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This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
WDR1 (WD Repeat Domain 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Hypertrophy Model. Gene Ontology (GO) annotations related to this gene include actin binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003779 | actin binding | IEA | -- |
GO:0005515 | protein binding | IEA | -- |
GO:0051015 | actin filament binding | ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002102 | podosome | IEA | -- |
GO:0005576 | extracellular region | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005856 | cytoskeleton | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
2 | Hypertrophy Model |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002446 | neutrophil mediated immunity | IEA | -- |
GO:0002576 | platelet degranulation | TAS | -- |
GO:0007605 | sensory perception of sound | TAS | 10036186 |
GO:0008360 | regulation of cell shape | IEA | -- |
GO:0030036 | actin cytoskeleton organization | IEA | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | WDR1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | WDR1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | WDR1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | WDR1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | WDR1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Wdr1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Wdr1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | WDR1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | WDR1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wdr1 30 |
|
||
Str.11460 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | wdr1 30 |
|
||
WDR1 31 |
|
OneToOne | |||
-- 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002509 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | flr 30 31 |
|
OneToOne | |
CG10724 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | aipl-1 30 31 |
|
OneToMany | |
K08F9.2 32 |
|
|
|||
unc-78 31 32 |
|
OneToMany | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ABL043W 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F13750g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AIP1 30 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G18060 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0125800 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03944 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC9G1.05 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9254 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711389 | Benign: not provided | 10,116,242(-) | G/C | INTRON_VARIANT | |
721980 | Likely Benign: not provided | 10,081,348(-) | G/A | INTRON_VARIANT | |
722768 | Likely Benign: not provided | 10,097,855(-) | A/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
737152 | Likely Benign: not provided | 10,097,759(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
738527 | Likely Benign: not provided | 10,083,054(-) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5117n100 | CNV | gain | 25217958 |
esv24360 | CNV | gain+loss | 19812545 |
esv2752052 | CNV | gain | 17911159 |
esv2759222 | CNV | gain+loss | 17122850 |
esv3575678 | CNV | gain | 25503493 |
esv3599589 | CNV | gain | 21293372 |
esv3599598 | CNV | gain | 21293372 |
esv989430 | CNV | deletion | 20482838 |
nsv1003286 | CNV | gain | 25217958 |
nsv1005698 | CNV | gain | 25217958 |
nsv1013487 | CNV | gain | 25217958 |
nsv1014335 | CNV | gain | 25217958 |
nsv1074689 | CNV | deletion | 25765185 |
nsv428438 | CNV | gain | 18775914 |
nsv469621 | CNV | loss | 16826518 |
nsv524687 | CNV | gain | 19592680 |
nsv525589 | CNV | loss | 19592680 |
nsv829857 | CNV | gain | 17160897 |
No disorders were found for WDR1 Gene.