This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008] See more...

Aliases for WBP4 Gene

Aliases for WBP4 Gene

  • WW Domain Binding Protein 4 2 3 5
  • FBP21 2 3 4
  • WW Domain-Binding Protein 4 3 4
  • Formin Binding Protein 21 2 3
  • WBP-4 3 4
  • WW Domain-Containing Binding Protein 4 3
  • WW Domain-Containing-Binding Protein 4 4
  • Domain-Containing Binding Protein 4 3
  • Formin-Binding Protein 21 4
  • MGC117310 2
  • FNBP21 4
  • WBP4 5

External Ids for WBP4 Gene

Previous GeneCards Identifiers for WBP4 Gene

  • GC13P039621
  • GC13P035622
  • GC13P040572
  • GC13P039433
  • GC13P040533
  • GC13P041635
  • GC13P022436

Summaries for WBP4 Gene

Entrez Gene Summary for WBP4 Gene

  • This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]

GeneCards Summary for WBP4 Gene

WBP4 (WW Domain Binding Protein 4) is a Protein Coding gene. Diseases associated with WBP4 include Cerebral Amyloid Angiopathy, Itm2b-Related, 2. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proline-rich region binding.

UniProtKB/Swiss-Prot Summary for WBP4 Gene

  • Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750).

Gene Wiki entry for WBP4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WBP4 Gene

Genomics for WBP4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WBP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J041056 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 622.7 -0.2 -216 9.7 ZNF221 SP1 HNRNPL GATAD2A CTCF ATF7 TEAD4 PRDM10 REST ZNF629 WBP4 ELF1 TRE-TTC1-2 NAA16 TPTE2P5 LINC00548 MTRF1 RNU6-57P CYCSP34 lnc-KBTBD6-1
GH13J041014 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.3 -43.4 -43392 8.2 SP1 GATAD2A PRDM10 ZNF629 TFE3 RFX1 LEF1 SOX13 POLR2A BACH1 ELF1 WBP4 SLC25A15 RGCC NAA16 piR-50357-049 RGS17P1
GH13J041001 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 22.8 -56.2 -56167 8.1 SP1 GATAD2A ZNF629 TFE3 LEF1 SOX13 NFKBIZ RCOR2 POLR2A JUND WBP4 ELF1 NAA16 CYCSP34 SLC25A15 RGS17P1 piR-50357-049
GH13J040920 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.7 -139.9 -139853 3.2 BRCA1 CREB1 GATAD2A CTCF PRDM10 ZNF629 REST NFKBIZ ZNF692 POLR2A SUGT1P3 TPTE2P5 lnc-SLC25A15-14 lnc-ELF1-1 MRPS31 NAA16 WBP4 CYCSP34 SLC25A15 lnc-SLC25A15-5
GH13J041025 Enhancer 1 Ensembl ENCODE dbSUPER 24.9 -36.3 -36308 2 GATAD2A SOX13 RXRB FOXA2 CREM FOXP1 SAP130 MIER3 ZMYM3 SMAD4 piR-50357-049 WBP4 ELF1 RGS17P1 SLC25A15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WBP4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WBP4

Top Transcription factor binding sites by QIAGEN in the WBP4 gene promoter:
  • aMEF-2
  • MEF-2A
  • MRF-2
  • Msx-1
  • Nkx2-5
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3

Genomic Locations for WBP4 Gene

Genomic Locations for WBP4 Gene
chr13:41,061,509-41,084,006
(GRCh38/hg38)
Size:
22,498 bases
Orientation:
Plus strand
chr13:41,635,410-41,658,139
(GRCh37/hg19)
Size:
22,730 bases
Orientation:
Plus strand

Genomic View for WBP4 Gene

Genes around WBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP4 Gene

Proteins for WBP4 Gene

  • Protein details for WBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75554-WBP4_HUMAN
    Recommended name:
    WW domain-binding protein 4
    Protein Accession:
    O75554
    Secondary Accessions:
    • B7Z4M2
    • Q32P29

    Protein attributes for WBP4 Gene

    Size:
    376 amino acids
    Molecular mass:
    42507 Da
    Quaternary structure:
    • Component of the spliceosome B complex (PubMed:9724750, PubMed:28781166). Associated with U2 snRNPs (PubMed:9724750, PubMed:28781166). Binds splicing factors SNRPB, SNRPC and SF1 (PubMed:9724750). Interacts via the WW domains with the Pro-rich domains of KHDRBS1/SAM68 (By similarity). Interacts via the WW domains with the Pro-rich domains of WBP11 (PubMed:19592703).

    Three dimensional structures from OCA and Proteopedia for WBP4 Gene

    Alternative splice isoforms for WBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WBP4 Gene

Post-translational modifications for WBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WBP4 Gene

Domains & Families for WBP4 Gene

Gene Families for WBP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WBP4 Gene

Suggested Antigen Peptide Sequences for WBP4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52917, highly similar to WW domain-binding protein 4 (B7Z4M2_HUMAN)
  • WW domain-containing-binding protein 4 (WBP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75554

UniProtKB/Swiss-Prot:

WBP4_HUMAN :
  • The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins.
Domain:
  • The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins.
genes like me logo Genes that share domains with WBP4: view

Function for WBP4 Gene

Molecular function for WBP4 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750).
GENATLAS Biochemistry:
WW domain binding protein 4, formin binding 21,general spliceosomal protein binding a third class of proline-glycine methionine (PGM) rich motif

Phenotypes From GWAS Catalog for WBP4 Gene

Gene Ontology (GO) - Molecular Function for WBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0005515 protein binding IPI 17500595
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with WBP4: view
genes like me logo Genes that share phenotypes with WBP4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WBP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP4 Gene

Localization for WBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WBP4 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WBP4 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 28781166
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0016607 nuclear speck IEA,IDA 19592703
GO:0071005 U2-type precatalytic spliceosome IDA 28781166
genes like me logo Genes that share ontologies with WBP4: view

Pathways & Interactions for WBP4 Gene

genes like me logo Genes that share pathways with WBP4: view

Pathways by source for WBP4 Gene

Gene Ontology (GO) - Biological Process for WBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IBA 21873635
GO:0045292 mRNA cis splicing, via spliceosome IDA 19592703
genes like me logo Genes that share ontologies with WBP4: view

No data available for SIGNOR curated interactions for WBP4 Gene

Drugs & Compounds for WBP4 Gene

No Compound Related Data Available

Transcripts for WBP4 Gene

mRNA/cDNA for WBP4 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WBP4

Alternative Splicing Database (ASD) splice patterns (SP) for WBP4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
SP1: -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for WBP4 Gene

GeneLoc Exon Structure for
WBP4

Expression for WBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WBP4 Gene

This gene is overexpressed in Bone (26.0), Blymphocyte (10.1), Peripheral blood mononuclear cells (9.9), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WBP4 Gene



Protein tissue co-expression partners for WBP4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WBP4

SOURCE GeneReport for Unigene cluster for WBP4 Gene:

Hs.411300

Evidence on tissue expression from TISSUES for WBP4 Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with WBP4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WBP4 Gene

Orthologs for WBP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WBP4 30 31
  • 99.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WBP4 30 31
  • 90.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WBP4 30 31
  • 89.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wbp4 30
  • 85.52 (n)
Mouse
(Mus musculus)
Mammalia Wbp4 30 17 31
  • 84 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WBP4 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WBP4 31
  • 56 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WBP4 30 31
  • 65.55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WBP4 31
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wbp4 30
  • 59.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1414 30
Zebrafish
(Danio rerio)
Actinopterygii wbp4 30 31
  • 53.78 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG4291 30 31
  • 45.8 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010339 30
  • 42.9 (n)
Species where no ortholog for WBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for WBP4 Gene

ENSEMBL:
Gene Tree for WBP4 (if available)
TreeFam:
Gene Tree for WBP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WBP4: view image

Paralogs for WBP4 Gene

No data available for Paralogs for WBP4 Gene

Variants for WBP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WBP4 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
768612 Benign: not provided 41,065,241(+) C/T SYNONYMOUS_VARIANT
VAR_036352 A breast cancer sample p.Lys113Arg

Additional dbSNP identifiers (rs#s) for WBP4 Gene

Structural Variations from Database of Genomic Variants (DGV) for WBP4 Gene

Variant ID Type Subtype PubMed ID
esv3580615 CNV loss 25503493
esv3631865 CNV loss 21293372
nsv561538 CNV loss 21841781
nsv832587 CNV gain 17160897

Variation tolerance for WBP4 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WBP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WBP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP4 Gene

Disorders for WBP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WBP4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cerebral amyloid angiopathy, itm2b-related, 2
  • dementia, familial danish; fdd
- elite association - COSMIC cancer census association via MalaCards
Search WBP4 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with WBP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WBP4 Gene

Publications for WBP4 Gene

  1. Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). (PMID: 19592703) Huang X … Shi Y (The Journal of biological chemistry 2009) 3 4 23
  2. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. (PMID: 9724750) Bedford MT … Leder P (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4
  3. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. (PMID: 28781166) Bertram K … Stark H (Cell 2017) 3 4
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for WBP4 Gene

Sources for WBP4 Gene