Aliases for WDPCP Gene
External Ids for WDPCP Gene
Previous HGNC Symbols for WDPCP Gene
Previous GeneCards Identifiers for WDPCP Gene
This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for WDPCP Gene
WDPCP (WD Repeat Containing Planar Cell Polarity Effector) is a Protein Coding gene. Diseases associated with WDPCP include Congenital Heart Defects, Hamartomas Of Tongue, And Polysyndactyly and Bardet-Biedl Syndrome 15.
UniProtKB/Swiss-Prot Summary for WDPCP Gene
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).