Free for academic non-profit institutions. Other users need a Commercial license

WDR11 Gene(Protein Coding)

WD Repeat Domain 11

GCID:
GC10P120851
GIFtS:
46
Genes Participants
UDN Logo

Aliases for WDR11 Gene

Aliases for WDR11 Gene

  • WD Repeat Domain 11 2 3 5
  • Bromodomain And WD Repeat-Containing Protein 2 3 4
  • Sensitization To Ricin Complex Subunit 1 2 3
  • WD Repeat-Containing Protein 15 3 4
  • BRWD2 3 4
  • WDR15 3 4
  • Bromodomain And WD Repeat Domain Containing 2 2
  • WD Repeat-Containing Protein 11 3
  • WD Repeat Domain 15 3
  • KIAA1351 4
  • DR11 3
  • HH14 3
  • SRI1 3

External Ids for WDR11 Gene

Previous HGNC Symbols for WDR11 Gene

  • BRWD2

Previous GeneCards Identifiers for WDR11 Gene

  • GC10P121529
  • GC10P121854
  • GC10P122741
  • GC10P122275
  • GC10P122600
  • GC10P116240
  • GC10P122610

Summaries for WDR11 Gene

Entrez Gene Summary for WDR11 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR11 Gene

WDR11 (WD Repeat Domain 11) is a Protein Coding gene. Diseases associated with WDR11 include Hypogonadotropic Hypogonadism 14 With Or Without Anosmia and Normosmic Congenital Hypogonadotropic Hypogonadism.

Gene Wiki entry for WDR11 Gene

Additional gene information for WDR11 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR11 Gene

Genomics for WDR11 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for WDR11 Gene

Promoters and enhancers for WDR11 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10I120850 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 628.1 +0.6 592 2.5 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZC3H11A ZFP41 WDR11 WDR11-AS1 SEC23IP MCMBP ENSG00000271670
GH10I121497 Enhancer 0.9 dbSUPER 69.5 +650.0 649983 8.1 PKNOX1 FEZF1 GLIS2 ZNF213 ZNF214 ZNF662 TSHZ1 ZNF491 GLIS1 ZNF624 WDR11 NSMCE4A RN7SKP167 FGFR2
GH10I121307 Enhancer 1 ENCODE 46.5 +457.6 457587 3.1 PKNOX1 ARNT ZNF133 FEZF1 ZNF2 ZNF121 GLIS2 ZNF213 ZNF302 KLF7 WDR11 NSMCE4A ATE1 LOC105378523 GC10M121233
GH10I120948 Enhancer 1 Ensembl ENCODE 41.1 +98.5 98480 1.6 RB1 KLF17 SIN3A FEZF1 ZNF2 RAD21 GLIS2 ZNF143 ZNF391 ZNF202 WDR11 ENSG00000224250 LOC105378518 GC10P120938 LOC105378519
GH10I121332 Enhancer 0.6 ENCODE 34.7 +482.1 482083 1.8 SMARCE1 ZNF449 ZNF529 GATAD2B DPF2 ZNF670 ZNF514 CTBP1 GATA3 ZNF747 WDR11 NSMCE4A RPL21P16 ATE1-AS1 LOC105378523 GC10M121343
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR11 on UCSC Golden Path with GeneCards custom track

Genomic Locations for WDR11 Gene

Genomic Locations for WDR11 Gene
chr10:120,851,175-120,909,526
(GRCh38/hg38)
Size:
58,352 bases
Orientation:
Plus strand
chr10:122,610,687-122,669,038
(GRCh37/hg19)

Genomic View for WDR11 Gene

Genes around WDR11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WDR11 Gene

Proteins for WDR11 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for WDR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZH6-WDR11_HUMAN
    Recommended name:
    WD repeat-containing protein 11
    Protein Accession:
    Q9BZH6
    Secondary Accessions:
    • Q5VWA1
    • Q9P2J6

    Protein attributes for WDR11 Gene

    Size:
    1224 amino acids
    Molecular mass:
    136685 Da
    Quaternary structure:
    • Interacts with EMX1 (via the N-terminal and the central portion of the protein. The C-terminus does not.).
    SequenceCaution:
    • Sequence=BAA92589.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR11 Gene

Protein Expression for WDR11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WDR11 Gene

  • Ubiquitination at isoforms=608, isoforms=900, and isoforms=1, 21193

Other Protein References for WDR11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR11 Gene

Domains & Families for WDR11 Gene

Gene Families for WDR11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for WDR11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WDR11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR11: view

No data available for UniProtKB/Swiss-Prot for WDR11 Gene

Function for WDR11 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for WDR11 Gene

Gene Ontology (GO) - Molecular Function for WDR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20887964
genes like me logo Genes that share ontologies with WDR11: view
genes like me logo Genes that share phenotypes with WDR11: view

Human Phenotype Ontology for WDR11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR11 Gene

Localization for WDR11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR11 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Nucleus. Note=Might be shuttling between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR11 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
lysosome 5
nucleus 4
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 20887964
GO:0005765 lysosomal membrane HDA,IDA 17897319
GO:0005829 cytosol IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with WDR11: view

Pathways & Interactions for WDR11 Gene

SuperPathways for WDR11 Gene

PathCards logo More details on SuperPathways for WDR11
No Data Available

Gene Ontology (GO) - Biological Process for WDR11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR11 Gene

Drugs & Compounds for WDR11 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for WDR11 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for WDR11 Gene

(8) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(251) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR11 Gene

WD repeat domain 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR11 Gene

No ASD Table

Relevant External Links for WDR11 Gene

GeneLoc Exon Structure for
WDR11
ECgene alternative splicing isoforms for
WDR11

Expression for WDR11 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR11 Gene

mRNA expression in normal human tissues for WDR11 Gene
mRNA expression by BioGPS for WDR11 GenemRNA expression by GTEx for WDR11 Gene

Protein differential expression in normal tissues from HIPED for WDR11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9) and Testis (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR11 Gene



Protein tissue co-expression partners for WDR11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR11 Gene:

WDR11

SOURCE GeneReport for Unigene cluster for WDR11 Gene:

Hs.144447

mRNA Expression by UniProt/SwissProt for WDR11 Gene:

Q9BZH6-WDR11_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for WDR11 Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Blood(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR11 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • face
  • head
  • hypothalamus
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • olfactory bulb
  • pharynx
  • pituitary gland
  • skull
  • vocal cord
Thorax:
  • breast
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • kidney
Pelvis:
  • fallopian tube
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with WDR11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR11 Gene

Orthologs for WDR11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia WDR11 33 34
  • 99.78 (n)
cow
(Bos Taurus)
 Mammalia BRWD2 34
  • 96 (a)
 OneToOne
WDR11 33
  • 91.19 (n)
oppossum
(Monodelphis domestica)
 Mammalia WDR11 34
  • 92 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia WDR11 33 34
  • 91.39 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia WDR11 34
  • 90 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Wdr11 33
  • 87.63 (n)
mouse
(Mus musculus)
 Mammalia Wdr11 33 16 34
  • 87.29 (n)
chicken
(Gallus gallus)
 Aves WDR11 33 34
  • 78.75 (n)
lizard
(Anolis carolinensis)
 Reptilia WDR11 34
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia wdr11 33
  • 71.28 (n)
Str.9308 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.2767 33
zebrafish
(Danio rerio)
 Actinopterygii wdr11 33 34
  • 70.46 (n)
worm
(Caenorhabditis elegans)
 Secernentea Y110A7A.9 33 34
  • 44.5 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT3G33530 33
  • 40.61 (n)
rice
(Oryza sativa)
 Liliopsida Os02g0137000 33
  • 41.64 (n)
Species where no ortholog for WDR11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR11 Gene

ENSEMBL:
Gene Tree for WDR11 (if available)
TreeFam:
Gene Tree for WDR11 (if available)

Paralogs for WDR11 Gene

(1) SIMAP similar genes for WDR11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WDR11: view

No data available for Paralogs for WDR11 Gene

Variants for WDR11 Gene

Sequence variations from dbSNP and Humsavar for WDR11 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs139007744 not-provided, not provided, Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858] 120,906,788(+) T/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs144440500 not-provided, not provided, Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858] 120,871,218(+) G/A 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs201051480 not-provided, not provided, Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858] 120,866,757(+) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs318240760 pathogenic, not-provided, Hypogonadotropic hypogonadism 14 with or without anosmia, not provided, Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858] 120,871,178(+) G/A/C 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs318240761 not-provided, not provided, Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858] 120,886,785(+) T/A coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR11 Gene

Variant ID Type Subtype PubMed ID
nsv7573 CNV insertion 18451855
nsv525609 CNV loss 19592680
nsv473863 CNV novel sequence insertion 20440878
nsv428239 CNV gain+loss 18775914
nsv1043485 CNV loss 25217958
esv3624737 CNV gain 21293372
esv3579148 CNV loss 25503493
esv3406416 CNV insertion 20981092
esv3305638 CNV mobile element insertion 20981092
esv2759784 CNV loss 17122850

Variation tolerance for WDR11 Gene

Residual Variation Intolerance Score: 5.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR11 Gene

Human Gene Mutation Database (HGMD)
WDR11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR11 Gene

Disorders for WDR11 Gene

MalaCards: The human disease database

(8) MalaCards diseases for WDR11 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search WDR11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WDR11_HUMAN
  • Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:20887964}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving WDR11 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with ZNF320.
  • Note=A chromosomal aberration involving WDR11 is found in a form of Kallmann syndrome. Translocation 46,XY,t(10;12)(q26.12;q13.11).

Additional Disease Information for WDR11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WDR11: view

No data available for Genatlas for WDR11 Gene

Publications for WDR11 Gene

  1. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. (PMID: 11536051) Chernova OB … Cowell JK (Oncogene 2001) 2 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. (PMID: 23394947) Bassik MC … Weissman JS (Cell 2013) 2 3 58
  4. WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. (PMID: 20887964) Kim HG … Layman LC (American journal of human genetics 2010) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58

Products for WDR11 Gene

Sources for WDR11 Gene

Content
Loading form....