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Aliases for WBP1 Gene

Aliases for WBP1 Gene

  • WW Domain Binding Protein 1 2 3 5
  • WBP-1 3 4
  • WW Domain-Binding Protein 1 3

External Ids for WBP1 Gene

Previous GeneCards Identifiers for WBP1 Gene

  • GC02P074823
  • GC02P074643
  • GC02P074660
  • GC02P074597
  • GC02P074539
  • GC02P074685
  • GC02P074421

Summaries for WBP1 Gene

Entrez Gene Summary for WBP1 Gene

  • The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011]

GeneCards Summary for WBP1 Gene

WBP1 (WW Domain Binding Protein 1) is a Protein Coding gene. Among its related pathways are CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). Gene Ontology (GO) annotations related to this gene include WW domain binding. An important paralog of this gene is WBP1L.

Gene Wiki entry for WBP1 Gene

Additional gene information for WBP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP1 Gene

Genomics for WBP1 Gene

GeneHancer (GH) Regulatory Elements for WBP1 Gene

Promoters and enhancers for WBP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I074454 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 570.8 -1.2 -1221 5.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 WBP1 INO80B PCGF1 TTC31 AUP1 MOGS CCDC142 DUSP11 ENSG00000273245 LBX2
GH02I074196 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 28.3 -259.6 -259582 3.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ENSG00000279070 MTHFD2 PCGF1 DUSP11 INO80B ENSG00000273245 WBP1 AUP1 TTC31 MOB1A
GH02I074119 Promoter/Enhancer 1.6 Ensembl ENCODE 20.5 -338.0 -337967 1.6 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 FNBP1P1 LOC107985899 PCGF1 CCDC142 TTC31 DUSP11 ENSG00000273245 AUP1 MOGS WBP1
GH02I074513 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 20.3 +56.9 56903 3 RING1 SUZ12 MAX NFYC BMI1 REST SP1 CBX8 POLR2A CTBP2 TLX2 LBX2 WBP1 INO80B PCGF1 ALMS1P1 MRPL53 CCDC142 ENSG00000159239 DQX1
GH02I074438 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.2 -17.3 -17273 4.2 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RTKN ENSG00000272183 SLC4A5 WBP1 ALMS1P1 GC02M074442 GC02M074444 GC02M074419
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WBP1 gene promoter:

Genomic Locations for WBP1 Gene

Genomic Locations for WBP1 Gene
2,563 bases
Plus strand

Genomic View for WBP1 Gene

Genes around WBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP1 Gene

Proteins for WBP1 Gene

  • Protein details for WBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WW domain-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RE02
    • O95637

    Protein attributes for WBP1 Gene

    269 amino acids
    Molecular mass:
    29140 Da
    Quaternary structure:
    • Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX.
    • Sequence=AAD10950.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WBP1 Gene

neXtProt entry for WBP1 Gene

Post-translational modifications for WBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WBP1 Gene

No data available for DME Specific Peptides for WBP1 Gene

Domains & Families for WBP1 Gene

Gene Families for WBP1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for WBP1 Gene


Suggested Antigen Peptide Sequences for WBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The PPxY motif 2 mediates interaction with WWOX. Both PPxY motifs mediate interaction with NEDD4 (By similarity).
  • The PPxY motif 2 mediates interaction with WWOX. Both PPxY motifs mediate interaction with NEDD4 (By similarity).
genes like me logo Genes that share domains with WBP1: view

Function for WBP1 Gene

Molecular function for WBP1 Gene

GENATLAS Biochemistry:
WW domain binding protein 1,proline-rich ligand of YES-associated,putatively involved in protein-protein interaction

Gene Ontology (GO) - Molecular Function for WBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15064722
GO:0050699 WW domain binding IEA,ISS --
genes like me logo Genes that share ontologies with WBP1: view
genes like me logo Genes that share phenotypes with WBP1: view

Animal Model Products

CRISPR Products

miRNA for WBP1 Gene

miRTarBase miRNAs that target WBP1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WBP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP1 Gene

Localization for WBP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WBP1 gene
Compartment Confidence
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WBP1 Gene

Pathways & Interactions for WBP1 Gene

genes like me logo Genes that share pathways with WBP1: view

Pathways by source for WBP1 Gene

1 GeneGo (Thomson Reuters) pathway for WBP1 Gene

Gene Ontology (GO) - Biological Process for WBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with WBP1: view

No data available for SIGNOR curated interactions for WBP1 Gene

Drugs & Compounds for WBP1 Gene

No Compound Related Data Available

Transcripts for WBP1 Gene

Unigene Clusters for WBP1 Gene

WW domain binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WBP1

Alternative Splicing Database (ASD) splice patterns (SP) for WBP1 Gene

No ASD Table

Relevant External Links for WBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WBP1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of WBP1 Gene:


SOURCE GeneReport for Unigene cluster for WBP1 Gene:


mRNA Expression by UniProt/SwissProt for WBP1 Gene:

Tissue specificity: Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and kidney.

Evidence on tissue expression from TISSUES for WBP1 Gene

  • Eye(4.6)
  • Lung(4.6)
  • Nervous system(4.5)
  • Pancreas(4.4)
  • Skin(3.5)
  • Kidney(2.5)
  • Muscle(2.3)
  • Intestine(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with WBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for WBP1 Gene

Orthologs for WBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WBP1 33
  • 98.51 (n)
(Canis familiaris)
Mammalia WBP1 33 34
  • 89.14 (n)
(Bos Taurus)
Mammalia WBP1 33 34
  • 88.72 (n)
(Mus musculus)
Mammalia Wbp1 33 16 34
  • 87.73 (n)
(Rattus norvegicus)
Mammalia Wbp1 33
  • 87.24 (n)
(Monodelphis domestica)
Mammalia WBP1 34
  • 56 (a)
(Anolis carolinensis)
Reptilia WBP1 34
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5133 33
(Danio rerio)
Actinopterygii zgc:77391 33
  • 61.3 (n)
WBP1 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2554 34
  • 34 (a)
Species where no ortholog for WBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WBP1 Gene

Gene Tree for WBP1 (if available)
Gene Tree for WBP1 (if available)

Paralogs for WBP1 Gene

Paralogs for WBP1 Gene

(1) SIMAP similar genes for WBP1 Gene using alignment to 4 proteins: Pseudogenes for WBP1 Gene

genes like me logo Genes that share paralogs with WBP1: view

Variants for WBP1 Gene

Sequence variations from dbSNP and Humsavar for WBP1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs368859958 uncertain-significance, not specified, Congenital disorder of glycosylation 74,461,355(+) G/A/C downstream_transcript_variant
rs929416520 uncertain-significance, Congenital disorder of glycosylation 74,461,110(+) C/T downstream_transcript_variant
rs1000448439 -- 74,461,214(+) G/C downstream_transcript_variant
rs1001347317 -- 74,457,113(+) C/T upstream_transcript_variant
rs1001842485 -- 74,456,842(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WBP1 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for WBP1 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP1 Gene

Disorders for WBP1 Gene

Additional Disease Information for WBP1

No disorders were found for WBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP1 Gene

Publications for WBP1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PMID: 15064722) Ludes-Meyers JH … Aldaz CM (Oncogene 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PMID: 9169421) Pirozzi G … Fowlkes DM (The Journal of biological chemistry 1997) 3 4 58
  5. Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands. (PMID: 9202023) Chen HI … Sudol M (The Journal of biological chemistry 1997) 3 4 58

Products for WBP1 Gene

  • Addgene plasmids for WBP1

Sources for WBP1 Gene

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