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Aliases for WDR25 Gene

Aliases for WDR25 Gene

  • WD Repeat Domain 25 2 3 5
  • WD Repeat-Containing Protein 25 3 4
  • C14orf67 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Chromosome 14 Open Reading Frame 67 2

External Ids for WDR25 Gene

Previous HGNC Symbols for WDR25 Gene

  • C14orf67

Previous GeneCards Identifiers for WDR25 Gene

  • GC14P099921
  • GC14P100995
  • GC14P101008
  • GC14P081024
  • GC14P101023
  • GC14P101034
  • GC14P101052
  • GC14P101078
  • GC14P101115
  • GC14P101164
  • GC14P101226
  • GC14P100377
  • GC14P100378
  • GC14P100390
  • GC14P100379
  • GC14P100380
  • GC14P100381
  • GC14P100382
  • GC14P100383
  • GC14P100384
  • GC14P100385
  • GC14P100386

Summaries for WDR25 Gene

Entrez Gene Summary for WDR25 Gene

  • This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GeneCards Summary for WDR25 Gene

WDR25 (WD Repeat Domain 25) is a Protein Coding gene. An important paralog of this gene is CDC40.

Additional gene information for WDR25 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR25 Gene

Genomics for WDR25 Gene

GeneHancer (GH) Regulatory Elements for WDR25 Gene

Promoters and enhancers for WDR25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100371 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 623.8 -1.5 -1488 6.5 SP1 ZFX ELF3 CTCF MNT ZNF148 NKRF MLLT1 CEBPG POLR2A WARS WDR25 SLC25A29 CCNK MEG9 YY1 ENSG00000258581
GH14J100381 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 612.9 +5.1 5084 1.4 PKNOX1 ZIC2 ZBTB20 ZNF189 WDR25 SLC25A29 WARS GC14P100399
GH14J100405 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 35.2 +32.0 31974 5.8 ELF3 CBFA2T2 CEBPG TFE3 TRIM24 SP7 PRDM1 ZNF644 ZNF639 SMARCA4 ENSG00000258620 LOC105370664 WDR25 WARS SLC25A47 GC14P104074 HMGN1P25
GH14J100339 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.8 -34.9 -34852 3.9 ZNF687 RELA SP1 PRDM1 IKZF1 ZNF600 IKZF2 POLR2A DPF2 JUND ENSG00000258521 WARS WDR25 SLC25A29 ENSG00000258666 GC14M100323
GH14J100423 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.4 +47.7 47689 3.8 ZNF473 ZNF148 SP7 ZNF639 SMARCA4 POLR2A PKNOX1 DPF2 ZBTB8A ZIC2 WDR25 WARS BEGAIN SLC25A47 LOC105370664 HMGN1P25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR25 gene promoter:
  • HNF-4alpha1
  • STAT1
  • STAT1alpha

Genomic Locations for WDR25 Gene

Genomic Locations for WDR25 Gene
chr14:100,376,417-100,530,303
(GRCh38/hg38)
Size:
153,887 bases
Orientation:
Plus strand
chr14:100,842,755-100,996,640
(GRCh37/hg19)
Size:
153,886 bases
Orientation:
Plus strand

Genomic View for WDR25 Gene

Genes around WDR25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR25 Gene

Proteins for WDR25 Gene

  • Protein details for WDR25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q64LD2-WDR25_HUMAN
    Recommended name:
    WD repeat-containing protein 25
    Protein Accession:
    Q64LD2
    Secondary Accessions:
    • A8K7E5
    • Q6NVV6
    • Q86TQ4
    • Q9BTK5

    Protein attributes for WDR25 Gene

    Size:
    544 amino acids
    Molecular mass:
    60161 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR25 Gene

Post-translational modifications for WDR25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR25 Gene

Domains & Families for WDR25 Gene

Gene Families for WDR25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WDR25 Gene

Suggested Antigen Peptide Sequences for WDR25 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat-containing protein 25 (WDR25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR25: view

No data available for UniProtKB/Swiss-Prot for WDR25 Gene

Function for WDR25 Gene

Phenotypes From GWAS Catalog for WDR25 Gene

Gene Ontology (GO) - Molecular Function for WDR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WDR25: view
genes like me logo Genes that share phenotypes with WDR25: view

Animal Model Products

CRISPR Products

miRNA for WDR25 Gene

miRTarBase miRNAs that target WDR25

Clone Products

  • Applied Biological Materials (abm): Clones for WDR25 - Now 50% OFF >
  • * WDR25 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * WDR25 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR25 Gene

Localization for WDR25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR25 gene
Compartment Confidence
nucleus 3
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR25 Gene

Pathways & Interactions for WDR25 Gene

PathCards logo

SuperPathways for WDR25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR25 Gene

Drugs & Compounds for WDR25 Gene

No Compound Related Data Available

Transcripts for WDR25 Gene

Unigene Clusters for WDR25 Gene

WD repeat domain 25:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for WDR25 - Now 50% OFF >
  • * WDR25 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * WDR25 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for WDR25 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - - - -
SP2:
SP3:

Relevant External Links for WDR25 Gene

GeneLoc Exon Structure for
WDR25
ECgene alternative splicing isoforms for
WDR25

Expression for WDR25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR25 Gene

Protein differential expression in normal tissues from HIPED for WDR25 Gene

This gene is overexpressed in Retina (48.6) and Blymphocyte (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR25 Gene



Protein tissue co-expression partners for WDR25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR25 Gene:

WDR25

SOURCE GeneReport for Unigene cluster for WDR25 Gene:

Hs.497600

mRNA Expression by UniProt/SwissProt for WDR25 Gene:

Q64LD2-WDR25_HUMAN
Tissue specificity: Expressed in heart, muscle, testis, ovary, uterus and prostate.
genes like me logo Genes that share expression patterns with WDR25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR25 Gene

Orthologs for WDR25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR25 35 34
  • 99.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WDR25 35 34
  • 83.58 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr25 17 35 34
  • 81.12 (n)
rat
(Rattus norvegicus)
Mammalia Wdr25l 34
  • 80.05 (n)
cow
(Bos Taurus)
Mammalia WDR25 35 34
  • 79.54 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR25 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR25 35 34
  • 59.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR25 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr25 34
  • 59.42 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100534700 34
  • 58.4 (n)
CABZ01085626.1 35
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC40 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for WDR25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR25 Gene

ENSEMBL:
Gene Tree for WDR25 (if available)
TreeFam:
Gene Tree for WDR25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR25: view image

Paralogs for WDR25 Gene

Paralogs for WDR25 Gene

genes like me logo Genes that share paralogs with WDR25: view

Variants for WDR25 Gene

Sequence variations from dbSNP and Humsavar for WDR25 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs796052162 likely-benign, Long QT syndrome 100,468,038(+) C/A coding_sequence_variant, missense_variant
rs1000015139 -- 100,465,820(+) A/G intron_variant
rs1000019229 -- 100,396,150(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000028268 -- 100,385,882(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000052219 -- 100,463,154(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR25 Gene

Variant ID Type Subtype PubMed ID
dgv1130n106 CNV deletion 24896259
dgv3898n54 CNV loss 21841781
esv1006795 CNV deletion 20482838
esv1346244 CNV insertion 17803354
esv1625148 CNV deletion 17803354
esv1950925 CNV deletion 18987734
esv2669876 CNV deletion 23128226
esv2749109 CNV deletion 23290073
esv2749110 CNV deletion 23290073
esv2749111 CNV deletion 23290073
esv2856680 CNV duplication 24192839
esv3244051 CNV deletion 24192839
esv34023 CNV loss 18971310
esv3552053 CNV deletion 23714750
esv3635506 CNV gain 21293372
esv3635507 CNV loss 21293372
esv3635509 CNV gain 21293372
esv9060 CNV loss 19470904
nsv1069818 CNV deletion 25765185
nsv1120302 CNV tandem duplication 24896259
nsv1125593 CNV tandem duplication 24896259
nsv1138331 CNV deletion 24896259
nsv1138332 CNV deletion 24896259
nsv1151478 CNV deletion 26484159
nsv456427 CNV loss 19166990
nsv478653 CNV novel sequence insertion 20440878
nsv509548 CNV insertion 20534489
nsv521690 CNV loss 19592680
nsv819726 CNV loss 19587683
nsv952240 CNV deletion 24416366
nsv958726 CNV deletion 24416366
nsv974371 CNV duplication 23825009

Variation tolerance for WDR25 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR25 Gene

Disorders for WDR25 Gene

Additional Disease Information for WDR25

No disorders were found for WDR25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR25 Gene

Publications for WDR25 Gene

  1. A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32. (PMID: 15587985) Jin F … Mao Y (Biochemical genetics 2004) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58
  5. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry JR … Ong KK (Nature 2014) 3 58

Products for WDR25 Gene

Sources for WDR25 Gene

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