WDPCP Gene (Protein Coding)

WD Repeat Containing Planar Cell Polarity Effector

GC02M063121
GIFtS:
37
This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multip... See more...

Aliases for WDPCP Gene

Aliases for WDPCP Gene

  • WD Repeat Containing Planar Cell Polarity Effector 2 3 5
  • BBS15 2 3 4
  • WD Repeat-Containing And Planar Cell Polarity Effector Protein Fritz Homolog 3 4
  • Ciliogenesis And Planar Polarity Effector 5 2 3
  • Bardet-Biedl Syndrome 15 Protein 3 4
  • C2orf86 3 4
  • CPLANE5 2 3
  • FRITZ 3 4
  • WD Repeat-Containing And Planar Cell Polarity Effector Protein 4
  • WD Repeat-Containing Protein C2orf86 3
  • Chromosome 2 Open Reading Frame 86 2
  • CHDTHP 3
  • WDPCP 5
  • HFrtz 2
  • Fritz 2
  • HFRTZ 4
  • FRTZ 3

External Ids for WDPCP Gene

Previous HGNC Symbols for WDPCP Gene

  • C2orf86

Previous GeneCards Identifiers for WDPCP Gene

  • GC02M063349

Summaries for WDPCP Gene

Entrez Gene Summary for WDPCP Gene

  • This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for WDPCP Gene

WDPCP (WD Repeat Containing Planar Cell Polarity Effector) is a Protein Coding gene. Diseases associated with WDPCP include Congenital Heart Defects, Hamartomas Of Tongue, And Polysyndactyly and Bardet-Biedl Syndrome 15.

UniProtKB/Swiss-Prot Summary for WDPCP Gene

  • Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).

Additional gene information for WDPCP Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDPCP Gene

Genomics for WDPCP Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for WDPCP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J063587 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 256.4 +238.4 238367 6.2 CHD2 TBP ZBTB10 MXD4 SP1 BCL11A FEZF1 CEBPA SIX5 NR2C1 MDH1 WDPCP VPS54 AFTPH HSALNG0015434 lnc-VPS54-7
GH02J063827 Enhancer 1.2 Ensembl ENCODE dbSUPER 250.7 -0.2 -182 1.6 CEBPA HOMEZ THAP11 FOXA2 SMAD4 SAP130 ZEB2 TAL1 MIER3 RARA WDPCP lnc-UGP2-1 lnc-VPS54-7 UGP2
GH02J063484 Promoter 0.7 EPDnew Ensembl 250 +343.1 343142 0.2 WDPCP ENSG00000279485 HSALNG0015423 MDH1 lnc-VPS54-7 OTX1
GH02J064017 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 15.5 -191.2 -191167 3.6 ZBTB10 NR2C1 IKZF1 SMAD5 POLR2A NONO HOMEZ THAP11 ZNF395 REST HSALNG0015445 VPS54 WDPCP ENSG00000225889 UGP2
GH02J063852 Promoter/Enhancer 1 Ensembl ENCODE dbSUPER 25.1 -27.1 -27088 4.3 CEBPA RAD21 ZNF644 ZNF384 HLF WDPCP UGP2 MDH1 ENSG00000251775 piR-56229-043 HSALNG0015441 lnc-VPS54-2 VPS54
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDPCP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDPCP

Genomic Locations for WDPCP Gene

Latest Assembly
chr2:63,119,559-63,827,843
(GRCh38/hg38)
Size:
708,285 bases
Orientation:
Minus strand

Previous Assembly
chr2:63,346,694-63,815,611
(GRCh37/hg19 by Entrez Gene)
Size:
468,918 bases
Orientation:
Minus strand

chr2:63,348,518-64,054,977
(GRCh37/hg19 by Ensembl)
Size:
706,460 bases
Orientation:
Minus strand

Genomic View for WDPCP Gene

Genes around WDPCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDPCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDPCP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WDPCP Gene

Proteins for WDPCP Gene

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  • Protein details for WDPCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95876-FRITZ_HUMAN
    Recommended name:
    WD repeat-containing and planar cell polarity effector protein fritz homolog
    Protein Accession:
    O95876
    Secondary Accessions:
    • Q53RW4
    • Q7Z2Z3

    Protein attributes for WDPCP Gene

    Size:
    746 amino acids
    Molecular mass:
    85084 Da
    Quaternary structure:
    • Interacts with CPLANE1. Interacts with INTU and FUZ; FUZ, INTU and WDPCP probably form the core CPLANE (ciliogenesis and planar polarity effectors) complex.

    Alternative splice isoforms for WDPCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDPCP Gene

Protein Expression for WDPCP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WDPCP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDPCP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDPCP Gene

Domains & Families for WDPCP Gene

Gene Families for WDPCP Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for WDPCP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WDPCP Gene

GenScript: Design optimal peptide antigens:
  • WD repeat-containing and planar cell polarity effector protein (FRITZ_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95876

UniProtKB/Swiss-Prot:

FRITZ_HUMAN :
  • Belongs to the WD repeat fritz family.
Family:
  • Belongs to the WD repeat fritz family.
genes like me logo Genes that share domains with WDPCP: view

Function for WDPCP Gene

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  6. Cell Lines for research

Molecular function for WDPCP Gene

UniProtKB/Swiss-Prot Function:
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).

Phenotypes From GWAS Catalog for WDPCP Gene

Gene Ontology (GO) - Molecular Function for WDPCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with WDPCP: view
genes like me logo Genes that share phenotypes with WDPCP: view

Human Phenotype Ontology for WDPCP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WDPCP Gene

MGI Knock Outs for WDPCP:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDPCP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WDPCP Gene

Localization for WDPCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDPCP Gene

Cell membrane. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDPCP gene
Compartment Confidence
cytoskeleton 4
plasma membrane 3
nucleus 2
cytosol 2
extracellular 1
endoplasmic reticulum 1
endosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDPCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 colocalizes_with plasma membrane IEA,ISS --
GO:0005929 cilium IEA --
GO:0005930 axoneme ISS --
genes like me logo Genes that share ontologies with WDPCP: view

Pathways & Interactions for WDPCP Gene

PathCards logo

SuperPathways for WDPCP Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDPCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0002093 auditory receptor cell morphogenesis IEA --
GO:0007224 smoothened signaling pathway IEA --
GO:0007399 nervous system development IBA 21873635
GO:0010762 regulation of fibroblast migration IEA --
genes like me logo Genes that share ontologies with WDPCP: view

No data available for Pathways by source and SIGNOR curated interactions for WDPCP Gene

Drugs & Compounds for WDPCP Gene

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No Compound Related Data Available

Transcripts for WDPCP Gene

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mRNA/cDNA for WDPCP Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDPCP

Alternative Splicing Database (ASD) splice patterns (SP) for WDPCP Gene

No ASD Table

Relevant External Links for WDPCP Gene

GeneLoc Exon Structure for
WDPCP

Expression for WDPCP Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDPCP Gene

mRNA expression in normal human tissues for WDPCP Gene
mRNA expression by GTEx for WDPCP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDPCP Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDPCP Gene



Protein tissue co-expression partners for WDPCP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDPCP

SOURCE GeneReport for Unigene cluster for WDPCP Gene:

Hs.414952

Evidence on tissue expression from TISSUES for WDPCP Gene

  • Nervous system(4.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WDPCP Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • meninges
  • middle ear
  • mouth
  • neck
  • nose
  • olfactory bulb
  • outer ear
  • pituitary gland
  • skull
  • tongue
  • tooth
Thorax:
  • aorta
  • breast
  • bronchus
  • clavicle
  • esophagus
  • heart
  • heart valve
  • lung
Abdomen:
  • abdominal wall
  • adrenal gland
  • biliary tract
  • duodenum
  • gallbladder
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • ovary
  • pelvis
  • penis
  • placenta
  • prostate
  • rectum
  • testicle
  • ureter
  • urethra
  • urinary bladder
  • uterus
  • vagina
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
General:
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with WDPCP: view

Primer products for research

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDPCP Gene

Orthologs for WDPCP Gene

This gene was present in the common ancestor of animals.

Orthologs for WDPCP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia WDPCP 30 31
  • 99.64 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia WDPCP 30 31
  • 90.17 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia WDPCP 30 31
  • 90.02 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Wdpcp 30
  • 83.71 (n)
Mouse
(Mus musculus)
 Mammalia Wdpcp 30 17 31
  • 83.52 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia WDPCP 31
  • 78 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia WDPCP 31
  • 73 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves WDPCP 30 31
  • 75.6 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia WDPCP 31
  • 62 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia wdpcp 30
  • 68.65 (n)
Str.14230 30
Zebrafish
(Danio rerio)
 Actinopterygii LOC100333125 30
  • 54.56 (n)
wdpcp 31
  • 44 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002252 30
  • 47.41 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta frtz 30 31
  • 42.11 (n)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 42 (a)
 OneToMany
-- 31
  • 36 (a)
 OneToMany
Species where no ortholog for WDPCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for WDPCP Gene

ENSEMBL:
Gene Tree for WDPCP (if available)
TreeFam:
Gene Tree for WDPCP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDPCP: view image

Paralogs for WDPCP Gene

(1) SIMAP similar genes for WDPCP Gene using alignment to 6 proteins:

  • FRITZ_HUMAN
  • C9JDS5_HUMAN
  • E9PFG9_HUMAN
  • F8WBT2_HUMAN
  • H7BZ13_HUMAN
  • H7C375_HUMAN
genes like me logo Genes that share paralogs with WDPCP: view

No data available for Paralogs for WDPCP Gene

Variants for WDPCP Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDPCP Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
834407 Uncertain Significance: Bardet-Biedl syndrome 63,404,641(-) C/T
NM_015910.7(WDPCP):c.842G>A (p.Arg281His) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
838580 Uncertain Significance: Bardet-Biedl syndrome 63,484,654(-) G/C
NM_015910.7(WDPCP):c.334C>G (p.Gln112Glu) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
839601 Uncertain Significance: Bardet-Biedl syndrome 63,378,512(-) G/A
NM_015910.7(WDPCP):c.1625-3C>T 		INTRON
842238 Uncertain Significance: Bardet-Biedl syndrome 63,404,152(-) A/C
NM_015910.7(WDPCP):c.1331T>G (p.Ile444Arg) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
844173 Uncertain Significance: Bardet-Biedl syndrome 63,382,098(-) T/C
NM_015910.7(WDPCP):c.1436-4A>G 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for WDPCP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for WDPCP Gene

Variant ID Type Subtype PubMed ID
dgv3860n100 CNV loss 25217958
dgv705e199 CNV deletion 23128226
esv1071119 CNV insertion 17803354
esv1628034 CNV insertion 17803354
esv2035676 CNV deletion 18987734
esv2479838 CNV insertion 19546169
esv2659646 CNV deletion 23128226
esv2673093 CNV deletion 23128226
esv274907 CNV gain+loss 21479260
esv3386938 CNV insertion 20981092
esv3591050 CNV loss 21293372
esv3591051 CNV loss 21293372
esv3591052 CNV loss 21293372
esv3591053 CNV loss 21293372
esv3591056 CNV loss 21293372
esv3591058 CNV loss 21293372
esv3591059 CNV loss 21293372
nsv1002047 CNV loss 25217958
nsv1004678 CNV loss 25217958
nsv1009191 CNV loss 25217958
nsv2752 CNV insertion 18451855
nsv470468 CNV loss 18288195
nsv477771 CNV novel sequence insertion 20440878
nsv582126 CNV gain 21841781
nsv7313 OTHER inversion 18451855
nsv819228 CNV loss 19587683
nsv834241 CNV gain 17160897
nsv954155 CNV deletion 24416366

Variation tolerance for WDPCP Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDPCP Gene

Human Gene Mutation Database (HGMD)
WDPCP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDPCP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDPCP Gene

Disorders for WDPCP Gene

MalaCards: The human disease database

(25) MalaCards diseases for WDPCP Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search WDPCP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FRITZ_HUMAN
  • Bardet-Biedl syndrome 15 (BBS15) [MIM:615992]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. {ECO:0000269 PubMed:20671153}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Congenital heart defects, hamartomas of tongue, and polysyndactyly (CHDTHP) [MIM:217085]: A disease characterized by a constellation of anomalies including tongue hamartomas, polysyndactyly, and congenital heart defects such as atrioventricular canal and coarctation of the aorta. {ECO:0000269 PubMed:25427950, ECO:0000269 PubMed:27158779}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Note=Mutations in WDPCP may act as modifiers of the phenotypic expression of Bardet-Biedl syndrome and Meckel syndrome by interacting in trans with primary BBS and MKS loci. {ECO:0000269 PubMed:20671153}.

Additional Disease Information for WDPCP

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with WDPCP: view

No data available for Genatlas for WDPCP Gene

Publications for WDPCP Gene

  1. Planar cell polarity acts through septins to control collective cell movement and ciliogenesis. (PMID: 20671153) Kim SK … Wallingford JB (Science (New York, N.Y.) 2010) 2 3 4 74
  2. The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery. (PMID: 27158779) Toriyama M … Wallingford JB (Nature genetics 2016) 3 4 74
  3. Compound heterozygosity for a frame shift mutation and a likely pathogenic sequence variant in the planar cell polarity—ciliogenesis gene WDPCP in a girl with polysyndactyly, coarctation of the aorta, and tongue hamartomas. (PMID: 25427950) Saari J … Bellus GA (American journal of medical genetics. Part A 2015) 4 74
  4. The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis. (PMID: 15654087) Collier S … Adler P (Genetics 2005) 2 3
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

ExternalLinks

View latest publications for WDPCP gene in Mastermind

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