Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitoc... See more...

Aliases for WARS2 Gene

Aliases for WARS2 Gene

  • Tryptophanyl TRNA Synthetase 2, Mitochondrial 2 3 5
  • Tryptophan TRNA Ligase 2, Mitochondrial 2 3
  • Tryptophan--TRNA Ligase, Mitochondrial 3 4
  • EC 6.1.1.2 4 50
  • (Mt)TrpRS 3 4
  • MtTrpRS 2 3
  • TrpRS 3 4
  • Tryptophanyl-TRNA Synthetase 4
  • EC 6.1.1 50
  • NEMMLAS 3
  • WARS2 5

External Ids for WARS2 Gene

Previous GeneCards Identifiers for WARS2 Gene

  • GC01M120022
  • GC01M118413
  • GC01M118720
  • GC01M118920
  • GC01M119286
  • GC01M119573
  • GC01M117432

Summaries for WARS2 Gene

Entrez Gene Summary for WARS2 Gene

  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for WARS2 Gene

WARS2 (Tryptophanyl TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with WARS2 include Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures and Lactic Acidosis. Among its related pathways are tRNA Aminoacylation and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleotide binding and tryptophan-tRNA ligase activity. An important paralog of this gene is WARS1.

UniProtKB/Swiss-Prot Summary for WARS2 Gene

  • Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.

Gene Wiki entry for WARS2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WARS2 Gene

Genomics for WARS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WARS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J119138 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 260.4 +0.2 210 3.2 BCLAF1 ZNF207 MYC IKZF1 ZNF600 JUND ZNF580 ZNF592 ATF2 POLR2A WARS2-AS1 WARS2 HSALNG0006467 lnc-TBX15-5 TBX15
GH01J119000 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 24.7 +139.3 139255 2.5 CEBPB MCM3 JUND PRDM10 CBX8 ARID1B ATF3 FOS RAD51 IKZF1 ENSG00000239216 LOC105378933 LOC107985191 TBX15 WARS2
GH01J119008 Enhancer 0.8 ENCODE dbSUPER 36.5 +131.9 131942 1.5 ZNF654 REST TRIM22 CTCF RAD21 SMC3 ZNF384 ZNF143 ZNF366 MBD1 HSALNG0006458 WARS2 WARS2-AS1 lnc-WARS2-3 TBX15
GH01J118981 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.2 +154.5 154541 9 CBX8 ZBTB33 NRF1 L3MBTL2 RAD21 EZH2 ZNF512 POLR2A KDM1A SP1 TBX15 WARS2 LOC105378933 WARS2-AS1 HSALNG0006456 SPAG17
GH01J119046 Promoter/Enhancer 0.8 EPDnew Ensembl ENCODE 33.9 +93.6 93587 1.6 MEIS2 WARS2-IT1 WARS2 lnc-TBX15-2 TBX15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WARS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WARS2

Top Transcription factor binding sites by QIAGEN in the WARS2 gene promoter:
  • aMEF-2
  • AML1a
  • LCR-F1
  • MEF-2
  • MEF-2A
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • POU3F2

Genomic Locations for WARS2 Gene

Latest Assembly
chr1:119,031,216-119,140,788
(GRCh38/hg38)
Size:
109,573 bases
Orientation:
Minus strand

Previous Assembly
chr1:119,573,839-119,683,295
(GRCh37/hg19 by Entrez Gene)
Size:
109,457 bases
Orientation:
Minus strand

chr1:119,573,839-119,683,294
(GRCh37/hg19 by Ensembl)
Size:
109,456 bases
Orientation:
Minus strand

Genomic View for WARS2 Gene

Genes around WARS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WARS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WARS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WARS2 Gene

Proteins for WARS2 Gene

  • Protein details for WARS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGM6-SYWM_HUMAN
    Recommended name:
    Tryptophan--tRNA ligase, mitochondrial
    Protein Accession:
    Q9UGM6
    Secondary Accessions:
    • B1ALR1
    • B2R9D4
    • Q53FT4
    • Q5VUD2
    • Q86TQ0

    Protein attributes for WARS2 Gene

    Size:
    360 amino acids
    Molecular mass:
    40147 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for WARS2 Gene

    Alternative splice isoforms for WARS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WARS2 Gene

Selected DME Specific Peptides for WARS2 Gene

Q9UGM6:
  • AADILLY
  • LGNYLGA
  • KMSKSDP
  • YPVLQAAD
  • VPVGEDQ

Post-translational modifications for WARS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for WARS2 Gene

Gene Families for WARS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for WARS2 Gene

Suggested Antigen Peptide Sequences for WARS2 Gene

GenScript: Design optimal peptide antigens:
  • Tryptophanyl tRNA synthetase 2, mitochondrial (B1ALR1_HUMAN)
  • cDNA FLJ50844, highly similar to Tryptophanyl-tRNA synthetase, mitochondrial (EC 6.1.1.2) (B7Z5X7_HUMAN)
  • Tryptophan--tRNA ligase (SYWM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UGM6

UniProtKB/Swiss-Prot:

SYWM_HUMAN :
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with WARS2: view

Function for WARS2 Gene

Molecular function for WARS2 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp); Xref=Rhea:RHEA:24080, Rhea:RHEA-COMP:9671, Rhea:RHEA-COMP:9705, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57912, ChEBI:CHEBI:78442, ChEBI:CHEBI:78535, ChEBI:CHEBI:456215; EC=6.1.1.2;.
GENATLAS Biochemistry:
tryptophanyl-tRNA synthetase 2,mitochondrial

Enzyme Numbers (IUBMB) for WARS2 Gene

Phenotypes From GWAS Catalog for WARS2 Gene

Gene Ontology (GO) - Molecular Function for WARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004830 tryptophan-tRNA ligase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with WARS2: view
genes like me logo Genes that share phenotypes with WARS2: view

Human Phenotype Ontology for WARS2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WARS2 Gene

MGI Knock Outs for WARS2:
  • Wars2 Wars2<tm1.1(KOMP)Vlcg>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WARS2

No data available for Transcription Factor Targets and HOMER Transcription for WARS2 Gene

Localization for WARS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WARS2 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WARS2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IBA,IDA --
GO:0005759 mitochondrial matrix TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with WARS2: view

Pathways & Interactions for WARS2 Gene

PathCards logo

SuperPathways for WARS2 Gene

genes like me logo Genes that share pathways with WARS2: view

Pathways by source for WARS2 Gene

1 KEGG pathway for WARS2 Gene

Gene Ontology (GO) - Biological Process for WARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006436 tryptophanyl-tRNA aminoacylation IBA 21873635
GO:0070183 mitochondrial tryptophanyl-tRNA aminoacylation IBA 21873635
genes like me logo Genes that share ontologies with WARS2: view

No data available for SIGNOR curated interactions for WARS2 Gene

Drugs & Compounds for WARS2 Gene

(4) Drugs for WARS2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tryptophan Approved, Withdrawn Nutra Target, Enzyme, inhibitor, substrate 106
Adenosine monophosphate Approved, Investigational Nutra 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(4) Additional Compounds for WARS2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8
genes like me logo Genes that share compounds with WARS2: view

Transcripts for WARS2 Gene

mRNA/cDNA for WARS2 Gene

8 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WARS2

Alternative Splicing Database (ASD) splice patterns (SP) for WARS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - - -
SP3:

Relevant External Links for WARS2 Gene

GeneLoc Exon Structure for
WARS2

Expression for WARS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WARS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WARS2 Gene

This gene is overexpressed in Adrenal (11.2), Salivary gland (6.6), and Islet of Langerhans (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WARS2 Gene



Protein tissue co-expression partners for WARS2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WARS2

SOURCE GeneReport for Unigene cluster for WARS2 Gene:

Hs.523506

mRNA Expression by UniProt/SwissProt for WARS2 Gene:

Q9UGM6-SYWM_HUMAN
Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for WARS2 Gene

  • Nervous system(4.6)
  • Kidney(4.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with WARS2: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WARS2 Gene

Orthologs for WARS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WARS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WARS2 29 30
  • 99.44 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WARS2 29 30
  • 88.43 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Wars2 29 16 30
  • 85.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WARS2 29 30
  • 85.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wars2 29
  • 84.63 (n)
Oppossum
(Monodelphis domestica)
Mammalia WARS2 30
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WARS2 30
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WARS2 29 30
  • 67.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WARS2 30
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wars2 29
  • 65.45 (n)
Str.6744 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.6583 29
Zebrafish
(Danio rerio)
Actinopterygii wars2 29 30
  • 61.63 (n)
OneToOne
wufb77g08 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011744 29
  • 55.2 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7441 29 30 31
  • 55.14 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea prx-10 29 30
  • 48.65 (n)
OneToOne
wrs-2 31
  • 42 (a)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21825g 29
  • 51.95 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR089C 29
  • 50.88 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSW1 29 30 32
  • 48.93 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons OVA4 29
  • 49.95 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0743400 29
  • 48.31 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes msw1 29
  • 47.63 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6568 30
  • 42 (a)
OneToOne
Species where no ortholog for WARS2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WARS2 Gene

ENSEMBL:
Gene Tree for WARS2 (if available)
TreeFam:
Gene Tree for WARS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WARS2: view image
Alliance of Genome Resources:
Additional Orthologs for WARS2

Paralogs for WARS2 Gene

Paralogs for WARS2 Gene

Pseudogenes.org Pseudogenes for WARS2 Gene

genes like me logo Genes that share paralogs with WARS2: view

Variants for WARS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WARS2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
1028002 Uncertain Significance: Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 119,032,978(-) G/A
NM_015836.4(WARS2):c.1016C>T (p.Ser339Leu)
MISSENSE_VARIANT,THREE_PRIME_UTR
1029412 Uncertain Significance: Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 119,076,347(-) G/A
NM_015836.4(WARS2):c.348+3C>T
INTRON
1029413 Uncertain Significance: Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 119,045,607(-) C/T
NM_015836.4(WARS2):c.404G>A (p.Arg135Gln)
MISSENSE
1029414 Uncertain Significance: Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 119,033,095(-) G/A
NM_015836.4(WARS2):c.899C>T (p.Ala300Val)
MISSENSE_VARIANT,THREE_PRIME_UTR
1031940 Uncertain Significance: Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 119,042,292(-) G/A
NM_015836.4(WARS2):c.487C>T (p.Leu163Phe)
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for WARS2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for WARS2 Gene

Variant ID Type Subtype PubMed ID
dgv16n21 CNV loss 19592680
esv2475310 CNV deletion 19546169
nsv521813 CNV loss 19592680
nsv524681 CNV gain 19592680
nsv831192 CNV gain 17160897
nsv946173 CNV duplication 23825009
nsv946174 CNV duplication 23825009
nsv997707 CNV gain 25217958

Variation tolerance for WARS2 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WARS2 Gene

Human Gene Mutation Database (HGMD)
WARS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WARS2
Leiden Open Variation Database (LOVD)
WARS2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WARS2 Gene

Disorders for WARS2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for WARS2 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search WARS2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SYWM_HUMAN
  • Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures (NEMMLAS) [MIM:617710]: An autosomal recessive, mitochondrial disorder with a broad phenotypic spectrum ranging from severe neonatal lactic acidosis, encephalomyopathy and early death to an attenuated course with milder manifestations. Clinical features include delayed psychomotor development, intellectual disability, hypotonia, dystonia, ataxia, and spasticity. Severe combined respiratory chain deficiency may be found in severely affected individuals. {ECO:0000269 PubMed:28236339, ECO:0000269 PubMed:28650581, ECO:0000269 PubMed:28905505}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for WARS2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with WARS2: view

No data available for Genatlas for WARS2 Gene

Publications for WARS2 Gene

  1. Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase. (PMID: 10828066) Jorgensen R … Justesen J (The Journal of biological chemistry 2000) 2 3 4 22
  2. Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. (PMID: 28236339) Musante L … Kuss AW (Human mutation 2017) 3 4 72
  3. Biallelic variants in WARS2 encoding mitochondrial tryptophanyl-tRNA synthase in six individuals with mitochondrial encephalopathy. (PMID: 28905505) Wortmann SB … Rodenburg RJ (Human mutation 2017) 3 4 72
  4. Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3-->p13.1 by radiation hybrid mapping. (PMID: 10072595) Martinez-Dominguez MT … Hansen LL (Cytogenetics and cell genetics 1998) 2 3 22
  5. Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy. (PMID: 28650581) Theisen BE … Fatemi A (American journal of medical genetics. Part A 2017) 3 4

Products for WARS2 Gene

Sources for WARS2 Gene