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Aliases for WDR12 Gene

Aliases for WDR12 Gene

  • WD Repeat Domain 12 2 3 5
  • WD Repeat-Containing Protein 12 3 4
  • Ribosome Biogenesis Protein WDR12 3
  • YTM1 3

External Ids for WDR12 Gene

Previous GeneCards Identifiers for WDR12 Gene

  • GC02M201962
  • GC02M202469
  • GC02M203709
  • GC02M203947
  • GC02M203570
  • GC02M203453
  • GC02M195592

Summaries for WDR12 Gene

Entrez Gene Summary for WDR12 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]

GeneCards Summary for WDR12 Gene

WDR12 (WD Repeat Domain 12) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include ribonucleoprotein complex binding. An important paralog of this gene is WDR37.

UniProtKB/Swiss-Prot for WDR12 Gene

  • Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Gene Wiki entry for WDR12 Gene

Additional gene information for WDR12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR12 Gene

Genomics for WDR12 Gene

GeneHancer (GH) Regulatory Elements for WDR12 Gene

Promoters and enhancers for WDR12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I203013 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.7 -693 4 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 NBEAL1 WDR12 RPL7P14
GH02I202910 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.1 +102.8 102797 3.2 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF207 CARF GC02M202910 WDR12 NBEAL1 NOP58 RPL12P16 CYP20A1 GC02M202888
GH02I202965 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.9 +49.1 49055 1.2 PKNOX1 ATF1 ARNT SIN3A IRF4 ATF7 RUNX3 JUNB ZNF592 MEF2D NBEAL1 CARF NOP58 WDR12 FZD7 RAPH1 ICA1L GC02M202945 GC02P202987
GH02I202669 Enhancer 0.8 ENCODE dbSUPER 10.2 +344.6 344619 1.1 PKNOX1 BMI1 KLF5 ZBTB40 ZNF217 ZSCAN5C ATF7 ZNF24 PRDM10 RUNX3 GC02P202683 FAM117B CARF WDR12 ALS2 GC02M202548
GH02I202932 Enhancer 0.3 ENCODE 11.1 +81.8 81825 1.4 STAT1 NBEAL1 CARF WDR12 LOC100887068 GC02M202945
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR12 gene promoter:

Genomic Locations for WDR12 Gene

Genomic Locations for WDR12 Gene
140,017 bases
Minus strand

Genomic View for WDR12 Gene

Genes around WDR12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR12 Gene

Proteins for WDR12 Gene

  • Protein details for WDR12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosome biogenesis protein WDR12
    Protein Accession:
    Secondary Accessions:
    • B3KPA9
    • Q96HU0
    • Q9NV80
    • Q9NYI8

    Protein attributes for WDR12 Gene

    423 amino acids
    Molecular mass:
    47708 Da
    Quaternary structure:
    • Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (ECO:0000269 PubMed:16043514, ECO:0000269 PubMed:16738141, PubMed:17189298, ECO:0000269 PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome (By similarity). Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain) (PubMed:26601951).

neXtProt entry for WDR12 Gene

Post-translational modifications for WDR12 Gene

Other Protein References for WDR12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR12 Gene

Domains & Families for WDR12 Gene

Gene Families for WDR12 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR12/YTM1 family.
  • Belongs to the WD repeat WDR12/YTM1 family.
genes like me logo Genes that share domains with WDR12: view

Function for WDR12 Gene

Molecular function for WDR12 Gene

UniProtKB/Swiss-Prot Function:
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
UniProtKB/Swiss-Prot Induction:

Phenotypes From GWAS Catalog for WDR12 Gene

Gene Ontology (GO) - Molecular Function for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16043514
GO:0043021 ribonucleoprotein complex binding IEA --
genes like me logo Genes that share ontologies with WDR12: view
genes like me logo Genes that share phenotypes with WDR12: view

Animal Models for WDR12 Gene

MGI Knock Outs for WDR12:

Animal Model Products

miRNA for WDR12 Gene

miRTarBase miRNAs that target WDR12

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR12 Gene

Localization for WDR12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR12 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR12 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 16043514
GO:0030687 preribosome, large subunit precursor IDA 17353269
GO:0070545 PeBoW complex IDA 16043514
genes like me logo Genes that share ontologies with WDR12: view

Pathways & Interactions for WDR12 Gene

genes like me logo Genes that share pathways with WDR12: view

Gene Ontology (GO) - Biological Process for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 16043514
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 16043514
GO:0006364 rRNA processing TAS --
GO:0007219 Notch signaling pathway IEA --
GO:0008283 cell proliferation IMP 16043514
genes like me logo Genes that share ontologies with WDR12: view

No data available for SIGNOR curated interactions for WDR12 Gene

Drugs & Compounds for WDR12 Gene

No Compound Related Data Available

Transcripts for WDR12 Gene

Unigene Clusters for WDR12 Gene

WD repeat domain 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -

Relevant External Links for WDR12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR12 Gene

Protein differential expression in normal tissues from HIPED for WDR12 Gene

This gene is overexpressed in CD8 Tcells (11.0), Testis (8.2), Peripheral blood mononuclear cells (6.4), and Lung (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR12 Gene

Protein tissue co-expression partners for WDR12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR12 Gene:


SOURCE GeneReport for Unigene cluster for WDR12 Gene:


Evidence on tissue expression from TISSUES for WDR12 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with WDR12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR12 Gene

Orthologs for WDR12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR12 33 34
  • 99.92 (n)
(Canis familiaris)
Mammalia WDR12 33 34
  • 92.67 (n)
(Bos Taurus)
Mammalia WDR12 33 34
  • 92.51 (n)
(Mus musculus)
Mammalia Wdr12 33 16 34
  • 89.6 (n)
(Ornithorhynchus anatinus)
Mammalia WDR12 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Wdr12 33
  • 88.49 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
-- 34
  • 74 (a)
(Gallus gallus)
Aves WDR12 34 33
  • 78.64 (n)
(Anolis carolinensis)
Reptilia WDR12 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr12 33
  • 74.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6134 33
(Danio rerio)
Actinopterygii wdr12 33 34
  • 73.22 (n)
wufb24f09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4439 33
African malaria mosquito
(Anopheles gambiae)
Insecta WDR12_ANOGA 33
  • 51.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6724 35 33 34
  • 50.46 (n)
(Caenorhabditis elegans)
Secernentea tag-345 33 34
  • 44.87 (n)
F55F8.5 35
  • 31 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07425g 33
  • 45.54 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTM1 33 34 36
  • 45.12 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER337W 33
  • 42.91 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15550 33
  • 47 (n)
(Oryza sativa)
Liliopsida Os07g0600400 33
  • 46.53 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC890.04c 33
  • 42.69 (n)
Species where no ortholog for WDR12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR12 Gene

Gene Tree for WDR12 (if available)
Gene Tree for WDR12 (if available)

Paralogs for WDR12 Gene

Paralogs for WDR12 Gene Pseudogenes for WDR12 Gene

genes like me logo Genes that share paralogs with WDR12: view

Variants for WDR12 Gene

Sequence variations from dbSNP and Humsavar for WDR12 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000062238 -- 202,880,295(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000190725 -- 202,906,641(-) A/G intron_variant
rs1000411836 -- 202,880,616(-) T/G 3_prime_UTR_variant
rs1000458841 -- 202,903,927(-) C/T intron_variant
rs1000785151 -- 202,891,879(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR12 Gene

Variant ID Type Subtype PubMed ID
nsv1001799 CNV gain 25217958
esv3594003 CNV gain 21293372

Variation tolerance for WDR12 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR12 Gene

Disorders for WDR12 Gene

Additional Disease Information for WDR12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WDR12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR12 Gene

Publications for WDR12 Gene

  1. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. (PMID: 17353269) Rohrmoser M … Eick D (Molecular and cellular biology 2007) 2 3 4 58
  2. Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (PMID: 16043514) Hölzel M … Eick D (The Journal of cell biology 2005) 2 3 4 58
  3. The Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase Midasin. (PMID: 26601951) Romes EM … Stanley RE (The Journal of biological chemistry 2016) 3 4 58
  4. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H … Samani NJ (Nature genetics 2011) 3 44 58
  5. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PMID: 20971364) Ripatti S … Kathiresan S (Lancet (London, England) 2010) 3 44 58

Products for WDR12 Gene

Sources for WDR12 Gene

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