Aliases for WARS2 Gene
External Ids for WARS2 Gene
Previous GeneCards Identifiers for WARS2 Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for WARS2 Gene
WARS2 (Tryptophanyl TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with WARS2 include Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures and Lactic Acidosis. Among its related pathways are tRNA Aminoacylation and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleotide binding and tryptophan-tRNA ligase activity. An important paralog of this gene is WARS1.
UniProtKB/Swiss-Prot Summary for WARS2 Gene
Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.