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The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015] See more...
Aliases for WDFY1 Gene
Aliases for WDFY1 Gene
External Ids for WDFY1 Gene
- HGNC: 20451
- Entrez Gene: 57590
- Ensembl: ENSG00000085449
- OMIM: 618080
- UniProtKB: Q8IWB7
Previous GeneCards Identifiers for WDFY1 Gene
- GC02M223461
- GC02M224704
- GC02M224942
- GC02M224565
- GC02M224448
- GC02M216592
Summaries for WDFY1 Gene
-
The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]
GeneCards Summary for WDFY1 Gene
WDFY1 (WD Repeat And FYVE Domain Containing 1) is a Protein Coding gene. Diseases associated with WDFY1 include Melanoma, Cutaneous Malignant 1. Gene Ontology (GO) annotations related to this gene include 1-phosphatidylinositol binding. An important paralog of this gene is WDFY2.
UniProtKB/Swiss-Prot Summary for WDFY1 Gene
-
Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).
Additional gene information for WDFY1 Gene
- HGNC(20451)
- Entrez Gene(57590)
- Ensembl(ENSG00000085449)
- OMIM(618080)
- UniProtKB(Q8IWB7)
- Open Targets Platform(ENSG00000085449)
- Search for WDFY1 at DataMed
- Search for WDFY1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WDFY1 Gene
Genomics for WDFY1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for WDFY1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around WDFY1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WDFY1
- Top Transcription factor binding sites by QIAGEN in the WDFY1 gene promoter:
-
- AML1a
- AP-1
- c-Fos
- c-Jun
- c-Myb
- C/EBPalpha
- CUTL1
- GATA-1
- Ik-1
- ZID
Genomic Locations for WDFY1 Gene
Genomic Locations for WDFY1 Gene
- chr2:223,855,716-223,945,357
- (GRCh38/hg38)
- Size:
- 89,642 bases
- Orientation:
- Minus strand
- chr2:224,720,433-224,810,104
- (GRCh37/hg19)
- Size:
- 89,672 bases
- Orientation:
- Minus strand
Genomic View for WDFY1 Gene
Genes around WDFY1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.1 by HGNC
- 2q36.1 by Entrez Gene
- 2q36.1 by Ensembl
WDFY1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WDFY1 Gene
Proteins for WDFY1 Gene
-
Protein details for WDFY1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IWB7-WDFY1_HUMAN
- Recommended name:
- WD repeat and FYVE domain-containing protein 1
- Protein Accession:
- Q8IWB7
- Q53S17
- Q9H9D5
- Q9P2B3
Protein attributes for WDFY1 Gene
- Size:
- 410 amino acids
- Molecular mass:
- 46324 Da
- Quaternary structure:
-
- Binds PtdIns3P in vitro with high specificity over other phosphoinositides. Interacts (via WD repeat 2) with tyrosine-phosphorylated TLR3 (via TIR domain) in response to poly(I:C) (PubMed:25736436). Interacts with TICAM1 in response to poly(I:C) (By similarity). Interacts with TLR4 in response to LPS (By similarity).
- SequenceCaution:
-
- Sequence=BAA92673.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for WDFY1 Gene
Post-translational modifications for WDFY1 Gene
Other Protein References for WDFY1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences WDFY1 Antibody (LS-B11629) and WDFY1 Antibody (LS-B12648)
- GeneTex Anti-FENS1 antibody and Anti-FENS1 antibody [C3], C-term
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-
Abcam antibodies for WDFY1
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Protein Products
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- antibodies-online: Show 4 available WDFY1 Proteins ranked by validation data
- Compare Top WDFY1 Proteins
-
Quality Products:
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Signalway Proteins for WDFY1
-
Abcam proteins for WDFY1
No data available for DME Specific Peptides for WDFY1 Gene
Domains & Families for WDFY1 Gene
Gene Families for WDFY1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for WDFY1 Gene
- InterPro:
- Blocks:
-
- Zn-finger, FYVE type
- ProtoNet:
Suggested Antigen Peptide Sequences for WDFY1 Gene
- GenScript: Design optimal peptide antigens:
-
- WD repeat and FYVE domain containing 1, isoform CRA_a (Q53S17_HUMAN)
- Zinc finger FYVE domain-containing protein 17 (WDFY1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8IWB7UniProtKB/Swiss-Prot:
WDFY1_HUMAN :- The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions. The FYVE domain is required for its function in regulating TLR3 signaling (PubMed:25736436).
- Domain:
-
- The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions. The FYVE domain is required for its function in regulating TLR3 signaling (PubMed:25736436).
Function for WDFY1 Gene
Molecular function for WDFY1 Gene
- UniProtKB/Swiss-Prot Function:
- Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).
Phenotypes From GWAS Catalog for WDFY1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 25736436 |
| GO:0005545 | 1-phosphatidylinositol binding | IDA | 11739631 |
| GO:0008270 | zinc ion binding | NAS | 11739631 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for WDFY1 Gene
- GenomeRNAi human phenotypes for WDFY1:
-
- no effect
- Dynamic nuclei (hole, folded or small irregular)
- Increased NF-kappaB reporter expression
- Increased epidermal growth factor receptor (EGFR) surface abundance
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
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miRNA for WDFY1 Gene
- miRTarBase miRNAs that target WDFY1
-
- hsa-miR-1-3p (MIRT001322)
- hsa-miR-155-5p (MIRT001486)
- hsa-miR-1301-3p (MIRT036051)
- mmu-miR-129-1-3p (MIRT596734)
- mmu-miR-129-2-3p (MIRT596735)
- mmu-miR-3064-5p (MIRT596736)
- mmu-miR-3085-3p (MIRT596737)
- mmu-miR-201-5p (MIRT596738)
- hsa-miR-3911 (MIRT711943)
- hsa-miR-4800-5p (MIRT711944)
- hsa-miR-3138 (MIRT711945)
- hsa-miR-27a-3p (MIRT726110)
- hsa-miR-27b-3p (MIRT726111)
- hsa-miR-2115-5p (MIRT763814)
- hsa-miR-2355-5p (MIRT764001)
- hsa-miR-3613-3p (MIRT766008)
- hsa-miR-3977 (MIRT767914)
- hsa-miR-516a-3p (MIRT773455)
- hsa-miR-516b-3p (MIRT773460)
- hsa-miR-5195-5p (MIRT773632)
- hsa-miR-7162-5p (MIRT781696)
miRNA Products
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Clone Products
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products
-
Horizon Cell Lines for WDFY1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDFY1 Gene
Localization for WDFY1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WDFY1 Gene
- Early endosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| endosome | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 11739631 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | IEA,IDA | 11739631 |
| GO:0005829 | cytosol | IDA | 11739631 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for WDFY1 Gene
Pathways & Interactions for WDFY1 Gene
Interacting Proteins for WDFY1 Gene
GPS-Prot Interaction Network for WDFY1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0034141 | positive regulation of toll-like receptor 3 signaling pathway | IMP | 25736436 |
| GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway | IMP | 25736436 |
No data available for Pathways by source and SIGNOR curated interactions for WDFY1 Gene
Transcripts for WDFY1 Gene
mRNA/cDNA for WDFY1 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000233055 4607 nts (view in UCSC)
- ENST00000429915 719 nts (view in UCSC)
- ENST00000462702 361 nts (view in UCSC)
- ENST00000483061 864 nts (view in UCSC)
- ENST00000491453 308 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WDFY1 - Select products 50% OFF >
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-
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WDFY1
-
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miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WDFY1
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Clone Products
- Applied Biological Materials (abm): Clones for WDFY1 - Select products 50% OFF >
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- MG204332
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- RC209030L2V
- RC209030L3V
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- RR215002L3V
- RR215002L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for WDFY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WDFY1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for WDFY1 Gene
- GeneLoc Exon Structure for
- WDFY1
Expression for WDFY1 Gene
This gene is overexpressed in Urinary Bladder (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDFY1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WDFY1
SOURCE GeneReport for Unigene cluster for WDFY1 Gene:
Hs.368359Evidence on tissue expression from TISSUES for WDFY1 Gene
- Nervous system(4.7)
- Skin(4.6)
Primer Products
-
OriGene qPCR primer pairs for WDFY1
-
OriGene qPCR primer pairs and template standards for WDFY1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDFY1 Gene
Orthologs for WDFY1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | WDFY1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | WDFY1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | WDFY1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | WDFY1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | WDFY1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Wdfy1 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | WDFY1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | WDFY1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wdfy1 30 |
|
||
| Str.11442 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | wdfy1 30 31 |
|
OneToOne | |
| Dr.3787 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG5168 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | wdfy-2 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS27 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4999 31 |
|
OneToMany |
- Species where no ortholog for WDFY1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for WDFY1 Gene
- ENSEMBL:
- Gene Tree for WDFY1 (if available)
- TreeFam:
- Gene Tree for WDFY1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WDFY1: view image
Paralogs for WDFY1 Gene
Variants for WDFY1 Gene
Residual Variation Intolerance Score:
32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.03;
21.18% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WDFY1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- WDFY1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WDFY1 Gene
Disorders for WDFY1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma, cutaneous malignant 1 |
|
|
Search WDFY1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for WDFY1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for WDFY1 Gene
Publications for WDFY1 Gene
- FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. (PMID: 11739631) Ridley SH … Hawkins PT (Journal of cell science 2001) 2 3 4
- WDFY1 mediates TLR3/4 signaling by recruiting TRIF. (PMID: 25736436) Hu YH … Liu Y (EMBO reports 2015) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4
ExternalLinks
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- VectorBuilder Viral vectors for WDFY1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for WDFY1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for WDFY1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for WDFY1
- antibodies-online: Show 5 available WDFY1 Antibodies ranked by validation data
- Compare Top WDFY1 Antibodies
- antibodies-online: Search results for available WDFY1 related products ranked by validation data
- antibodies-online: Show 4 available WDFY1 Proteins ranked by validation data
- Compare Top WDFY1 Proteins
- Quality Products:
- Horizon Cell Lines for WDFY1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WDFY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WDFY1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for WDFY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDFY1
- Signalway Proteins for WDFY1
Sources for WDFY1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB