadly expressed, with highest levels in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for WDR26 Gene

  • Heart(4.4)
  • Lung(4.4)
  • Liver(4.3)
  • Nervous system(3.9)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with WDR26: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR26 Gene

Orthologs for WDR26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR26 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia WDR26 33 34
  • 97.08 (n)
dog
(Canis familiaris)
Mammalia WDR26 33 34
  • 95.2 (n)
rat
(Rattus norvegicus)
Mammalia Wdr26 33
  • 92.93 (n)
mouse
(Mus musculus)
Mammalia Wdr26 33 16 34
  • 92.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR26 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR26 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR26 33 34
  • 87.1 (n)
lizard
(Anolis carolinensis)
Reptilia WDR26 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr26 33
  • 81.91 (n)
Str.17077 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6906 33
zebrafish
(Danio rerio)
Actinopterygii CABZ01044136.1 34
  • 82 (a)
OneToMany
wdr26b 33 34
  • 74.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006042 33
  • 59.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7611 33 34
  • 57.21 (n)
worm
(Caenorhabditis elegans)
Secernentea Y39H10A.6 33 34
  • 41.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GID7 34
  • 18 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G43920 33
  • 49.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2798 34
  • 56 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04101 33
  • 47.87 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC343.04c 33
  • 45.28 (n)
Species where no ortholog for WDR26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR26 Gene

ENSEMBL:
Gene Tree for WDR26 (if available)
TreeFam:
Gene Tree for WDR26 (if available)

Paralogs for WDR26 Gene

(2) SIMAP similar genes for WDR26 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR26: view

No data available for Paralogs for WDR26 Gene

Variants for WDR26 Gene

Sequence variations from dbSNP and Humsavar for WDR26 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs150512167 pathogenic, SKRABAN-DEARDORFF SYNDROME 224,424,520(-) A/C/G coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs796052140 uncertain-significance, Long QT syndrome 224,431,492(-) C/A 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs796052210 uncertain-significance, Long QT syndrome 224,434,047(-) C/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant
VAR_079298 Skraban-Deardorff syndrome (SKDEAS) [MIM:617616] p.Trp172Arg
VAR_079299 Skraban-Deardorff syndrome (SKDEAS) [MIM:617616] p.Leu215Pro

Structural Variations from Database of Genomic Variants (DGV) for WDR26 Gene

Variant ID Type Subtype PubMed ID
nsv8868 CNV loss 18304495
nsv508062 OTHER sequence alteration 20534489
nsv475735 CNV novel sequence insertion 20440878
nsv469889 CNV gain 16826518
nsv160255 CNV deletion 16902084
dgv149e212 CNV loss 25503493

Variation tolerance for WDR26 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR26 Gene

Human Gene Mutation Database (HGMD)
WDR26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR26 Gene

Disorders for WDR26 Gene

MalaCards: The human disease database

(3) MalaCards diseases for WDR26 Gene - From: HGMD, OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
skraban-deardorff syndrome
  • skdeas
klebsiella infection
  • klebsiella
chromosome 1q41-q42 deletion syndrome
  • holoprosencephaly 10, included; hpe10, included
- elite association - COSMIC cancer census association via MalaCards
Search WDR26 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WDR26_HUMAN
  • Skraban-Deardorff syndrome (SKDEAS) [MIM:617616]: An autosomal dominant syndrome characterized by psychomotor developmental delay, intellectual disability with delayed speech, febrile and non-febrile seizures, abnormal gait, and facial dysmorphism. Facial features include a prominent maxilla and upper lip that readily reveal the upper gingiva, widely spaced teeth, and a broad nasal tip. {ECO:0000269 PubMed:28686853}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for WDR26

genes like me logo Genes that share disorders with WDR26: view

No data available for Genatlas for WDR26 Gene

Publications for WDR26 Gene

  1. WDR26 Haploinsufficiency Causes a Recognizable Syndrome of Intellectual Disability, Seizures, Abnormal Gait, and Distinctive Facial Features. (PMID: 28686853) Skraban CM … Deardorff MA (American journal of human genetics 2017) 3 4 58
  2. WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway. (PMID: 27098453) Goto T … Shibuya H (FEBS letters 2016) 3 4 58
  3. Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion. (PMID: 26895380) Ye Y … Chen S (Oncotarget 2016) 3 4 58
  4. WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes. (PMID: 23625927) Sun Z … Chen S (The Journal of biological chemistry 2013) 3 4 58
  5. The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration. (PMID: 22065575) Sun Z … Chen S (The Journal of biological chemistry 2011) 3 4 58

Products for WDR26 Gene

Sources for WDR26 Gene

Content
Loading form....