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Aliases for WASHC2C Gene
Aliases for WASHC2C Gene
External Ids for WASHC2C Gene
- HGNC: 23414
- Entrez Gene: 253725
- Ensembl: ENSG00000172661
- OMIM: 613631
- UniProtKB: Q9Y4E1
Previous HGNC Symbols for WASHC2C Gene
- FAM21C
Summaries for WASHC2C Gene
GeneCards Summary for WASHC2C Gene
WASHC2C (WASH Complex Subunit 2C) is a Protein Coding gene. Diseases associated with WASHC2C include Vaccinia and Transient Tic Disorder. Among its related pathways are Endocytosis. An important paralog of this gene is WASHC2A.
UniProtKB/Swiss-Prot Summary for WASHC2C Gene
-
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission (PubMed:19922874, PubMed:20498093, PubMed:22513087, PubMed:23331060). Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35 (PubMed:24980502). Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L (PubMed:25355947, PubMed:28892079).
-
(Microbial infection) Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells.
Additional gene information for WASHC2C Gene
- HGNC(23414)
- Entrez Gene(253725)
- Ensembl(ENSG00000172661)
- OMIM(613631)
- UniProtKB(Q9Y4E1)
- Open Targets Platform(ENSG00000172661)
- Search for WASHC2C at DataMed
- Search for WASHC2C at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WASHC2C Gene
Genomics for WASHC2C Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for WASHC2C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around WASHC2C on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WASHC2C
Genomic Locations for WASHC2C Gene
Genomic Locations for WASHC2C Gene
- chr10:45,727,043-45,792,964
- (GRCh38/hg38)
- Size:
- 65,922 bases
- Orientation:
- Plus strand
- chr10:46,222,648-46,288,412
- (GRCh37/hg19)
- Size:
- 65,765 bases
- Orientation:
- Plus strand
Genomic View for WASHC2C Gene
Genes around WASHC2C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q11.22 by HGNC
- 10q11.22 by Entrez Gene
- 10q11.22 by Ensembl
WASHC2C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WASHC2C Gene
Proteins for WASHC2C Gene
-
Protein details for WASHC2C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y4E1-WAC2C_HUMAN
- Recommended name:
- WASH complex subunit 2C
- Protein Accession:
- Q9Y4E1
- B4DZQ6
- B9EK53
- F5H0J6
- F5H871
- Q5SQU4
- Q5SQU5
- Q7L521
- Q9UG79
Protein attributes for WASHC2C Gene
- Size:
- 1320 amino acids
- Molecular mass:
- 144911 Da
- Quaternary structure:
-
- Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5; in the complex interacts (via N-terminus) directly with WASHC1. The WASH core complex associates via WASHC2 with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex (PubMed:19922875, PubMed:20498093). Interacts with VPS35; mediates the association with the retromer CSC complex. Interacts with FKBP15. Interacts with CCDC93, CCDC22, VPS35L; indicative for an association of the WASH core complex with the CCC and retriever complexes. May directly interact with TBC1D23 (Probable).
- SequenceCaution:
-
- Sequence=AAH06456.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA25518.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- In human, WASHC2 has undergone evolutionary duplication, with 4 highly homologous family members existing, including WASHC2A, WASHC2C, and an N-terminally truncated WASHC2D form.
Post-translational modifications for WASHC2C Gene
Other Protein References for WASHC2C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_011537870.1
- XP_011537871.1
- XP_011537872.1
- XP_011537874.1
- XP_011537875.1
- XP_016871503.1
- XP_016871506.1
- XP_016871514.1
- NP_001162577.1
- NP_001162578.1
- NP_001317003.1
- NP_001354322.1
- NP_001354323.1
- NP_001354324.1
- NP_001354325.1
- NP_001354326.1
- NP_001354327.1
- NP_001354328.1
- NP_001354329.1
- NP_001354330.1
- NP_001354331.1
- NP_001354332.1
- NP_001354333.1
- NP_001354334.1
- NP_001354335.1
- NP_001354336.1
- NP_001354337.1
- NP_001354338.1
- NP_001354339.1
- NP_001354340.1
- NP_001354341.1
- NP_001354342.1
- NP_001354343.1
- NP_001354344.1
- NP_001354345.1
- NP_056077.2
Antibody Products
- Creative Diagnostics Anti-FAM21C monoclonal antibody
- Creative Biolabs Recombinant Anti-Human FAM21C Antibody
- Novus Biologicals Antibodies for WASHC2C
- Invitrogen Antibodies for WASHC2C (AFLGC-WASHC2C)
Protein Products
-
OriGene Purified Proteins for WASHC2C
- Search Origene for MassSpec and Protein Over-expression Lysates for WASHC2C
- Origene Custom Protein Services for WASHC2C
- antibodies-online: Show 4 available FAM21C Proteins ranked by validation data
- Compare Top FAM21C Proteins
-
Quality Products:
-
Abcam proteins for WASHC2C
No data available for DME Specific Peptides for WASHC2C Gene
Domains & Families for WASHC2C Gene
Gene Families for WASHC2C Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for WASHC2C Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for WASHC2C Gene
- GenScript: Design optimal peptide antigens:
-
- FAM21C protein (B9EK53_HUMAN)
- Vaccinia virus penetration factor (FA21C_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y4E1UniProtKB/Swiss-Prot:
WAC2C_HUMAN :- The LFa (leucine-phenylalanine-acidic) motif bind directly to VPS35 of retromer CSC; adjacent motifs can act cooperatively to bind multiple CSCs, although there is significant variability in the affinities of different motifs for retromer.
- Belongs to the FAM21 family.
- Domain:
-
- The LFa (leucine-phenylalanine-acidic) motif bind directly to VPS35 of retromer CSC; adjacent motifs can act cooperatively to bind multiple CSCs, although there is significant variability in the affinities of different motifs for retromer.
- Family:
-
- Belongs to the FAM21 family.
Function for WASHC2C Gene
Molecular function for WASHC2C Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission (PubMed:19922874, PubMed:20498093, PubMed:22513087, PubMed:23331060). Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35 (PubMed:24980502). Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L (PubMed:25355947, PubMed:28892079).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells.
Phenotypes From GWAS Catalog for WASHC2C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19922874 |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IDA | 20498093 |
| GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | IDA | 20498093 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0010314 | phosphatidylinositol-5-phosphate binding | IDA | 20498093 |
Phenotypes for WASHC2C Gene
- MGI mutant phenotypes for WASHC2C:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for WASHC2C:
Animal Models for WASHC2C Gene
- MGI Knock Outs for WASHC2C:
-
- Washc2 Washc2<tm2b(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WASHC2C - Select products 50% OFF >
- * WASHC2C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WASHC2C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WASHC2C
miRNA for WASHC2C Gene
- miRTarBase miRNAs that target WASHC2C
-
- hsa-miR-598-3p (MIRT040482)
- hsa-miR-149-5p (MIRT045583)
- hsa-miR-27a-3p (MIRT050034)
- hsa-miR-145-5p (MIRT762720)
- hsa-miR-208a-3p (MIRT763739)
- hsa-miR-208b-3p (MIRT763746)
- hsa-miR-3667-5p (MIRT766565)
- hsa-miR-499a-5p (MIRT772887)
- hsa-miR-5195-3p (MIRT773631)
- hsa-miR-548ao-3p (MIRT774157)
- hsa-miR-591 (MIRT775363)
- hsa-miR-6502-3p (MIRT776556)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WASHC2C
- Browse OriGene Inhibitory RNA Products For WASHC2C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WASHC2C
Clone Products
- Applied Biological Materials (abm): Clones for WASHC2C - Select products 50% OFF >
- * WASHC2C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for WASHC2C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WASHC2C
Cell Line Products
-
Horizon Cell Lines for WASHC2C
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WASHC2C Gene
Localization for WASHC2C Gene
Subcellular locations from UniProtKB/Swiss-Prot for WASHC2C Gene
- Early endosome membrane. Cell membrane. Note=Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| nucleus | 4 |
| cytosol | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Vesicles (3)
- Nucleoli (2)
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005768 | endosome | IDA | 20923837 |
| GO:0005769 | early endosome | IDA | 19922874 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
Pathways & Interactions for WASHC2C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Endocytosis | ||
Pathways by source for WASHC2C Gene
1 KEGG pathway for WASHC2C Gene
Interacting Proteins for WASHC2C Gene
GPS-Prot Interaction Network for WASHC2C
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015031 | protein transport | IEA | -- |
| GO:0036010 | protein localization to endosome | IMP | 28892079 |
| GO:0042147 | retrograde transport, endosome to Golgi | IMP | 19922874 |
| GO:1900024 | regulation of substrate adhesion-dependent cell spreading | IDA | 22070227 |
| GO:1990126 | retrograde transport, endosome to plasma membrane | IMP | 25278552 |
No data available for SIGNOR curated interactions for WASHC2C Gene
Transcripts for WASHC2C Gene
mRNA/cDNA for WASHC2C Gene
- 28 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000336378 4669 nts (view in UCSC)
- ENST00000359860 4471 nts (view in UCSC)
- ENST00000374359 785 nts (view in UCSC)
- ENST00000374362 4623 nts (view in UCSC)
- ENST00000420848 868 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WASHC2C - Select products 50% OFF >
- * WASHC2C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WASHC2C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WASHC2C
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WASHC2C
- Browse OriGene Inhibitory RNA Products For WASHC2C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WASHC2C
Clone Products
- Applied Biological Materials (abm): Clones for WASHC2C - Select products 50% OFF >
- * WASHC2C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for WASHC2C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WASHC2C
Relevant External Links for WASHC2C Gene
- GeneLoc Exon Structure for
- WASHC2C
Expression for WASHC2C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WASHC2C
Evidence on tissue expression from TISSUES for WASHC2C Gene
- Nervous system(4.2)
- Kidney(4.1)
- Lung(4.1)
- Liver(4)
Primer Products
-
OriGene qPCR primer pairs for WASHC2C
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WASHC2C Gene
Orthologs for WASHC2C Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC738985 30 |
|
||
| FAM21C 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | LOC477751 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | FAM21A 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Fam21 30 31 |
|
OneToMany | |
| Washc2 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Fam21c 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | FAM21A 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fam21a 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fam21c 30 31 |
|
OneToMany |
- Species where no ortholog for WASHC2C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for WASHC2C Gene
- ENSEMBL:
- Gene Tree for WASHC2C (if available)
- TreeFam:
- Gene Tree for WASHC2C (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WASHC2C: view image
Paralogs for WASHC2C Gene
Variants for WASHC2C Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv114e214 | CNV | gain | 21293372 |
| esv23760 | CNV | gain+loss | 19812545 |
| esv2852680 | CNV | deletion | 24192839 |
| esv33964 | CNV | loss | 17666407 |
| nsv1076365 | CNV | duplication | 25765185 |
| nsv1118164 | CNV | deletion | 24896259 |
| nsv499498 | OTHER | inversion | 21111241 |
| nsv7202 | OTHER | inversion | 18451855 |
| nsv947914 | CNV | duplication | 23825009 |
| nsv947915 | CNV | duplication | 23825009 |
| nsv947916 | CNV | duplication | 23825009 |
| nsv947917 | CNV | duplication | 23825009 |
Gene Damage Index Score:
8.49;
85.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WASHC2C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- WASHC2C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WASHC2C Gene
Disorders for WASHC2C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vaccinia |
|
|
| transient tic disorder |
|
|
Search WASHC2C in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for WASHC2C
No data available for UniProtKB/Swiss-Prot and Genatlas for WASHC2C Gene
Publications for WASHC2C Gene
- WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. (PMID: 20498093) Jia D … Billadeau DD (Proceedings of the National Academy of Sciences of the United States of America 2010) 2 3 4
- Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. (PMID: 28892079) McNally KE … Cullen PJ (Nature cell biology 2017) 3 4
- COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4
- Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. (PMID: 25278552) McGough IJ … Cullen PJ (Journal of cell science 2014) 3 4
- Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer. (PMID: 23331060) Helfer E … Gautreau A (Biology of the cell 2013) 3 4
ExternalLinks
Products for WASHC2C Gene
- Browse OriGene Antibodies
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- Custom Assay Services
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- OriGene qPCR primer pairs for WASHC2C
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- High-throughput Antibody Production Service
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- Novus Biologicals Antibodies for WASHC2C
- Novus Biologicals proteins and lysates for WASHC2C
- Browse Antibodies
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- Abcam proteins for WASHC2C
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
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- Invitrogen Antibodies for WASHC2C (AFLGC-WASHC2C)
- VectorBuilder Custom and pre-made DNA vectors for WASHC2C (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 20 available FAM21C Antibodies ranked by validation data
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- antibodies-online: Show 4 available FAM21C Proteins ranked by validation data
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- Horizon Cell Lines for WASHC2C
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WASHC2C
Sources for WASHC2C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB