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The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]
WDFY1 (WD Repeat And FYVE Domain Containing 1) is a Protein Coding gene. Diseases associated with WDFY1 include Melanoma, Cutaneous Malignant 1. Gene Ontology (GO) annotations related to this gene include 1-phosphatidylinositol binding. An important paralog of this gene is WDFY2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 25736436 |
GO:0005545 | 1-phosphatidylinositol binding | IDA | 11739631 |
GO:0008270 | zinc ion binding | NAS | 11739631 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 11739631 |
GO:0005768 | endosome | IEA | -- |
GO:0005769 | early endosome | IEA,IDA | 11739631 |
GO:0005829 | cytosol | IDA | 11739631 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0034141 | positive regulation of toll-like receptor 3 signaling pathway | IMP | 25736436 |
GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway | IMP | 25736436 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | WDFY1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | WDFY1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | WDFY1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | WDFY1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | WDFY1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Wdfy1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | WDFY1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | WDFY1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wdfy1 30 |
|
||
Str.11442 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | wdfy1 30 31 |
|
OneToOne | |
Dr.3787 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5168 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | wdfy-2 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS27 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4999 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
melanoma, cutaneous malignant 1 |
|
|