Aliases for WASHC5 Gene
Aliases for WASHC5 Gene
External Ids for WASHC5 Gene
- HGNC: 28984
- Entrez Gene: 9897
- Ensembl: ENSG00000164961
- OMIM: 610657
- UniProtKB: Q12768
Previous HGNC Symbols for WASHC5 Gene
- SPG8
- KIAA0196
Previous GeneCards Identifiers for WASHC5 Gene
- GC08M125564
- GC08M125692
- GC08M125825
- GC08M126306
Summaries for WASHC5 Gene
-
This gene encodes a 134 kDa protein named strumpellin that is predicted to have multiple transmembrane domains and a spectrin-repeat-containing domain. This ubiquitously expressed gene has its highest expression in skeletal muscle. The protein is named for Strumpell disease; a form of hereditary spastic paraplegia (HSP). Spastic paraplegias are a diverse group of disorders in which the autosomal dominant forms are characterized by progressive, lower extremity spasticity caused by axonal degeneration in the terminal portions of the longest descending and ascending corticospinal tracts. More than 30 loci (SPG1-33) have been implicated in hereditary spastic paraplegia diseases. [provided by RefSeq, Aug 2009]
GeneCards Summary for WASHC5 Gene
WASHC5 (WASH Complex Subunit 5) is a Protein Coding gene. Diseases associated with WASHC5 include Spastic Paraplegia 8, Autosomal Dominant and Ritscher-Schinzel Syndrome 1. Among its related pathways are Endocytosis.
UniProtKB/Swiss-Prot for WASHC5 Gene
-
Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666).
Additional gene information for WASHC5 Gene
- Monarch Initiative
- Search for WASHC5 at DataMed
- Search for WASHC5 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WASHC5 Gene
Genomics for WASHC5 Gene
GeneHancer (GH) Regulatory Elements for WASHC5 Gene
Promoters and enhancers for WASHC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around WASHC5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for WASHC5 Gene
Genomic Locations for WASHC5 Gene
- chr8:125,024,260-125,091,840
- (GRCh38/hg38)
- Size:
- 67,581 bases
- Orientation:
- Minus strand
- chr8:126,036,502-126,104,082
- (GRCh37/hg19)
- Size:
- 67,581 bases
- Orientation:
- Minus strand
Genomic View for WASHC5 Gene
Genes around WASHC5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.13 by Entrez Gene
- 8q24.13 by HGNC
- 8q24.13 by Ensembl
WASHC5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WASHC5 Gene
Proteins for WASHC5 Gene
-
Protein details for WASHC5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12768-WASC5_HUMAN
- Recommended name:
- WASH complex subunit 5
- Protein Accession:
- Q12768
- A8K4R7
- Q3KQX5
- Q8TBQ2
Protein attributes for WASHC5 Gene
- Size:
- 1159 amino acids
- Molecular mass:
- 134286 Da
- Quaternary structure:
-
- Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. The WASH core complex associates via WASHC2 with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex. Interacts with VCP, PI4K2A.
- SequenceCaution:
-
- Sequence=BAA12109.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Post-translational modifications for WASHC5 Gene
Other Protein References for WASHC5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for WASHC5
-
Abcam antibodies for WASHC5
- Invitrogen Antibodies for WASHC5 (AFLGC-WASHC5)
- GeneTex WASHC5 Antibody for WASHC5
-
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-
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Protein Products
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- Search GeneTex for Proteins for WASHC5
Assay Products
- antibodies-online: Search results for 1 available KIAA0196 Elisa Kits ranked by validation data
- Compare Top KIAA0196 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for WASHC5 Gene
Domains & Families for WASHC5 Gene
Gene Families for WASHC5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for WASHC5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for WASHC5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q12768- Family:
-
- Belongs to the strumpellin family.
Function for WASHC5 Gene
Molecular function for WASHC5 Gene
- UniProtKB/Swiss-Prot Function:
- Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666).
Phenotypes From GWAS Catalog for WASHC5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 20923837 |
Phenotypes for WASHC5 Gene
- MGI mutant phenotypes for WASHC5:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for WASHC5:
Animal Models for WASHC5 Gene
- MGI Knock Outs for WASHC5:
-
- Washc5 Washc5<tm1a(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for WASHC5
-
CRISPR Products
-
OriGene CRISPR knockouts for WASHC5
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-
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-
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miRNA for WASHC5 Gene
- miRTarBase miRNAs that target WASHC5
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for WASHC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WASHC5
- genomics-online: cdna clones - Search results for available KIAA0196 gene related products
- orf clones - Search results for available KIAA0196 gene related products
- Applied Biological Materials Clones for WASHC5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WASHC5 Gene
Localization for WASHC5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WASHC5 Gene
- Cytoplasm, cytosol. Endoplasmic reticulum. Early endosome. Note=Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord. {ECO:0000269 PubMed:20833645}.
| Compartment | Confidence |
|---|---|
| endosome | 5 |
| endoplasmic reticulum | 3 |
| cytosol | 3 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | IDA,IEA | 23676666 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
Pathways & Interactions for WASHC5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Endocytosis | ||
Pathways by source for WASHC5 Gene
1 KEGG pathway for WASHC5 Gene
Interacting Proteins for WASHC5 Gene
Selected Interacting proteins:
ENSP00000318016
Q12768-WASC5_HUMAN
for WASHC5 Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for WASHC5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001556 | oocyte maturation | IEA | -- |
| GO:0010976 | positive regulation of neuron projection development | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0016197 | endosomal transport | IEA | -- |
| GO:0040038 | polar body extrusion after meiotic divisions | IEA | -- |
No data available for SIGNOR curated interactions for WASHC5 Gene
Transcripts for WASHC5 Gene
mRNA/cDNA for WASHC5 Gene
- (4) REFSEQ mRNAs :
- (242) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000519042 976 bps (uc064qbn.1)
- ENST00000318410 4187 bps (uc003yrt.4)
- ENST00000517845 3667 bps (uc011lir.3)
- ENST00000530856 364 bps (uc064qbp.1)
- ENST00000523297 859 bps (uc064qbq.1)
CRISPR Products
-
OriGene CRISPR knockouts for WASHC5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WASHC5
- genomics-online: gRNA clones - Search results for available KIAA0196 gene related products
- Applied Biological Materials CRISPR for WASHC5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for WASHC5
- GenScript: Design CRISPR guide RNA sequences for WASHC5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WASHC5
- Browse OriGene Inhibitory RNA Products For WASHC5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WASHC5
- genomics-online: shRNA clones - Search results for available KIAA0196 gene related products
Clone Products
- Sino Biological Human cDNA Clone for WASHC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WASHC5
- genomics-online: cdna clones - Search results for available KIAA0196 gene related products
- orf clones - Search results for available KIAA0196 gene related products
- Applied Biological Materials Clones for WASHC5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for WASHC5 Gene
NURSA nuclear receptor signaling pathways regulating expression of WASHC5 Gene:
WASHC5mRNA Expression by UniProt/SwissProt for WASHC5 Gene:
Q12768-WASC5_HUMAN
Tissue specificity:
Expressed ubiquitously.
Evidence on tissue expression from TISSUES for WASHC5 Gene
- Lung(4.3)
- Bone marrow(4.2)
- Nervous system(4)
- Adrenal gland(2.4)
- Kidney(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for WASHC5 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cerebrospinal fluid
- chin
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- mandible
- maxilla
- meninges
- mouth
- neck
- nose
- outer ear
- pituitary gland
- scalp
- skull
Thorax:
- aorta
- chest wall
- heart
- heart valve
- lung
- rib
- rib cage
Abdomen:
- adrenal gland
- intestine
- kidney
- large intestine
Pelvis:
- anus
- pelvis
- penis
- prostate
- rectum
- ureter
- urethra
- urinary bladder
- uterus
Limb:
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
General:
- blood
- blood vessel
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for WASHC5
-
OriGene qPCR primer pairs and template standards for WASHC5
- genomics-online: primer clones - Search results for available KIAA0196 gene related products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for WASHC5 Gene
Orthologs for WASHC5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KIAA0196 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | KIAA0196 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | KIAA0196 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | KIAA0196 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | RGD1564420 33 |
|
||
| mouse (Mus musculus) |
Mammalia | E430025E21Rik 34 33 |
|
OneToOne | |
| Washc5 16 |
|
||||
| chicken (Gallus gallus) |
Aves | KIAA0196 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KIAA0196 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kiaa0196 33 |
|
||
| Str.16493 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24528 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | strumpellin 34 33 |
|
OneToOne | |
| zgc55908 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007019 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG12272 34 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | T05E7.3 34 33 |
|
OneToOne | |
| rice (Oryza sativa) |
Liliopsida | Os04g0398800 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2068 34 |
|
OneToOne |
- Species where no ortholog for WASHC5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for WASHC5 Gene
- ENSEMBL:
- Gene Tree for WASHC5 (if available)
- TreeFam:
- Gene Tree for WASHC5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WASHC5: view image
Paralogs for WASHC5 Gene
No data available for Paralogs for WASHC5 Gene
Variants for WASHC5 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10429323 | likely-benign, benign, Spastic Paraplegia, Dominant, not specified, Dandy-Walker like malformation with atrioventricular septal defect, Spastic paraplegia 8 | 125,067,625(-) | T/C | coding_sequence_variant, synonymous_variant | |
| rs1060502725 | uncertain-significance, Spastic paraplegia, not specified | 125,055,602(-) | C/T | coding_sequence_variant, missense_variant | |
| rs1060504698 | likely-benign, Spastic paraplegia | 125,083,803(-) | G/A/C | coding_sequence_variant, intron_variant, synonymous_variant | |
| rs11542889 | conflicting-interpretations-of-pathogenicity, benign, not specified, Spastic Paraplegia, Dominant, Spastic paraplegia 8 | 125,032,285(-) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant | |
| rs138407503 | benign, likely-benign, Dandy-Walker like malformation with atrioventricular septal defect, Spastic paraplegia 8, not specified, Spastic Paraplegia, Dominant, not provided | 125,032,257(-) | C/A/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant |
Residual Variation Intolerance Score:
1.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.76;
33.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WASHC5 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WASHC5 Gene
Disorders for WASHC5 Gene
(14) MalaCards diseases for WASHC5 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spastic paraplegia 8, autosomal dominant |
|
|
| ritscher-schinzel syndrome 1 |
|
|
| spastic paraplegia 8 |
|
|
| spasticity |
|
|
| paraplegia |
|
|
Search WASHC5 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
WASC5_HUMAN- Spastic paraplegia 8, autosomal dominant (SPG8) [MIM:603563]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. {ECO:0000269 PubMed:17160902, ECO:0000269 PubMed:20833645, ECO:0000269 PubMed:23085491, ECO:0000269 PubMed:23455931, ECO:0000269 PubMed:23881105, ECO:0000269 PubMed:25454649}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Ritscher-Schinzel syndrome 1 (RTSC1) [MIM:220210]: A developmental malformation syndrome characterized by craniofacial abnormalities, congenital heart defects, and cerebellar brain malformations. Facial features include prominent occiput, prominent forehead, low-set ears, downslanting palpebral fissures, depressed nasal bridge, and micrognathia. Cardiac defects can include septal defects and aortic stenosis, among others, and brain imaging shows Dandy-Walker malformation, cerebellar vermis hypoplasia, posterior fossa cysts, and ventricular dilatation. Affected individuals have severe developmental delay. {ECO:0000269 PubMed:24065355}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for WASHC5
No data available for Genatlas for WASHC5 Gene
Publications for WASHC5 Gene
- The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function. (PMID: 23085491) Freeman C … Reid E (Biochimica et biophysica acta 2013) 2 3 4 58
- Mutations in the KIAA0196 gene at the SPG8 locus cause hereditary spastic paraplegia. (PMID: 17160902) Valdmanis PN … Rouleau GA (American journal of human genetics 2007) 2 3 4 58
- The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα. (PMID: 23676666) Ryder PV … Faundez V (Molecular biology of the cell 2013) 3 4 58
- A novel mutation in KIAA0196: identification of a gene involved in Ritscher-Schinzel/3C syndrome in a First Nations cohort. (PMID: 24065355) Elliott AM … Zelinski T (Journal of medical genetics 2013) 3 4 58
- Exome sequencing expands the mutational spectrum of SPG8 in a family with spasticity responsive to L-DOPA treatment. (PMID: 23881105) Bettencourt C … Houlden H (Journal of neurology 2013) 3 4 58
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- genomics-online: cdna clones - Search results for available KIAA0196 gene related products
- orf clones - Search results for available KIAA0196 gene related products
- genomics-online: gRNA clones - Search results for available KIAA0196 gene related products
- genomics-online: primer clones - Search results for available KIAA0196 gene related products
- genomics-online: shRNA clones - Search results for available KIAA0196 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WASHC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WASHC5
- GeneCopoeia miRNA 3'UTR Target clone products for WASHC5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WASHC5
Sources for WASHC5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt