This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008] See more...

Aliases for WDFY2 Gene

Aliases for WDFY2 Gene

  • WD Repeat And FYVE Domain Containing 2 2 3 5
  • WD Repeat And FYVE Domain-Containing Protein 2 3 4
  • Zinc Finger FYVE Domain-Containing Protein 22 3 4
  • WD40- And FYVE Domain-Containing Protein 2 3 4
  • WD40 And FYVE Domain Containing 2 2 3
  • Propeller-FYVE Protein 3 4
  • ZFYVE22 3 4
  • WDF2 3 4
  • PROF 3
  • Prof 4

External Ids for WDFY2 Gene

Previous GeneCards Identifiers for WDFY2 Gene

  • GC13P046146
  • GC13P051095
  • GC13P049956
  • GC13P051056
  • GC13P052158
  • GC13P032948

Summaries for WDFY2 Gene

Entrez Gene Summary for WDFY2 Gene

  • This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDFY2 Gene

WDFY2 (WD Repeat And FYVE Domain Containing 2) is a Protein Coding gene. Diseases associated with WDFY2 include Orange Allergy and Aspirin Allergy. Among its related pathways are Mesodermal Commitment Pathway. An important paralog of this gene is WDFY1.

UniProtKB/Swiss-Prot Summary for WDFY2 Gene

  • Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).

Additional gene information for WDFY2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDFY2 Gene

Genomics for WDFY2 Gene

GeneHancer (GH) Regulatory Elements for WDFY2 Gene

Promoters and enhancers for WDFY2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J051583 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 505.1 +1.0 1007 4.4 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 NCOR1 SIX5 WDFY2 RNY1P6 RF00019-032 ALG11 SERPINE3 piR-51878-007
GH13J051576 Promoter/Enhancer 0.6 EPDnew ENCODE 500.4 -7.3 -7287 0.2 FOS piR-43106-053 WDFY2 piR-51878-007
GH13J051801 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +219.5 219488 4.6 ZBTB40 ZNF217 EP300 MYC POLR2G USF1 NCOR1 GTF2E2 PHF8 ZIC2 DHRS12 ENSG00000231856 lnc-TMEM272-2 UTP14C HNRNPA1L2 WDFY2 INTS6 piR-42272 ENSG00000285444
GH13J051549 Enhancer 1.3 FANTOM5 Ensembl ENCODE 14.4 -33.2 -33193 6.8 NRF1 NCOR1 ZIC2 REST ZBTB7A CTBP1 SKI JUN MYC BCL11A MIR4703 WDFY2 DHRS12 INTS6 piR-59297-158 INTS6-AS1
GH13J051725 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +145.1 145080 7.1 CTCF JUND FOS RFX1 NR2F2 FOXA2 RAD21 FOSL2 CEBPB MEF2B DHRS12 WDFY2 ENSG00000231856 NEK5 CKAP2 RF00017-1432 L13713-063
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDFY2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDFY2

Top Transcription factor binding sites by QIAGEN in the WDFY2 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • GATA-1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • NRSF form 1
  • NRSF form 2

Genomic Locations for WDFY2 Gene

Genomic Locations for WDFY2 Gene
chr13:51,584,194-51,767,709
(GRCh38/hg38)
Size:
183,516 bases
Orientation:
Plus strand
chr13:52,158,484-52,336,171
(GRCh37/hg19)
Size:
177,688 bases
Orientation:
Plus strand

Genomic View for WDFY2 Gene

Genes around WDFY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDFY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDFY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDFY2 Gene

Proteins for WDFY2 Gene

  • Protein details for WDFY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P53-WDFY2_HUMAN
    Recommended name:
    WD repeat and FYVE domain-containing protein 2
    Protein Accession:
    Q96P53
    Secondary Accessions:
    • B1AL86
    • Q96CS1

    Protein attributes for WDFY2 Gene

    Size:
    400 amino acids
    Molecular mass:
    45154 Da
    Quaternary structure:
    • Homodimer (PubMed:16792529). Interacts (via WD repeats 1-3) with AKT1, AKT2, PRKCZ and PRKCI (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with VAMP2 and PRKCZ (PubMed:17313651). Interacts with FOXO1 (By similarity). Forms a complex with AKT1 and FOXO1 (By similarity).

neXtProt entry for WDFY2 Gene

Post-translational modifications for WDFY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDFY2 Gene

No data available for DME Specific Peptides for WDFY2 Gene

Domains & Families for WDFY2 Gene

Gene Families for WDFY2 Gene

Suggested Antigen Peptide Sequences for WDFY2 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger FYVE domain-containing protein 22 (WDFY2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96P53

UniProtKB/Swiss-Prot:

WDFY2_HUMAN :
  • The FYVE-type zinc finger is essential for its vesicular localization.
Domain:
  • The FYVE-type zinc finger is essential for its vesicular localization.
genes like me logo Genes that share domains with WDFY2: view

Function for WDFY2 Gene

Molecular function for WDFY2 Gene

UniProtKB/Swiss-Prot Function:
Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).

Phenotypes From GWAS Catalog for WDFY2 Gene

Gene Ontology (GO) - Molecular Function for WDFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16792529
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with WDFY2: view
genes like me logo Genes that share phenotypes with WDFY2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDFY2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDFY2 Gene

Localization for WDFY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDFY2 Gene

Endosome. Early endosome. Cytoplasm. Note=Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity). {ECO:0000250 UniProtKB:Q8BUB4, ECO:0000269 PubMed:16792529, ECO:0000269 PubMed:17313651}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDFY2 gene
Compartment Confidence
endosome 5
nucleus 3
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WDFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA,IDA 16792529
GO:0031982 vesicle IDA 16792529
genes like me logo Genes that share ontologies with WDFY2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WDFY2 Gene

Pathways & Interactions for WDFY2 Gene

PathCards logo

SuperPathways for WDFY2 Gene

genes like me logo Genes that share pathways with WDFY2: view

Pathways by source for WDFY2 Gene

2 BioSystems pathways for WDFY2 Gene

Gene Ontology (GO) - Biological Process for WDFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 17313651
GO:0045600 positive regulation of fat cell differentiation IMP,IEA 18388859
genes like me logo Genes that share ontologies with WDFY2: view

No data available for SIGNOR curated interactions for WDFY2 Gene

Drugs & Compounds for WDFY2 Gene

(1) Drugs for WDFY2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
methionine sulfoxide Experimental Pharma Target 0
genes like me logo Genes that share compounds with WDFY2: view

Transcripts for WDFY2 Gene

mRNA/cDNA for WDFY2 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDFY2

Alternative Splicing Database (ASD) splice patterns (SP) for WDFY2 Gene

No ASD Table

Relevant External Links for WDFY2 Gene

GeneLoc Exon Structure for
WDFY2

Expression for WDFY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDFY2 Gene

Protein differential expression in normal tissues from HIPED for WDFY2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7), NK cells (8.8), Spleen (8.7), Pancreas (6.6), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDFY2 Gene



Protein tissue co-expression partners for WDFY2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDFY2

SOURCE GeneReport for Unigene cluster for WDFY2 Gene:

Hs.208550

Evidence on tissue expression from TISSUES for WDFY2 Gene

  • Nervous system(2.6)
  • Blood(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with WDFY2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDFY2 Gene

Orthologs for WDFY2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDFY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDFY2 31 30
  • 99.67 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDFY2 31
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdfy2 17 31 30
  • 92.5 (n)
rat
(Rattus norvegicus)
Mammalia Wdfy2 30
  • 91.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDFY2 31
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDFY2 31 30
  • 90.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WDFY2 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDFY2 31 30
  • 84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDFY2 31
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdfy2 30
  • 78.17 (n)
zebrafish
(Danio rerio)
Actinopterygii wdfy2 31 30
  • 75.58 (n)
OneToOne
Dr.18512 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008932 30
  • 58.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5168 31 30
  • 55.03 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea wdfy-2 31 30
  • 51.12 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS27 31
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4999 31
  • 53 (a)
OneToMany
Cin.13448 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13448 30
Species where no ortholog for WDFY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDFY2 Gene

ENSEMBL:
Gene Tree for WDFY2 (if available)
TreeFam:
Gene Tree for WDFY2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDFY2: view image

Paralogs for WDFY2 Gene

(1) SIMAP similar genes for WDFY2 Gene using alignment to 1 proteins:

  • WDFY2_HUMAN
genes like me logo Genes that share paralogs with WDFY2: view

Variants for WDFY2 Gene

Additional dbSNP identifiers (rs#s) for WDFY2 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDFY2 Gene

Variant ID Type Subtype PubMed ID
dgv1652n100 CNV loss 25217958
dgv3146n54 CNV loss 21841781
esv3580640 CNV loss 25503493
esv3892343 CNV gain 25118596
nsv1042 CNV insertion 18451855
nsv1118517 CNV duplication 24896259
nsv1122819 CNV deletion 24896259
nsv472078 CNV novel sequence insertion 20440878
nsv832612 CNV gain 17160897

Variation tolerance for WDFY2 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDFY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDFY2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDFY2 Gene

Disorders for WDFY2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WDFY2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
orange allergy
  • citrus sinensis fruit allergy
aspirin allergy
  • acetylsalicylic acid allergy
- elite association - COSMIC cancer census association via MalaCards
Search WDFY2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDFY2

genes like me logo Genes that share disorders with WDFY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDFY2 Gene

Publications for WDFY2 Gene

  1. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. (PMID: 16873553) Hayakawa A … Corvera S (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 23 54
  2. Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. (PMID: 18388859) Fritzius T … Moelling K (The EMBO journal 2008) 3 4 54
  3. WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. (PMID: 17313651) Fritzius T … Moelling K (The FEBS journal 2007) 3 4 54
  4. A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. (PMID: 16792529) Fritzius T … Moelling K (The Biochemical journal 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for WDFY2 Gene

Sources for WDFY2 Gene