Aliases for WASF3 Gene
External Ids for WASF3 Gene
Previous GeneCards Identifiers for WASF3 Gene
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]
GeneCards Summary for WASF3 Gene
WASF3 (WASP Family Member 3) is a Protein Coding gene. Diseases associated with WASF3 include Wiskott-Aldrich Syndrome and Ganglioneuroblastoma. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is WASF1.
UniProtKB/Swiss-Prot Summary for WASF3 Gene
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.