The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndro... See more...

Aliases for WASF1 Gene

Aliases for WASF1 Gene

  • WASP Family Member 1 2 3 5
  • SCAR1 2 3 4
  • WAVE1 2 3 4
  • Wiskott-Aldrich Syndrome Protein Family Member 1 3 4
  • Verprolin Homology Domain-Containing Protein 1 3 4
  • WASP Family Protein Member 1 3 4
  • WAS Protein Family Member 1 2 3
  • Protein WAVE-1 3 4
  • KIAA0269 2 4
  • WAVE 2 3
  • Homology Of Dictyostelium Scar 1 3
  • WAS Protein Family, Member 1 2
  • NEDALVS 3
  • WASF1 5

External Ids for WASF1 Gene

Previous GeneCards Identifiers for WASF1 Gene

  • GC06M110256
  • GC06M110443
  • GC06M110466
  • GC06M110527
  • GC06M107987
  • GC06M110421

Summaries for WASF1 Gene

Entrez Gene Summary for WASF1 Gene

  • The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WASF1 Gene

WASF1 (WASP Family Member 1) is a Protein Coding gene. Diseases associated with WASF1 include Neurodevelopmental Disorder With Absent Language And Variable Seizures and Alacrima, Achalasia, And Mental Retardation Syndrome. Among its related pathways are Signal transduction_PKA signaling and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include actin binding and Rac GTPase binding. An important paralog of this gene is WASF2.

UniProtKB/Swiss-Prot Summary for WASF1 Gene

  • Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568).

Gene Wiki entry for WASF1 Gene

Additional gene information for WASF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WASF1 Gene

Genomics for WASF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WASF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J110178 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 619.1 -0.1 -88 5 CEBPG SP1 HNRNPL GATAD2A CTCF PRDM10 ZNF629 ZNF512 SIX5 LEF1 WASF1 CDC40 ZBTB24 CD164 SMPD2 CNN2P9 FIG4
GH06J110203 Enhancer 0.5 Ensembl 28.8 -23.1 -23097 5 SCRT2 ZXDB POLR2A TAL1 DPF2 ZBTB33 SMARCA4 CBFA2T3 WASF1 CDC40 lnc-WASF1-1 lnc-GPR6-1 METTL24
GH06J110285 Enhancer 0.7 FANTOM5 Ensembl 21.1 -105.5 -105504 1.4 POLR2A ESR1 NFE2 KLF9 RCOR1 WASF1 CDC40 DDO piR-48222-317 LOC102724586 METTL24
GH06J110232 Enhancer 0.5 Ensembl 23.5 -53.4 -53397 2.4 ATF7 PRDM1 MEF2D CREB1 ATF2 IRF2 BATF TBX21 JUND WASF1 CDC40 lnc-GPR6-1 LOC105377937 METTL24
GH06J110094 Enhancer 1 FANTOM5 Ensembl ENCODE 10.8 +82.8 82803 6.8 PRDM10 CEBPB RCOR1 MAX NR2F2 EP300 STAT3 BHLHE40 ZNF366 HNF4A WASF1 GPR6 DDO lnc-CDC40-3 piR-51174
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WASF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WASF1

Top Transcription factor binding sites by QIAGEN in the WASF1 gene promoter:
  • AML1a
  • AREB6
  • Egr-4
  • Evi-1
  • FOXI1
  • FOXO1
  • FOXO1a
  • HFH-3
  • Nkx2-5
  • S8

Genomic Locations for WASF1 Gene

Genomic Locations for WASF1 Gene
chr6:110,099,819-110,180,004
(GRCh38/hg38)
Size:
80,186 bases
Orientation:
Minus strand
chr6:110,421,022-110,501,207
(GRCh37/hg19)
Size:
80,186 bases
Orientation:
Minus strand

Genomic View for WASF1 Gene

Genes around WASF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WASF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WASF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WASF1 Gene

Proteins for WASF1 Gene

  • Protein details for WASF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92558-WASF1_HUMAN
    Recommended name:
    Wiskott-Aldrich syndrome protein family member 1
    Protein Accession:
    Q92558
    Secondary Accessions:
    • E1P5F2
    • Q5SZK7

    Protein attributes for WASF1 Gene

    Size:
    559 amino acids
    Molecular mass:
    61652 Da
    Quaternary structure:
    • Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex. Interacts with ABI1 (via N-terminus). Interacts with SORBS2; this interaction greatly enhances phosphorylation by ABL1 and dephosphorylation by PTPN12 and might mediate partial to focal adhesion sites.
    SequenceCaution:
    • Sequence=BAA13399.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WASF1 Gene

neXtProt entry for WASF1 Gene

Post-translational modifications for WASF1 Gene

  • Phosphorylated on tyrosine residues by ABL1 and dephosphorylated by PTPN12.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WASF1 Gene

Domains & Families for WASF1 Gene

Gene Families for WASF1 Gene

Protein Domains for WASF1 Gene

InterPro:
Blocks:
  • Actin-binding WH2
ProtoNet:

Suggested Antigen Peptide Sequences for WASF1 Gene

GenScript: Design optimal peptide antigens:
  • WAS protein family, member 1 (Q5SZK3_HUMAN)
  • WAS protein family, member 1 (Q5SZK4_HUMAN)
  • WAS protein family, member 1 (Q5SZK5_HUMAN)
  • Verprolin homology domain-containing protein 1 (WASF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92558

UniProtKB/Swiss-Prot:

WASF1_HUMAN :
  • Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
  • Belongs to the SCAR/WAVE family.
Domain:
  • Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
Family:
  • Belongs to the SCAR/WAVE family.
genes like me logo Genes that share domains with WASF1: view

Function for WASF1 Gene

Molecular function for WASF1 Gene

UniProtKB/Swiss-Prot Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568).
GENATLAS Biochemistry:
WAS protein family,member1,widely expressed,strongly in brain,associating with the Arp2/3 complex a nucleating core for actin polymerization in vitro,potentially involved in the regulation of RAC induced of actin cytoskeleton required for membrane ruffling

Phenotypes From GWAS Catalog for WASF1 Gene

Gene Ontology (GO) - Molecular Function for WASF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 9843499
GO:0034237 protein kinase A regulatory subunit binding IBA 21873635
GO:0048365 contributes_to Rac GTPase binding IMP 21107423
GO:0051018 protein kinase A binding IPI 25097019
genes like me logo Genes that share ontologies with WASF1: view
genes like me logo Genes that share phenotypes with WASF1: view

Animal Models for WASF1 Gene

MGI Knock Outs for WASF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for WASF1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WASF1

Clone Products

  • Addgene plasmids for WASF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WASF1 Gene

Localization for WASF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WASF1 Gene

Cytoplasm, cytoskeleton. Cell junction, synapse. Cell junction, focal adhesion. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097). Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503). In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity). {ECO:0000250 UniProtKB:Q8R5H6, ECO:0000269 PubMed:18559503, ECO:0000269 PubMed:9889097}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WASF1 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
mitochondrion 3
cytosol 3
plasma membrane 2
extracellular 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WASF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005856 cytoskeleton TAS 10970852
GO:0005925 focal adhesion IEA --
genes like me logo Genes that share ontologies with WASF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WASF1 Gene

Pathways & Interactions for WASF1 Gene

genes like me logo Genes that share pathways with WASF1: view

Pathways by source for WASF1 Gene

3 GeneGo (Thomson Reuters) pathways for WASF1 Gene
  • Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
  • G-protein signaling RAC1 in cellular process
  • Signal transduction_PKA signaling
9 Qiagen pathways for WASF1 Gene
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Epithelial Adherens Junctions
  • Internalin Pathway
  • Rac1 Pathway

SIGNOR curated interactions for WASF1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for WASF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA,ISS --
GO:0016601 Rac protein signal transduction IMP 21107423
GO:0030036 actin cytoskeleton organization IEA,IMP 29961568
GO:0030041 actin filament polymerization TAS 9843499
GO:0031175 neuron projection development IEA --
genes like me logo Genes that share ontologies with WASF1: view

Drugs & Compounds for WASF1 Gene

No Compound Related Data Available

Transcripts for WASF1 Gene

mRNA/cDNA for WASF1 Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WASF1

Clone Products

  • Addgene plasmids for WASF1

Alternative Splicing Database (ASD) splice patterns (SP) for WASF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for WASF1 Gene

GeneLoc Exon Structure for
WASF1

Expression for WASF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WASF1 Gene

mRNA differential expression in normal tissues according to GTEx for WASF1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.0), Brain - Hippocampus (x4.4), Brain - Anterior cingulate cortex (BA24) (x4.4), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for WASF1 Gene

This gene is overexpressed in Frontal cortex (30.6), Fetal Brain (22.2), and Brain (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WASF1 Gene



Protein tissue co-expression partners for WASF1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WASF1

SOURCE GeneReport for Unigene cluster for WASF1 Gene:

Hs.75850

mRNA Expression by UniProt/SwissProt for WASF1 Gene:

Q92558-WASF1_HUMAN
Tissue specificity: Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.

Evidence on tissue expression from TISSUES for WASF1 Gene

  • Nervous system(4.9)
  • Bone marrow(4.2)
  • Skin(3.4)
  • Blood(2.6)
  • Heart(2.5)
  • Adrenal gland(2.2)
  • Muscle(2.1)
  • Stomach(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with WASF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for WASF1 Gene

Orthologs for WASF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for WASF1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WASF1 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WASF1 30 31
  • 96.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WASF1 30 31
  • 96.06 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Wasf1 30 17 31
  • 91 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WASF1 31
  • 91 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WASF1 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wasf1 30
  • 88.85 (n)
Chicken
(Gallus gallus)
Aves WASF1 30 31
  • 82.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WASF1 31
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wasf1 30
  • 76.38 (n)
Str.11165 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24126 30
Zebrafish
(Danio rerio)
Actinopterygii WASF1 31
  • 87 (a)
OneToOne
si:dkeyp-88f5.5 30
  • 72.9 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta SCAR 31 32
  • 28 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea wve-1 31
  • 31 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2335 31
  • 38 (a)
OneToMany
Species where no ortholog for WASF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WASF1 Gene

ENSEMBL:
Gene Tree for WASF1 (if available)
TreeFam:
Gene Tree for WASF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WASF1: view image

Paralogs for WASF1 Gene

Paralogs for WASF1 Gene

(2) SIMAP similar genes for WASF1 Gene using alignment to 4 proteins:

  • WASF1_HUMAN
  • Q5SZK3_HUMAN
  • Q5SZK4_HUMAN
  • Q5SZK5_HUMAN

Pseudogenes.org Pseudogenes for WASF1 Gene

genes like me logo Genes that share paralogs with WASF1: view

Variants for WASF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WASF1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
734709 Likely Benign: not provided 110,107,146(-) G/A SYNONYMOUS_VARIANT
743031 Likely Benign: not provided 110,103,560(-) A/G INTRON_VARIANT
801360 Likely Pathogenic: Intellectual disability 110,113,458(-) T/A NONSENSE
rs1562159088 Pathogenic: Intellectual disability; Epileptic encephalopathy; NEURODEVELOPMENTAL DISORDER WITH ABSENT LANGUAGE AND VARIABLE SEIZURES 110,100,644(-) G/A NONSENSE
rs1562159562 Pathogenic: Intellectual disability; NEURODEVELOPMENTAL DISORDER WITH ABSENT LANGUAGE AND VARIABLE SEIZURES 110,101,594(-) G/A NONSENSE

Additional dbSNP identifiers (rs#s) for WASF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for WASF1 Gene

Variant ID Type Subtype PubMed ID
esv2676234 CNV deletion 23128226
esv2732567 CNV deletion 23290073
esv2759462 CNV loss 17122850
esv3303474 CNV mobile element insertion 20981092
esv33528 CNV loss 17666407
esv3445217 CNV insertion 20981092
esv3540305 CNV deletion 23714750
esv3610349 CNV loss 21293372
nsv348708 CNV deletion 16902084
nsv436521 CNV deletion 17901297
nsv476214 CNV novel sequence insertion 20440878

Variation tolerance for WASF1 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WASF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WASF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WASF1 Gene

Disorders for WASF1 Gene

MalaCards: The human disease database

(38) MalaCards diseases for WASF1 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

UniProtKB/Swiss-Prot

WASF1_HUMAN
  • Neurodevelopmental disorder with absent language and variable seizures (NEDALVS) [MIM:618707]: A disorder characterized by neurodevelopmental abnormalities, including moderate to profound intellectual disability, with autistic features, seizures, severe impairments in speech, and gross motor delay. {ECO:0000269 PubMed:29961568}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for WASF1

genes like me logo Genes that share disorders with WASF1: view

No data available for Genatlas for WASF1 Gene

Publications for WASF1 Gene

  1. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. (PMID: 9889097) Machesky LM … Insall RH (Current biology : CB 1998) 2 3 4 23
  2. WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. (PMID: 9843499) Miki H … Takenawa T (The EMBO journal 1998) 2 3 23
  3. De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures. (PMID: 29961568) Ito Y … Raymond FL (American journal of human genetics 2018) 3 4
  4. Structure and control of the actin regulatory WAVE complex. (PMID: 21107423) Chen Z … Rosen MK (Nature 2010) 3 4
  5. [Interaction of WAVE1 and genes involved in multiple drug resistance in children with acute myeloblastic leukemia]. (PMID: 20426950) Yang MH … Cao LZ (Zhonghua er ke za zhi = Chinese journal of pediatrics 2010) 3 23

Products for WASF1 Gene

Sources for WASF1 Gene