Aliases for WDR20 Gene
External Ids for WDR20 Gene
Previous GeneCards Identifiers for WDR20 Gene
This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
GeneCards Summary for WDR20 Gene
WDR20 (WD Repeat Domain 20) is a Protein Coding gene. Diseases associated with WDR20 include Chromosome 2Q37 Deletion Syndrome and Temple Syndrome. Among its related pathways are Deubiquitination and Metabolism of proteins. An important paralog of this gene is DMWD.
UniProtKB/Swiss-Prot Summary for WDR20 Gene
Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336).