This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal tran... See more...

Aliases for WDR13 Gene

Aliases for WDR13 Gene

  • WD Repeat Domain 13 2 3 5
  • WD Repeat-Containing Protein 13 3 4
  • WDR13 5
  • MG21 3

External Ids for WDR13 Gene

Previous GeneCards Identifiers for WDR13 Gene

  • GC0XP047258
  • GC0XP046716
  • GC0XP047501
  • GC0XP048203
  • GC0XP048332
  • GC0XP048448
  • GC0XP046119

Summaries for WDR13 Gene

Entrez Gene Summary for WDR13 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. A similar protein in mouse is thought to be a negative regulator of the pancreatic beta cell proliferation. Mice lacking this gene exhibit increased pancreatic islet mass and higher serum insulin levels, and are mildly obese. [provided by RefSeq, Nov 2016]

GeneCards Summary for WDR13 Gene

WDR13 (WD Repeat Domain 13) is a Protein Coding gene. Diseases associated with WDR13 include Inclusion Conjunctivitis and Chronic Polyneuropathy. An important paralog of this gene is WDR26.

Additional gene information for WDR13 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDR13 Gene

Genomics for WDR13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WDR13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDR13

Top Transcription factor binding sites by QIAGEN in the WDR13 gene promoter:
  • AREB6
  • ARP-1
  • FOXO1
  • FOXO1a
  • Ik-1
  • Nkx5-1
  • RORalpha1
  • ZIC2
  • Zic3

Genomic Locations for WDR13 Gene

Genomic Locations for WDR13 Gene
chrX:48,590,042-48,608,869
(GRCh38/hg38)
Size:
18,828 bases
Orientation:
Plus strand
chrX:48,448,430-48,463,582
(GRCh37/hg19)
Size:
15,153 bases
Orientation:
Plus strand

Genomic View for WDR13 Gene

Genes around WDR13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR13 Gene

Proteins for WDR13 Gene

  • Protein details for WDR13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1Z4-WDR13_HUMAN
    Recommended name:
    WD repeat-containing protein 13
    Protein Accession:
    Q9H1Z4
    Secondary Accessions:
    • Q06DW8
    • Q06DX0
    • Q06DX1
    • Q9BUL7
    • Q9NWW4

    Protein attributes for WDR13 Gene

    Size:
    485 amino acids
    Molecular mass:
    53696 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR13 Gene

Post-translational modifications for WDR13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR13 Gene

Domains & Families for WDR13 Gene

Gene Families for WDR13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR13 Gene

Suggested Antigen Peptide Sequences for WDR13 Gene

GenScript: Design optimal peptide antigens:
  • WDR13 (Q06DW8_HUMAN)
  • WDR13 (Q06DW9_HUMAN)
  • WDR13 (Q06DX0_HUMAN)
  • MG21 protein (Q14827_HUMAN)
  • WDR13 protein (Q6NXG4_HUMAN)
genes like me logo Genes that share domains with WDR13: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WDR13 Gene

Function for WDR13 Gene

Gene Ontology (GO) - Molecular Function for WDR13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:1990841 promoter-specific chromatin binding IEA --
genes like me logo Genes that share ontologies with WDR13: view
genes like me logo Genes that share phenotypes with WDR13: view

Animal Models for WDR13 Gene

MGI Knock Outs for WDR13:

Animal Model Products

CRISPR Products

miRNA for WDR13 Gene

miRTarBase miRNAs that target WDR13

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR13

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR13 Gene

Localization for WDR13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR13 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytoskeleton 4
mitochondrion 2
cytosol 2
extracellular 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Centriolar satellite (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0034451 centriolar satellite IDA --
genes like me logo Genes that share ontologies with WDR13: view

Pathways & Interactions for WDR13 Gene

PathCards logo

SuperPathways for WDR13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1904691 negative regulation of type B pancreatic cell proliferation IEA --
genes like me logo Genes that share ontologies with WDR13: view

No data available for Pathways by source and SIGNOR curated interactions for WDR13 Gene

Drugs & Compounds for WDR13 Gene

No Compound Related Data Available

Transcripts for WDR13 Gene

mRNA/cDNA for WDR13 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR13

Alternative Splicing Database (ASD) splice patterns (SP) for WDR13 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a ·
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - - - - - - - - -
SP5: - - -
SP6: - - - -
SP7: - -
SP8: -
SP9: - - - - - -
SP10: - - -
SP11: - - - - - - -
SP12:
SP13:

ExUns: 12b ^ 13a · 13b · 13c · 13d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for WDR13 Gene

GeneLoc Exon Structure for
WDR13

Expression for WDR13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR13 Gene

This gene is overexpressed in Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR13 Gene



Protein tissue co-expression partners for WDR13 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDR13

SOURCE GeneReport for Unigene cluster for WDR13 Gene:

Hs.521973

mRNA Expression by UniProt/SwissProt for WDR13 Gene:

Q9H1Z4-WDR13_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for WDR13 Gene

  • Nervous system(4.8)
  • Stomach(4.3)
  • Intestine(4.3)
  • Pancreas(2.4)
  • Muscle(2.3)
  • Lung(2.3)
  • Heart(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with WDR13: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR13 Gene

Orthologs for WDR13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WDR13 30 31
  • 99.86 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WDR13 30 31
  • 92.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WDR13 30 31
  • 92.03 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Wdr13 30 17 31
  • 90.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wdr13 30
  • 89.82 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia WDR13 31
  • 83 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WDR13 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WDR13 30 31
  • 73.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WDR13 31
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15354 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.13608 30
Zebrafish
(Danio rerio)
Actinopterygii wdr13 30 31
  • 74.69 (n)
OneToOne
wufa04f02 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 57 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2089 30
Species where no ortholog for WDR13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for WDR13 Gene

ENSEMBL:
Gene Tree for WDR13 (if available)
TreeFam:
Gene Tree for WDR13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR13: view image

Paralogs for WDR13 Gene

Paralogs for WDR13 Gene

(1) SIMAP similar genes for WDR13 Gene using alignment to 5 proteins:

  • WDR13_HUMAN
  • Q06DW8_HUMAN
  • Q06DW9_HUMAN
  • Q06DX0_HUMAN
  • Q6NXG4_HUMAN
genes like me logo Genes that share paralogs with WDR13: view

Variants for WDR13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDR13 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
691467 Uncertain Significance: Pyloric stenosis; Esophageal atresia 48,601,863(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
715468 Likely Benign: not provided 48,601,934(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
727016 Likely Benign: not provided 48,600,377(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
729038 Benign: not provided 48,600,491(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
732879 Likely Benign: not provided 48,599,665(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for WDR13 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR13 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV gain+loss 17666407
nsv528292 CNV gain 19592680

Variation tolerance for WDR13 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR13 Gene

Human Gene Mutation Database (HGMD)
WDR13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR13

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR13 Gene

Disorders for WDR13 Gene

MalaCards: The human disease database

(3) MalaCards diseases for WDR13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inclusion conjunctivitis
  • adult inclusion conjunctivitis
chronic polyneuropathy
3-methylglutaconic aciduria, type i
  • mgca1
- elite association - COSMIC cancer census association via MalaCards
Search WDR13 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR13

genes like me logo Genes that share disorders with WDR13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR13 Gene

Publications for WDR13 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A highly conserved human gene encoding a novel member of WD-repeat family of proteins (WDR13). (PMID: 12659815) Singh BN … Singh L (Genomics 2003) 3 4
  4. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for WDR13 Gene

Sources for WDR13 Gene