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Aliases for WDCP Gene

Aliases for WDCP Gene

  • WD Repeat And Coiled Coil Containing 2 3 5
  • C2orf44 3 4
  • WD Repeat And Coiled-Coil-Containing Protein C2orf44 3
  • WD Repeat And Coiled-Coil-Containing Protein 3
  • WD Repeat-Containing Protein C2orf44 3
  • Chromosome 2 Open Reading Frame 44 2
  • PP384 3

External Ids for WDCP Gene

Previous HGNC Symbols for WDCP Gene

  • C2orf44

Summaries for WDCP Gene

GeneCards Summary for WDCP Gene

WDCP (WD Repeat And Coiled Coil Containing) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway.

Additional gene information for WDCP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDCP Gene

Genomics for WDCP Gene

GeneHancer (GH) Regulatory Elements for WDCP Gene

Promoters and enhancers for WDCP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I024045 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 580.2 +2.6 2642 2.5 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 WDCP RNU6-370P FAM228B ATAD2B PFN4 ENSG00000271936 FAM228A MFSD2B GC02P023754
GH02I024048 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 -0.3 -316 1.8 ELF3 ARID4B KLF17 ZNF2 ZNF48 ZNF335 ZNF121 GLIS2 ZNF366 ZNF391 WDCP FKBP1B FAM228B SF3B6 MFSD2B TP53I3 ATAD2B UBXN2A PFN4 GC02M024079
GH02I024791 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.1 -743.8 -743839 4.8 HDGF SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 PTRHD1 CENPO LOC105369164 ATAD2B DNMT3A ITSN2 WDCP FAM228B ADCY3 NCOA1
GH02I024970 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.5 -922.7 -922660 3.6 CLOCK ZFP64 DMAP1 YY1 ZNF213 SP3 NFYC GLIS1 RCOR2 NBN DNAJC27 DNAJC27-AS1 ADCY3 ASXL2 WDCP EFR3B LINC01381 POMC PTRHD1 ENSG00000207069
GH02I024082 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -34.4 -34414 3.6 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TP53I3 FAM228B ATAD2B PFN4 WDCP ENSG00000271936 FAM228A GC02P023754
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDCP on UCSC Golden Path with GeneCards custom track

Genomic Locations for WDCP Gene

Genomic Locations for WDCP Gene
chr2:24,029,336-24,049,575
(GRCh38/hg38)
Size:
20,240 bases
Orientation:
Minus strand
chr2:24,252,206-24,272,445
(GRCh37/hg19)

Genomic View for WDCP Gene

Genes around WDCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDCP Gene

Proteins for WDCP Gene

  • Protein details for WDCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6R7-WDCP_HUMAN
    Recommended name:
    WD repeat and coiled-coil-containing protein
    Protein Accession:
    Q9H6R7
    Secondary Accessions:
    • D6W532
    • Q8IYK0
    • Q9HBP5

    Protein attributes for WDCP Gene

    Size:
    721 amino acids
    Molecular mass:
    79136 Da
    Quaternary structure:
    • Oligomer. Interacts with HCK (via SH3 domain).

    Alternative splice isoforms for WDCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDCP Gene

Post-translational modifications for WDCP Gene

Other Protein References for WDCP Gene

No data available for DME Specific Peptides for WDCP Gene

Domains & Families for WDCP Gene

Gene Families for WDCP Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for WDCP Gene

Suggested Antigen Peptide Sequences for WDCP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDCP: view

No data available for UniProtKB/Swiss-Prot for WDCP Gene

Function for WDCP Gene

Gene Ontology (GO) - Molecular Function for WDCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019900 kinase binding IPI 25469238
genes like me logo Genes that share ontologies with WDCP: view

Phenotypes for WDCP Gene

genes like me logo Genes that share phenotypes with WDCP: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDCP Gene

Localization for WDCP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDCP gene
Compartment Confidence
nucleus 3
cytosol 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDCP Gene

Pathways & Interactions for WDCP Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with WDCP: view

Pathways by source for WDCP Gene

1 BioSystems pathway for WDCP Gene

Gene Ontology (GO) - Biological Process for WDCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051259 protein oligomerization IDA 25469238
genes like me logo Genes that share ontologies with WDCP: view

No data available for SIGNOR curated interactions for WDCP Gene

Drugs & Compounds for WDCP Gene

No Compound Related Data Available

Transcripts for WDCP Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDCP Gene

No ASD Table

Relevant External Links for WDCP Gene

GeneLoc Exon Structure for
WDCP
ECgene alternative splicing isoforms for
WDCP

Expression for WDCP Gene

NURSA nuclear receptor signaling pathways regulating expression of WDCP Gene:

WDCP

Evidence on tissue expression from TISSUES for WDCP Gene

  • Eye(4.1)
  • Nervous system(2.9)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDCP Gene

Orthologs for WDCP Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf44 33
  • 99.4 (n)
C2orf44 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17H2orf44 33
  • 81.85 (n)
C2orf44 34
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf44 33
  • 81.37 (n)
C2orf44 34
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC068281 33 34
  • 74.93 (n)
Wdcp 16
rat
(Rattus norvegicus)
Mammalia RGD1563701 33
  • 74.3 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia C2orf44 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC421975 33
  • 60.55 (n)
C2orf44 34
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf44 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf44 33
  • 57.55 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:103511 33
  • 54.6 (n)
C20H2orf44 34
  • 43 (a)
OneToOne
Species where no ortholog for WDCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDCP Gene

ENSEMBL:
Gene Tree for WDCP (if available)
TreeFam:
Gene Tree for WDCP (if available)

Paralogs for WDCP Gene

No data available for Paralogs for WDCP Gene

Variants for WDCP Gene

Sequence variations from dbSNP and Humsavar for WDCP Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_035876 A breast cancer sample p.Pro454Ser
rs1000029386 -- 24,036,180(-) T/C intron_variant
rs1000083777 -- 24,043,561(-) T/C intron_variant
rs1000485936 -- 24,035,968(-) C/T intron_variant
rs1001100524 -- 24,042,754(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDCP Gene

Variant ID Type Subtype PubMed ID
esv3553800 CNV deletion 23714750
nsv997445 CNV gain 25217958

Variation tolerance for WDCP Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDCP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDCP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDCP Gene

Disorders for WDCP Gene

UniProtKB/Swiss-Prot

WDCP_HUMAN
  • Note=A chromosomal aberration involving WDCP is found in one subject with colorectal cancer. Translocation t(2;2)(p23.3;p23.1). A 5 million base pair tandem duplication generates an in-frame WDCP-ALK gene fusion. {ECO:0000269 PubMed:22327622}.

No disorders were found for WDCP Gene.

No data available for MalaCards and Genatlas for WDCP Gene

Publications for WDCP Gene

  1. Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK. (PMID: 25469238) Yokoyama N … Miller WT (Biomedical reports 2015) 2 3 4 58
  2. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. (PMID: 22327622) Lipson D … Stephens PJ (Nature medicine 2012) 2 3 4 58
  3. Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. (PMID: 12029088) Scott MP … Miller WT (The Journal of biological chemistry 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for WDCP Gene

Sources for WDCP Gene

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