Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WASH4P Gene

Aliases for WASH4P Gene

  • WAS Protein Family Homolog 4 Pseudogene 2 3 5
  • Family With Sequence Similarity 39, Member C Pseudogene 2 3
  • FAM39CP 3 4
  • Putative WAS Protein Family Homolog 4 3
  • Pseudogene Of CXYorf1 3
  • Protein FAM39CP 4
  • CXYorf1P 3

External Ids for WASH4P Gene

Previous HGNC Symbols for WASH4P Gene

  • FAM39CP

Previous GeneCards Identifiers for WASH4P Gene

  • GC16M000008
  • GC16M000064

Summaries for WASH4P Gene

GeneCards Summary for WASH4P Gene

WASH4P (WAS Protein Family Homolog 4 Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include actin binding and alpha-tubulin binding.

UniProtKB/Swiss-Prot for WASH4P Gene

  • May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

Additional gene information for WASH4P Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WASH4P Gene

Genomics for WASH4P Gene

GeneHancer (GH) Regulatory Elements for WASH4P Gene

Promoters and enhancers for WASH4P Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I000396 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.2 -381.8 -381792 7.7 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 NME4 DECR2 WDR90 ENSG00000261505 RHOT2 WASH4P JMJD8 CAPN15 UBE2I AXIN1
GH16I000586 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.5 -573.0 -573041 8.4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 RAB40C GC16M000587 WDR90 ENSG00000261505 ENSG00000260051 WFIKKN1 ENSG00000260954 RHOT2 WASH4P JMJD8
GH16I000233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.5 -216.9 -216858 2.9 HDGF PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B FAM234A WDR90 LUC7L RHOT2 ENSG00000268836 JMJD8 WASH4P ENSG00000228779 WDR24 LMF1
GH16I000180 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 34.2 -163.0 -163008 1.9 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 ZNF207 ZNF143 KLF13 HBQ1 WDR90 RHOT2 WASH4P WDR24 JMJD8 ENSG00000268836 ENSG00000260022 AXIN1 LMF1
GH16I000689 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 26.7 -672.2 -672151 1.7 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 POLR2B WDR24 ENSG00000261659 TELO2 ENSG00000261505 LUC7L WDR90 CRAMP1 ENSG00000260051 IFT140 ENSG00000268836
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WASH4P on UCSC Golden Path with GeneCards custom track

Genomic Locations for WASH4P Gene

Genomic Locations for WASH4P Gene
4,013 bases
Minus strand

Genomic View for WASH4P Gene

Genes around WASH4P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WASH4P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WASH4P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WASH4P Gene

Proteins for WASH4P Gene

  • Protein details for WASH4P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative WAS protein family homolog 4
    Protein Accession:

    Protein attributes for WASH4P Gene

    477 amino acids
    Molecular mass:
    51595 Da
    Quaternary structure:
    • Interacts (via WHD1 region) with WASHC2C; the interaction is direct (By similarity).
    • WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene.

neXtProt entry for WASH4P Gene

Post-translational modifications for WASH4P Gene

No Post-translational modifications

No data available for DME Specific Peptides for WASH4P Gene

Domains & Families for WASH4P Gene

Gene Families for WASH4P Gene

Protein Domains for WASH4P Gene


Suggested Antigen Peptide Sequences for WASH4P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WASH1 family.
  • Belongs to the WASH1 family.
genes like me logo Genes that share domains with WASH4P: view

Function for WASH4P Gene

Molecular function for WASH4P Gene

UniProtKB/Swiss-Prot Function:
May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

Phenotypes From GWAS Catalog for WASH4P Gene

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WASH4P Gene

Localization for WASH4P Gene

Subcellular locations from UniProtKB/Swiss-Prot for WASH4P Gene

Early endosome membrane. Recycling endosome membrane. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2. {ECO:0000250 UniProtKB:A8K0Z3}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WASH4P gene
Compartment Confidence
endosome 4
cytosol 3
mitochondrion 2
nucleus 1

No data available for Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for WASH4P Gene

Pathways & Interactions for WASH4P Gene

SuperPathways for WASH4P Gene

No Data Available

Interacting Proteins for WASH4P Gene

Gene Ontology (GO) - Biological Process for WASH4P Gene


No data available for Pathways by source and SIGNOR curated interactions for WASH4P Gene

Drugs & Compounds for WASH4P Gene

No Compound Related Data Available

Transcripts for WASH4P Gene

mRNA/cDNA for WASH4P Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WASH4P Gene

No ASD Table

Relevant External Links for WASH4P Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WASH4P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WASH4P Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WASH4P Gene

Protein tissue co-expression partners for WASH4P Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WASH4P Gene:

genes like me logo Genes that share expression patterns with WASH4P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WASH4P Gene

Orthologs for WASH4P Gene

This gene was present in the common ancestor of animals.

Orthologs for WASH4P Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WASH4P 34
  • 96 (a)
(Canis familiaris)
Mammalia WASH4P 34
  • 80 (a)
(Bos Taurus)
Mammalia WASH1 34
  • 79 (a)
(Monodelphis domestica)
Mammalia WASH4P 34
  • 75 (a)
(Mus musculus)
Mammalia Wash 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia WASH4P 34
  • 67 (a)
(Gallus gallus)
Aves WASH1 34
  • 69 (a)
(Anolis carolinensis)
Reptilia WASH4P 34
  • 66 (a)
(Danio rerio)
Actinopterygii wash 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta wash 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2847 34
  • 43 (a)
Species where no ortholog for WASH4P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WASH4P Gene

Gene Tree for WASH4P (if available)
Gene Tree for WASH4P (if available)

Paralogs for WASH4P Gene

(8) SIMAP similar genes for WASH4P Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WASH4P: view

No data available for Paralogs for WASH4P Gene

Variants for WASH4P Gene

Variation tolerance for WASH4P Gene

Gene Damage Index Score: 14.01; 96.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WASH4P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for WASH4P Gene

Disorders for WASH4P Gene

No disorders were found for WASH4P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for WASH4P Gene

Publications for WASH4P Gene

  1. Human subtelomeric WASH genes encode a new subclass of the WASP family. (PMID: 18159949) Linardopoulou EV … Trask BJ (PLoS genetics 2007) 2 3 4 58
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  3. Characterization of the murine orthologue of a novel human subtelomeric multigene family. (PMID: 11701968) Gianfrancesco F … D'Urso M (Cytogenetics and cell genetics 2001) 2 3 58
  4. The relationship between chromosome structure and function at a human telomeric region. (PMID: 9054936) Flint J … Higgs DR (Nature genetics 1997) 2 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for WASH4P Gene

Sources for WASH4P Gene

Loading form....