This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, ap... See more...

Aliases for WDR25 Gene

Aliases for WDR25 Gene

  • WD Repeat Domain 25 2 3 5
  • WD Repeat-Containing Protein 25 3 4
  • C14orf67 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Chromosome 14 Open Reading Frame 67 2
  • MGC4645 2
  • WDR25 5

External Ids for WDR25 Gene

Previous HGNC Symbols for WDR25 Gene

  • C14orf67

Previous GeneCards Identifiers for WDR25 Gene

  • GC14P099921
  • GC14P100995
  • GC14P101008
  • GC14P081024
  • GC14P101023
  • GC14P101034
  • GC14P101052
  • GC14P101078
  • GC14P101115
  • GC14P101164
  • GC14P101226
  • GC14P100377
  • GC14P100378
  • GC14P100390
  • GC14P100392
  • GC14P100396
  • GC14P100398
  • GC14P100379
  • GC14P100380
  • GC14P100381
  • GC14P100382
  • GC14P100383
  • GC14P100384
  • GC14P100385
  • GC14P100386

Summaries for WDR25 Gene

Entrez Gene Summary for WDR25 Gene

  • This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GeneCards Summary for WDR25 Gene

WDR25 (WD Repeat Domain 25) is a Protein Coding gene. An important paralog of this gene is CDC40.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR25 Gene

Genomics for WDR25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WDR25 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR25

Top Transcription factor binding sites by QIAGEN in the WDR25 gene promoter:
  • HNF-4alpha1
  • STAT1
  • STAT1alpha

Genomic Locations for WDR25 Gene

Genomic Locations for WDR25 Gene
153,888 bases
Plus strand
153,886 bases
Plus strand

Genomic View for WDR25 Gene

Genes around WDR25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR25 Gene

Proteins for WDR25 Gene

  • Protein details for WDR25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 25
    Protein Accession:
    Secondary Accessions:
    • A8K7E5
    • Q6NVV6
    • Q86TQ4
    • Q9BTK5

    Protein attributes for WDR25 Gene

    544 amino acids
    Molecular mass:
    60161 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR25 Gene


neXtProt entry for WDR25 Gene

Post-translational modifications for WDR25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR25 Gene

Domains & Families for WDR25 Gene

Gene Families for WDR25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WDR25 Gene

Suggested Antigen Peptide Sequences for WDR25 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat-containing protein 25 (WDR25_HUMAN)
genes like me logo Genes that share domains with WDR25: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR25 Gene

Function for WDR25 Gene

Phenotypes From GWAS Catalog for WDR25 Gene

Gene Ontology (GO) - Molecular Function for WDR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with WDR25: view
genes like me logo Genes that share phenotypes with WDR25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR25

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR25 Gene

Localization for WDR25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR25 gene
Compartment Confidence
nucleus 3
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR25 Gene

Pathways & Interactions for WDR25 Gene

PathCards logo

SuperPathways for WDR25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR25 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR25 Gene

Drugs & Compounds for WDR25 Gene

No Compound Related Data Available

Transcripts for WDR25 Gene

mRNA/cDNA for WDR25 Gene

10 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR25

Alternative Splicing Database (ASD) splice patterns (SP) for WDR25 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - - - -

Relevant External Links for WDR25 Gene

GeneLoc Exon Structure for

Expression for WDR25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR25 Gene

Protein differential expression in normal tissues from HIPED for WDR25 Gene

This gene is overexpressed in Retina (48.6) and Blymphocyte (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR25 Gene

Protein tissue co-expression partners for WDR25 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR25

SOURCE GeneReport for Unigene cluster for WDR25 Gene:


mRNA Expression by UniProt/SwissProt for WDR25 Gene:

Tissue specificity: Expressed in heart, muscle, testis, ovary, uterus and prostate.
genes like me logo Genes that share expression patterns with WDR25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR25 Gene

Orthologs for WDR25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR25 30 31
  • 99.19 (n)
(Canis familiaris)
Mammalia WDR25 30 31
  • 83.58 (n)
(Mus musculus)
Mammalia Wdr25 30 17 31
  • 81.12 (n)
(Rattus norvegicus)
Mammalia Wdr25l 30
  • 80.05 (n)
(Bos Taurus)
Mammalia WDR25 30 31
  • 79.54 (n)
(Monodelphis domestica)
Mammalia WDR25 31
  • 50 (a)
(Gallus gallus)
Aves WDR25 30 31
  • 59.23 (n)
(Anolis carolinensis)
Reptilia WDR25 31
  • 69 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wdr25 30
  • 59.42 (n)
(Danio rerio)
Actinopterygii LOC100534700 30
  • 58.4 (n)
CABZ01085626.1 31
  • 52 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC40 31
  • 17 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
Species where no ortholog for WDR25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for WDR25 Gene

Gene Tree for WDR25 (if available)
Gene Tree for WDR25 (if available)
Evolutionary constrained regions (ECRs) for WDR25: view image

Paralogs for WDR25 Gene

Paralogs for WDR25 Gene

genes like me logo Genes that share paralogs with WDR25: view

Variants for WDR25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR25 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs796052162 Likely Benign: Long QT syndrome 100,468,038(+) C/A MISSENSE_VARIANT
rs2181170 - p.Trp88Arg
rs2273800 - p.His149Arg
rs2273801 - p.Lys59Arg
rs34331240 - p.Thr119Met

Additional dbSNP identifiers (rs#s) for WDR25 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR25 Gene

Variant ID Type Subtype PubMed ID
dgv1130n106 CNV deletion 24896259
dgv3898n54 CNV loss 21841781
esv1006795 CNV deletion 20482838
esv1346244 CNV insertion 17803354
esv1625148 CNV deletion 17803354
esv1950925 CNV deletion 18987734
esv2669876 CNV deletion 23128226
esv2749109 CNV deletion 23290073
esv2749110 CNV deletion 23290073
esv2749111 CNV deletion 23290073
esv2856680 CNV duplication 24192839
esv3244051 CNV deletion 24192839
esv34023 CNV loss 18971310
esv3552053 CNV deletion 23714750
esv3635506 CNV gain 21293372
esv3635507 CNV loss 21293372
esv3635509 CNV gain 21293372
esv9060 CNV loss 19470904
nsv1069818 CNV deletion 25765185
nsv1120302 CNV tandem duplication 24896259
nsv1125593 CNV tandem duplication 24896259
nsv1138331 CNV deletion 24896259
nsv1138332 CNV deletion 24896259
nsv1151478 CNV deletion 26484159
nsv456427 CNV loss 19166990
nsv478653 CNV novel sequence insertion 20440878
nsv509548 CNV insertion 20534489
nsv521690 CNV loss 19592680
nsv819726 CNV loss 19587683
nsv952240 CNV deletion 24416366
nsv958726 CNV deletion 24416366
nsv974371 CNV duplication 23825009

Variation tolerance for WDR25 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR25 Gene

Disorders for WDR25 Gene

Additional Disease Information for WDR25

No disorders were found for WDR25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR25 Gene

Publications for WDR25 Gene

  1. A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32. (PMID: 15587985) Jin F … Mao Y (Biochemical genetics 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for WDR25 Gene

Sources for WDR25 Gene