Aliases for WDR18 Gene
Aliases for WDR18 Gene
External Ids for WDR18 Gene
- HGNC: 17956
- Entrez Gene: 57418
- Ensembl: ENSG00000065268
- UniProtKB: Q9BV38
Previous GeneCards Identifiers for WDR18 Gene
- GC19P001059
- GC19P000924
- GC19P000935
- GC19P000757
Summaries for WDR18 Gene
-
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
GeneCards Summary for WDR18 Gene
WDR18 (WD Repeat Domain 18) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol.
UniProtKB/Swiss-Prot for WDR18 Gene
-
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR18 Gene
Genomics for WDR18 Gene
GeneHancer (GH) Regulatory Elements for WDR18 Gene
Promoters and enhancers for WDR18 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around WDR18 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for WDR18 Gene
Genomic Locations for WDR18 Gene
- chr19:984,271-998,438
- (GRCh38/hg38)
- Size:
- 14,168 bases
- Orientation:
- Plus strand
- chr19:983,174-994,569
- (GRCh37/hg19)
Genomic View for WDR18 Gene
Genes around WDR18 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC
WDR18 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WDR18 Gene
Proteins for WDR18 Gene
-
Protein details for WDR18 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BV38-WDR18_HUMAN
- Recommended name:
- WD repeat-containing protein 18
- Protein Accession:
- Q9BV38
- O60390
- Q9BWR2
Protein attributes for WDR18 Gene
- Size:
- 432 amino acids
- Molecular mass:
- 47405 Da
- Quaternary structure:
-
- Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles (PubMed:21326211).
- SequenceCaution:
-
- Sequence=AAC12679.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for WDR18 Gene
Post-translational modifications for WDR18 Gene
Other Protein References for WDR18 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for WDR18
-
Abcam antibodies for WDR18
- Invitrogen Antibodies for WDR18
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-
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Protein Products
-
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-
Quality Products:
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-
Abcam proteins for WDR18
Assay Products
No data available for DME Specific Peptides for WDR18 Gene
Domains & Families for WDR18 Gene
Gene Families for WDR18 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for WDR18 Gene
Suggested Antigen Peptide Sequences for WDR18 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BV38- Family:
-
- Belongs to the WD repeat IPI3/WDR18 family.
Function for WDR18 Gene
Molecular function for WDR18 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).
Phenotypes From GWAS Catalog for WDR18 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21326211 |
Phenotypes for WDR18 Gene
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for WDR18 gene
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-
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miRNA for WDR18 Gene
- miRTarBase miRNAs that target WDR18
miRNA Products
- Search ViGene Biosciences for WDR18
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for WDR18
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for WDR18
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for WDR18 gene
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR18 Gene
Localization for WDR18 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WDR18 Gene
- Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250 UniProtKB:Q4VBE8}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for WDR18 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for WDR18 Gene
4 Reactome pathways for WDR18 Gene
Interacting Proteins for WDR18 Gene
Selected Interacting proteins:
ENSP00000251289
Q9BV38-WDR18_HUMAN
for WDR18 Gene via
STRING
UniProtKB
IID
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006364 | rRNA processing | TAS | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for SIGNOR curated interactions for WDR18 Gene
Transcripts for WDR18 Gene
mRNA/cDNA for WDR18 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (368) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for WDR18
- genomics-online: gRNA clones - Search results for 122 available WDR18 gene related products
- Overview of 122 available WDR18 gene related products
- Applied Biological Materials CRISPR for WDR18
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for WDR18
- GenScript: Design CRISPR guide RNA sequences for WDR18
miRNA Products
- Search ViGene Biosciences for WDR18
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for WDR18
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- genomics-online: shRNA clones - Search results for 122 available WDR18 gene related products
- Overview of 122 available WDR18 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for WDR18 gene
Clone Products
- Sino Biological Human cDNA Clone for WDR18
- VectorBuilder custom plasmid, inducible vectors for WDR18
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WDR18
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for WDR18
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 |
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| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for WDR18 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (10.1) and Fetal ovary (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR18 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of WDR18 Gene:
WDR18SOURCE GeneReport for Unigene cluster for WDR18 Gene:
Hs.325321Evidence on tissue expression from TISSUES for WDR18 Gene
- Nervous system(4.6)
- Lung(4.5)
Primer Products
-
OriGene qPCR primer pairs for WDR18
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR18 Gene
Orthologs for WDR18 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | WDR18 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | WDR18 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | WDR18 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Wdr18 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Wdr18 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | WDR18 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | WDR18 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | WDR18 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | wdr18 33 |
|
||
| Str.6423 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5262 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | wdr18 33 34 |
|
||
| wufa16f06 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000479 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG14805 33 34 |
|
||
| EG:63B12.7 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | pro-1 33 34 |
|
||
| R166.4 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IPI3 36 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8986 34 |
|
OneToOne |
- Species where no ortholog for WDR18 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for WDR18 Gene
(2) SIMAP similar genes for WDR18 Gene using alignment to 7 proteins:
No data available for Paralogs for WDR18 Gene
Variants for WDR18 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000117872 | -- | 982,469(+) | GCTACTCGGGAGGCT/GCT | upstream_transcript_variant | |
| rs1000234749 | -- | 988,049(+) | C/T | intron_variant | |
| rs1000343742 | -- | 983,504(+) | C/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000455136 | -- | 981,078(+) | G/A | upstream_transcript_variant | |
| rs1000507062 | -- | 981,511(+) | C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2145472 | CNV | deletion | 18987734 |
| esv2717815 | CNV | deletion | 23290073 |
| esv2717816 | CNV | deletion | 23290073 |
| esv2717817 | CNV | deletion | 23290073 |
| esv2758743 | CNV | gain+loss | 17122850 |
| esv3643380 | CNV | loss | 21293372 |
| esv3643381 | CNV | gain | 21293372 |
| nsv1160555 | CNV | deletion | 26073780 |
| nsv138364 | CNV | deletion | 16902084 |
| nsv469845 | CNV | loss | 16826518 |
| nsv470101 | CNV | loss | 18288195 |
| nsv578188 | CNV | loss | 21841781 |
| nsv833704 | CNV | gain | 17160897 |
| nsv953938 | CNV | deletion | 24416366 |
| nsv9662 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.35;
85.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WDR18 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- WDR18
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR18 Gene
Disorders for WDR18 Gene
Additional Disease Information for WDR18
No disorders were found for WDR18 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR18 Gene
Publications for WDR18 Gene
- LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. (PMID: 22190735) Castle CD … Denicourt C (Molecular biology of the cell 2012) 2 3 58
- The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex. (PMID: 21326211) Finkbeiner E … Muller S (The EMBO journal 2011) 3 4 58
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for WDR18 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for WDR18
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WDR18
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 34 available WDR18 Antibodies ranked by validation data
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- antibodies-online: Search results for available WDR18 related products ranked by validation data
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- genomics-online: cdna clones - Search results for 122 available WDR18 gene related products
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- Overview of 122 available WDR18 gene related products
Sources for WDR18 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
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