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Aliases for WDR24 Gene

Aliases for WDR24 Gene

  • WD Repeat Domain 24 2 3 5
  • WD Repeat-Containing Protein 24 3 4
  • C16orf21 3 4
  • Chromosome 16 Open Reading Frame 21 2
  • GATOR Complex Protein WDR24 3
  • JFP7 3

External Ids for WDR24 Gene

Previous HGNC Symbols for WDR24 Gene

  • C16orf21

Previous GeneCards Identifiers for WDR24 Gene

  • GC00U911617
  • GC16M000675
  • GC16M000677
  • GC16M000734
  • GC16M000656
  • GC16M000709
  • GC16M000743
  • GC16M000814
  • GC16M000837
  • GC16M000855
  • GC16M000881
  • GC16M000905

Summaries for WDR24 Gene

GeneCards Summary for WDR24 Gene

WDR24 (WD Repeat Domain 24) is a Protein Coding gene. Among its related pathways are mTOR signaling pathway (KEGG). An important paralog of this gene is WDR59.

UniProtKB/Swiss-Prot for WDR24 Gene

  • As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).

Gene Wiki entry for WDR24 Gene

Additional gene information for WDR24 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR24 Gene

Genomics for WDR24 Gene

GeneHancer (GH) Regulatory Elements for WDR24 Gene

Promoters and enhancers for WDR24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I000689 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 570 +0.4 407 1.7 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 POLR2B WDR24 ENSG00000261659 TELO2 ENSG00000261505 LUC7L WDR90 CRAMP1 ENSG00000260051 IFT140 ENSG00000268836
GH16I001308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 95.2 -620.1 -620105 5.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 UBE2I LOC102723815 WDR90 CRAMP1 TELO2 ENSG00000261505 E4F1 TSC2 ENSG00000260051 IFT140
GH16I001271 Enhancer 1.1 ENCODE 140.1 -581.2 -581177 1.6 PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 ZNF213 ZNF302 ZNF416 KLF13 SP3 CRAMP1 WDR90 IFT140 TELO2 ENSG00000260646 TSC2 ENSG00000261505 E4F1 WDR24 ENSG00000260051
GH16I000981 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 48.2 -290.8 -290752 1.6 ZNF493 ZNF133 SIN3A GLI4 ZNF2 GLIS2 ZNF213 ZNF416 KLF7 ZNF548 ENSG00000260807 LMF1 SOX8 GC16M000980 GC16M000982 GC16P001002 WDR90 CRAMP1 ENSG00000261505 UBE2I
GH16I000586 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.1 +99.5 99517 8.4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 RAB40C GC16M000587 WDR90 ENSG00000261505 ENSG00000260051 WFIKKN1 ENSG00000260954 RHOT2 WASH4P JMJD8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR24 gene promoter:

Genomic Locations for WDR24 Gene

Genomic Locations for WDR24 Gene
chr16:684,622-690,649
(GRCh38/hg38)
Size:
6,028 bases
Orientation:
Minus strand
chr16:734,622-740,444
(GRCh37/hg19)

Genomic View for WDR24 Gene

Genes around WDR24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR24 Gene

Proteins for WDR24 Gene

  • Protein details for WDR24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S15-WDR24_HUMAN
    Recommended name:
    GATOR complex protein WDR24
    Protein Accession:
    Q96S15
    Secondary Accessions:
    • A2IDB8
    • D3DU59
    • Q96GC7
    • Q9H0B7

    Protein attributes for WDR24 Gene

    Size:
    920 amino acids
    Molecular mass:
    101989 Da
    Quaternary structure:
    • Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers (PubMed:23723238). The GATOR2 complex interacts with CASTOR2 and CASTOR1; the interaction is negatively regulated by arginine (PubMed:26972053). The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids (PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190).

    Alternative splice isoforms for WDR24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR24 Gene

Post-translational modifications for WDR24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR24 Gene

Domains & Families for WDR24 Gene

Gene Families for WDR24 Gene

Suggested Antigen Peptide Sequences for WDR24 Gene

Graphical View of Domain Structure for InterPro Entry

Q96S15

UniProtKB/Swiss-Prot:

WDR24_HUMAN :
  • Belongs to the WD repeat WDR24 family.
Family:
  • Belongs to the WD repeat WDR24 family.
genes like me logo Genes that share domains with WDR24: view

Function for WDR24 Gene

Molecular function for WDR24 Gene

UniProtKB/Swiss-Prot Function:
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).

Phenotypes From GWAS Catalog for WDR24 Gene

Gene Ontology (GO) - Molecular Function for WDR24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with WDR24: view

Phenotypes for WDR24 Gene

genes like me logo Genes that share phenotypes with WDR24: view

Animal Model Products

Clone Products

  • Addgene plasmids for WDR24

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR24 Gene

Localization for WDR24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR24 Gene

Lysosome membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR24 gene
Compartment Confidence
lysosome 5
mitochondrion 2
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WDR24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IDA,IEA 28199306
GO:0016020 membrane IEA --
GO:0061700 GATOR2 complex IDA 23723238
genes like me logo Genes that share ontologies with WDR24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WDR24 Gene

Pathways & Interactions for WDR24 Gene

SuperPathways for WDR24 Gene

SuperPathway Contained pathways
1 mTOR signaling pathway (KEGG)
genes like me logo Genes that share pathways with WDR24: view

Pathways by source for WDR24 Gene

1 KEGG pathway for WDR24 Gene

Gene Ontology (GO) - Biological Process for WDR24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0010506 regulation of autophagy IMP 27166823
GO:0032008 positive regulation of TOR signaling IMP 23723238
GO:0034198 cellular response to amino acid starvation IMP 23723238
genes like me logo Genes that share ontologies with WDR24: view

No data available for SIGNOR curated interactions for WDR24 Gene

Drugs & Compounds for WDR24 Gene

No Compound Related Data Available

Transcripts for WDR24 Gene

Unigene Clusters for WDR24 Gene

WD repeat domain 24:
Representative Sequences:

Clone Products

  • Addgene plasmids for WDR24

Alternative Splicing Database (ASD) splice patterns (SP) for WDR24 Gene

No ASD Table

Relevant External Links for WDR24 Gene

GeneLoc Exon Structure for
WDR24
ECgene alternative splicing isoforms for
WDR24

Expression for WDR24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR24 Gene

Protein differential expression in normal tissues from HIPED for WDR24 Gene

This gene is overexpressed in Placenta (13.9), Plasma (13.3), Blymphocyte (10.1), Pancreas (9.7), CD8 Tcells (6.3), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR24 Gene



Protein tissue co-expression partners for WDR24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR24 Gene:

WDR24

SOURCE GeneReport for Unigene cluster for WDR24 Gene:

Hs.459632

Evidence on tissue expression from TISSUES for WDR24 Gene

  • Kidney(4.1)
  • Liver(4.1)
  • Lung(4.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with WDR24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR24 Gene

Orthologs for WDR24 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR24 33 34
  • 89.7 (n)
dog
(Canis familiaris)
Mammalia WDR24 33 34
  • 88.91 (n)
rat
(Rattus norvegicus)
Mammalia Wdr24 33
  • 87 (n)
mouse
(Mus musculus)
Mammalia Wdr24 33 16 34
  • 86.37 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR24 34
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR24 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR24 33 34
  • 82.05 (n)
lizard
(Anolis carolinensis)
Reptilia WDR24 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr24 33
  • 74.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia mgc47001-prov 33
zebrafish
(Danio rerio)
Actinopterygii wdr24 33 34
  • 72.75 (n)
Dr.5400 33
fruit fly
(Drosophila melanogaster)
Insecta CG7609 34 33
  • 51.25 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001159 33
  • 50.14 (n)
worm
(Caenorhabditis elegans)
Secernentea Y32H12A.8 34
  • 3 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTC5 34
  • 10 (a)
OneToMany
RTC1 36
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4F8.11 33
  • 36.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToOne
Species where no ortholog for WDR24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR24 Gene

ENSEMBL:
Gene Tree for WDR24 (if available)
TreeFam:
Gene Tree for WDR24 (if available)

Paralogs for WDR24 Gene

Paralogs for WDR24 Gene

genes like me logo Genes that share paralogs with WDR24: view

Variants for WDR24 Gene

Sequence variations from dbSNP and Humsavar for WDR24 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000709095 -- 688,058(-) T/C/G coding_sequence_variant, intron_variant, missense_variant
rs1001041321 -- 692,495(-) A/G upstream_transcript_variant
rs1001145224 -- 691,073(-) T/C upstream_transcript_variant
rs1001194178 -- 684,298(-) G/C downstream_transcript_variant
rs1001333493 -- 690,549(-) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR24 Gene

Variant ID Type Subtype PubMed ID
dgv454n67 CNV gain 20364138
dgv4825n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457311 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv482183 CNV gain 20164927
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv827480 CNV gain 20364138
nsv827482 CNV loss 20364138
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for WDR24 Gene

Residual Variation Intolerance Score: 7.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.13; 84.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR24 Gene

Disorders for WDR24 Gene

Additional Disease Information for WDR24

No disorders were found for WDR24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR24 Gene

Publications for WDR24 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. (PMID: 28199306) Wolfson RL … Sabatini DM (Nature 2017) 3 4 58
  3. Sestrin2 is a leucine sensor for the mTORC1 pathway. (PMID: 26449471) Wolfson RL … Sabatini DM (Science (New York, N.Y.) 2016) 3 4 58
  4. Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. (PMID: 26586190) Saxton RA … Sabatini DM (Science (New York, N.Y.) 2016) 3 4 58
  5. The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. (PMID: 27166823) Cai W … Lilly MA (PLoS genetics 2016) 3 4 58

Products for WDR24 Gene

  • Addgene plasmids for WDR24

Sources for WDR24 Gene

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