Aliases for WBP1L Gene

Aliases for WBP1L Gene

  • WW Domain Binding Protein 1 Like 2 3 5
  • Outcome Predictor In Acute Leukemia 1 2 3 4
  • C10orf26 3 4
  • OPA1L 3 4
  • Chromosome 10 Open Reading Frame 26 2
  • WW Domain Binding Protein 1-Like 3
  • OPAL1 3

External Ids for WBP1L Gene

Previous HGNC Symbols for WBP1L Gene

  • C10orf26

Previous GeneCards Identifiers for WBP1L Gene

  • GC10P104504

Summaries for WBP1L Gene

GeneCards Summary for WBP1L Gene

WBP1L (WW Domain Binding Protein 1 Like) is a Protein Coding gene. An important paralog of this gene is WBP1.

Gene Wiki entry for WBP1L Gene

Additional gene information for WBP1L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WBP1L Gene

Genomics for WBP1L Gene

GeneHancer (GH) Regulatory Elements for WBP1L Gene

Promoters and enhancers for WBP1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WBP1L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WBP1L

Genomic Locations for WBP1L Gene

Genomic Locations for WBP1L Gene
chr10:102,739,283-102,834,516
(GRCh38/hg38)
Size:
95,234 bases
Orientation:
Plus strand
chr10:104,503,727-104,576,021
(GRCh37/hg19)
Size:
72,295 bases
Orientation:
Plus strand

Genomic View for WBP1L Gene

Genes around WBP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP1L Gene

Proteins for WBP1L Gene

  • Protein details for WBP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX94-WBP1L_HUMAN
    Recommended name:
    WW domain binding protein 1-like
    Protein Accession:
    Q9NX94
    Secondary Accessions:
    • B3KPF4
    • B7Z6S7
    • D3DR90
    • Q1EG70
    • Q2HIY7
    • Q5F2G6

    Protein attributes for WBP1L Gene

    Size:
    342 amino acids
    Molecular mass:
    37828 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91122.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for WBP1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WBP1L Gene

Post-translational modifications for WBP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WBP1L Gene

No data available for DME Specific Peptides for WBP1L Gene

Domains & Families for WBP1L Gene

Gene Families for WBP1L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for WBP1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WBP1L Gene

GenScript: Design optimal peptide antigens:
  • Outcome predictor in acute leukemia 1 (Q1EG67_HUMAN)
  • Outcome predictor in acute leukemia 1 (Q1EG68_HUMAN)
  • Outcome predictor in acute leukemia 1 (Q1EG69_HUMAN)
genes like me logo Genes that share domains with WBP1L: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WBP1L Gene

Function for WBP1L Gene

Phenotypes From GWAS Catalog for WBP1L Gene

Gene Ontology (GO) - Molecular Function for WBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WBP1L: view
genes like me logo Genes that share phenotypes with WBP1L: view

Animal Models for WBP1L Gene

MGI Knock Outs for WBP1L:
  • Wbp1l Wbp1l<tm2b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WBP1L

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WBP1L Gene

Localization for WBP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for WBP1L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WBP1L gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WBP1L: view

Pathways & Interactions for WBP1L Gene

PathCards logo

SuperPathways for WBP1L Gene

No Data Available

Interacting Proteins for WBP1L Gene

Selected Interacting proteins: Q9NX94-WBP1L_HUMAN for WBP1L Gene via IID

Symbol External ID(s) Details
LIG4
SGTA
;

Gene Ontology (GO) - Biological Process for WBP1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WBP1L Gene

Drugs & Compounds for WBP1L Gene

No Compound Related Data Available

Transcripts for WBP1L Gene

mRNA/cDNA for WBP1L Gene

2 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WBP1L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WBP1L Gene

No ASD Table

Relevant External Links for WBP1L Gene

GeneLoc Exon Structure for
WBP1L

Expression for WBP1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WBP1L Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WBP1L Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WBP1L

SOURCE GeneReport for Unigene cluster for WBP1L Gene:

Hs.500897

Evidence on tissue expression from TISSUES for WBP1L Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with WBP1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WBP1L Gene

Orthologs for WBP1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for WBP1L Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia WBP1L 31 30
  • 91.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia C26H10orf26 30
  • 91.1 (n)
WBP1L 31
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wbp1l 30
  • 89.3 (n)
mouse
(Mus musculus)
Mammalia Wbp1l 17 31 30
  • 87.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WBP1L 31
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WBP1L 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C6H10ORF26 30
  • 74.41 (n)
WBP1L 31
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WBP1L 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wbp1l 30
  • 65.81 (n)
zebrafish
(Danio rerio)
Actinopterygii wbp1la 31 30
  • 58.98 (n)
OneToMany
wbp1lb 31
  • 44 (a)
OneToMany
wufc23g11 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2554 31
  • 33 (a)
OneToMany
Species where no ortholog for WBP1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WBP1L Gene

ENSEMBL:
Gene Tree for WBP1L (if available)
TreeFam:
Gene Tree for WBP1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WBP1L: view image

Paralogs for WBP1L Gene

Paralogs for WBP1L Gene

(1) SIMAP similar genes for WBP1L Gene using alignment to 1 proteins:

  • WBP1L_HUMAN
genes like me logo Genes that share paralogs with WBP1L: view

Variants for WBP1L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WBP1L Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs284859 - p.Ala320Ser
rs284860 - p.Ser302Pro

Additional dbSNP identifiers (rs#s) for WBP1L Gene

Structural Variations from Database of Genomic Variants (DGV) for WBP1L Gene

Variant ID Type Subtype PubMed ID
esv1620062 CNV deletion 17803354
esv2532539 CNV deletion 19546169
esv2672715 CNV deletion 23128226
esv2674595 CNV deletion 23128226
esv2676472 CNV deletion 23128226
esv2740228 CNV deletion 23290073
esv33608 CNV loss 17666407
esv3546764 CNV deletion 23714750
esv3624401 CNV loss 21293372
esv3624403 CNV loss 21293372
nsv1069962 CNV deletion 25765185
nsv1115221 CNV deletion 24896259
nsv1153403 CNV deletion 26484159
nsv474848 CNV novel sequence insertion 20440878
nsv7527 CNV insertion 18451855
nsv831969 CNV loss 17160897
nsv951007 CNV deletion 24416366
nsv955982 CNV deletion 24416366

Variation tolerance for WBP1L Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WBP1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WBP1L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP1L Gene

Disorders for WBP1L Gene

Additional Disease Information for WBP1L

No disorders were found for WBP1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP1L Gene

Publications for WBP1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for WBP1L Gene

Sources for WBP1L Gene