Aliases for WASF2 Gene
External Ids for WASF2 Gene
Previous GeneCards Identifiers for WASF2 Gene
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for WASF2 Gene
WASF2 (WASP Family Member 2) is a Protein Coding gene. Diseases associated with WASF2 include Wiskott-Aldrich Syndrome and Spinocerebellar Ataxia, Autosomal Recessive 3. Among its related pathways are Adherens junction and RET signaling. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is WASF1.
UniProtKB/Swiss-Prot Summary for WASF2 Gene
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.