Aliases for WARS2 Gene
Aliases for WARS2 Gene
External Ids for WARS2 Gene
- HGNC: 12730
- Entrez Gene: 10352
- Ensembl: ENSG00000116874
- OMIM: 604733
- UniProtKB: Q9UGM6
Previous GeneCards Identifiers for WARS2 Gene
- GC01M120022
- GC01M118413
- GC01M118720
- GC01M118920
- GC01M119286
- GC01M119573
- GC01M117432
Summaries for WARS2 Gene
-
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for WARS2 Gene
WARS2 (Tryptophanyl TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with WARS2 include Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are tRNA Aminoacylation and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleotide binding and tryptophan-tRNA ligase activity.
UniProtKB/Swiss-Prot for WARS2 Gene
-
Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.
Additional gene information for WARS2 Gene
- Monarch Initiative
- Search for WARS2 at DataMed
- Search for WARS2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WARS2 Gene
Genomics for WARS2 Gene
GeneHancer (GH) Regulatory Elements for WARS2 Gene
Promoters and enhancers for WARS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around WARS2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the WARS2 gene promoter:
-
- AML1a
- POU2F1c
- POU2F1b
- POU2F1a
- POU2F1
- aMEF-2
- MEF-2
- MEF-2A
- LCR-F1
- POU3F2
Regulatory Element Products
Genomic Locations for WARS2 Gene
Genomic Locations for WARS2 Gene
- chr1:119,031,216-119,140,788
- (GRCh38/hg38)
- Size:
- 109,573 bases
- Orientation:
- Minus strand
- chr1:119,573,839-119,683,295
- (GRCh37/hg19)
- Size:
- 109,457 bases
- Orientation:
- Minus strand
Genomic View for WARS2 Gene
Genes around WARS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p12 by Entrez Gene
- 1p12 by HGNC
- 1p12 by Ensembl
WARS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WARS2 Gene
Proteins for WARS2 Gene
-
Protein details for WARS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UGM6-SYWM_HUMAN
- Recommended name:
- Tryptophan--tRNA ligase, mitochondrial
- Protein Accession:
- Q9UGM6
- B1ALR1
- B2R9D4
- Q53FT4
- Q5VUD2
- Q86TQ0
Protein attributes for WARS2 Gene
- Size:
- 360 amino acids
- Molecular mass:
- 40147 Da
- Quaternary structure:
- No Data Available
Protein Expression for WARS2 Gene
Post-translational modifications for WARS2 Gene
Other Protein References for WARS2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for WARS2
- Novus Biologicals Antibodies for WARS2
- Invitrogen Antibodies for WARS2
- GeneTex WARS2 Antibody for WARS2
-
Boster Bio Antibodies for WARS2
Protein Products
-
OriGene Purified Proteins for WARS2
- Search Origene for MassSpec and Protein Over-expression Lysates for WARS2
- Origene Custom Protein Services for WARS2
- Search GeneTex for Proteins for WARS2
-
Abcam proteins for WARS2
Assay Products
No data available for DME Specific Peptides for WARS2 Gene
Domains & Families for WARS2 Gene
Gene Families for WARS2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for WARS2 Gene
Suggested Antigen Peptide Sequences for WARS2 Gene
Graphical View of Domain Structure for InterPro Entry
Q9UGM6- Family:
-
- Belongs to the class-I aminoacyl-tRNA synthetase family.
Function for WARS2 Gene
Molecular function for WARS2 Gene
- UniProtKB/Swiss-Prot Function:
- Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).
- GENATLAS Biochemistry:
- tryptophanyl-tRNA synthetase 2,mitochondrial
Enzyme Numbers (IUBMB) for WARS2 Gene
Phenotypes From GWAS Catalog for WARS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004812 | aminoacyl-tRNA ligase activity | IEA | -- |
| GO:0004830 | tryptophan-tRNA ligase activity | TAS | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016874 | ligase activity | IEA | -- |
Phenotypes for WARS2 Gene
- MGI mutant phenotypes for WARS2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for WARS2:
Animal Models for WARS2 Gene
- MGI Knock Outs for WARS2:
-
- Wars2 Wars2<tm1.1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for WARS2
-
CRISPR Products
-
OriGene CRISPR knockouts for WARS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WARS2
- genomics-online: gRNA clones - Search results for 99 available WARS2 gene related products
- Overview of 99 available WARS2 gene related products
- Applied Biological Materials CRISPR for WARS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for WARS2
- GenScript: Design CRISPR guide RNA sequences for WARS2
miRNA for WARS2 Gene
- miRTarBase miRNAs that target WARS2
-
- hsa-mir-98-5p (MIRT027840)
- hsa-let-7b-5p (MIRT032492)
- hsa-mir-1277-5p (MIRT265715)
- hsa-mir-4503 (MIRT265716)
- hsa-mir-6792-5p (MIRT550786)
- hsa-mir-570-3p (MIRT550787)
- hsa-mir-4692 (MIRT550788)
- hsa-mir-4514 (MIRT550789)
- hsa-mir-4269 (MIRT550790)
- hsa-mir-6715b-5p (MIRT550791)
- hsa-mir-4742-5p (MIRT550792)
- hsa-mir-656-3p (MIRT550793)
- hsa-mir-646 (MIRT550794)
- hsa-mir-551b-5p (MIRT550795)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for WARS2
- Browse OriGene Inhibitory RNA Products For WARS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WARS2
- genomics-online: shRNA clones - Search results for 99 available WARS2 gene related products
- Overview of 99 available WARS2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for WARS2
- VectorBuilder custom plasmid, inducible vectors for WARS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WARS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WARS2
- Applied Biological Materials Clones for WARS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for WARS2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WARS2 Gene
Localization for WARS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WARS2 Gene
- Mitochondrion matrix.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| plasma membrane | 4 |
| nucleus | 1 |
- Mitochondria (3)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IDA,IEA | -- |
| GO:0005759 | mitochondrial matrix | TAS | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for WARS2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | tRNA Aminoacylation | ||
| 2 | Gene Expression |
.48
|
|
Pathways by source for WARS2 Gene
3 Reactome pathways for WARS2 Gene
1 KEGG pathway for WARS2 Gene
Interacting Proteins for WARS2 Gene
GPS-Prot Interaction Network for WARS2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001570 | vasculogenesis | IEA | -- |
| GO:0006412 | translation | IEA | -- |
| GO:0006418 | tRNA aminoacylation for protein translation | TAS | -- |
| GO:0006436 | tryptophanyl-tRNA aminoacylation | IEA | -- |
| GO:0070183 | mitochondrial tryptophanyl-tRNA aminoacylation | IBA | -- |
No data available for SIGNOR curated interactions for WARS2 Gene
Drugs & Compounds for WARS2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| L-Tryptophan | Approved, Withdrawn | Nutra | Positive, Allosteric regulator, Inhibition, Inhibitor, Target, Enzyme, inhibitor, substrate | 0 | ||
| Phosphoric acid | Approved | Pharma | 0 | |||
| Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for WARS2 Gene
mRNA/cDNA for WARS2 Gene
- (13) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000369426 2811 bps (uc001ehm.4)
- ENST00000235521 2800 bps (uc001ehn.4)
- ENST00000495746 621 bps (uc057juw.1)
- ENST00000497402 712 bps (uc057jux.1)
- ENST00000497761 895 bps (uc057juz.1)
Unigene Clusters for WARS2 Gene
- Tryptophanyl tRNA synthetase 2, mitochondrial:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for WARS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WARS2
- genomics-online: gRNA clones - Search results for 99 available WARS2 gene related products
- Overview of 99 available WARS2 gene related products
- Applied Biological Materials CRISPR for WARS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for WARS2
- GenScript: Design CRISPR guide RNA sequences for WARS2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for WARS2
- Browse OriGene Inhibitory RNA Products For WARS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WARS2
- genomics-online: shRNA clones - Search results for 99 available WARS2 gene related products
- Overview of 99 available WARS2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for WARS2
- VectorBuilder custom plasmid, inducible vectors for WARS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WARS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WARS2
- Applied Biological Materials Clones for WARS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||
| SP3: |
Expression for WARS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Adrenal (11.2), Salivary gland (6.6), and Islet of Langerhans (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WARS2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of WARS2 Gene:
WARS2SOURCE GeneReport for Unigene cluster for WARS2 Gene:
Hs.523506mRNA Expression by UniProt/SwissProt for WARS2 Gene:
Q9UGM6-SYWM_HUMAN
Tissue specificity:
Brain.
Evidence on tissue expression from TISSUES for WARS2 Gene
- Nervous system(4.6)
- Kidney(4.3)
- Pancreas(2.3)
Primer Products
-
OriGene qPCR primer pairs for WARS2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WARS2 Gene
Orthologs for WARS2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | WARS2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | WARS2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Wars2 16 34 33 |
|
||
| dog (Canis familiaris) |
Mammalia | WARS2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Wars2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | WARS2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | WARS2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | WARS2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | WARS2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | wars2 33 |
|
||
| Str.6744 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6583 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | wars2 34 33 |
|
OneToOne | |
| wufb77g08 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011744 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7441 34 35 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | prx-10 34 33 |
|
OneToOne | |
| wrs-2 35 |
|
|
|||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E21825g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACR089C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MSW1 36 34 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | OVA4 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0743400 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | msw1 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6568 34 |
|
OneToOne |
- Species where no ortholog for WARS2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for WARS2 Gene
- ENSEMBL:
- Gene Tree for WARS2 (if available)
- TreeFam:
- Gene Tree for WARS2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WARS2: view image
Paralogs for WARS2 Gene
Pseudogenes.org Pseudogenes for WARS2 Gene
No data available for Paralogs for WARS2 Gene
Variants for WARS2 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs139548132 | pathogenic, NEURODEVELOPMENTAL DISORDER, MITOCHONDRIAL, WITH ABNORMAL MOVEMENTS AND LACTIC ACIDOSIS, WITH OR WITHOUT SEIZURES, Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures (NEMMLAS) [MIM:617710] | 119,140,608(-) | A/C/G/T | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant | |
| rs145867327 | pathogenic, NEURODEVELOPMENTAL DISORDER, MITOCHONDRIAL, WITH ABNORMAL MOVEMENTS AND LACTIC ACIDOSIS, WITH OR WITHOUT SEIZURES, Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures (NEMMLAS) [MIM:617710] | 119,033,056(-) | T/A | 3_prime_UTR_variant, coding_sequence_variant, missense_variant | |
| rs563341344 | Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures (NEMMLAS) [MIM:617710] | 119,032,940(-) | C/T | 3_prime_UTR_variant, coding_sequence_variant, missense_variant | |
| rs746478253 | pathogenic, NEURODEVELOPMENTAL DISORDER, MITOCHONDRIAL, WITH ABNORMAL MOVEMENTS AND LACTIC ACIDOSIS, WITH OR WITHOUT SEIZURES | 119,033,197(-) | GGG/GG | 3_prime_UTR_variant, coding_sequence_variant, frameshift | |
| rs766501807 | Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures (NEMMLAS) [MIM:617710] | 119,076,467(-) | G/A/C | 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant, synonymous_variant |
Residual Variation Intolerance Score:
65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.88;
74.19% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WARS2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WARS2 Gene
Disorders for WARS2 Gene
(3) MalaCards diseases for WARS2 Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures |
|
|
| autosomal recessive non-syndromic intellectual disability |
|
|
| long qt syndrome 1 |
|
|
Search WARS2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SYWM_HUMAN- Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures (NEMMLAS) [MIM:617710]: An autosomal recessive, mitochondrial disorder with a broad phenotypic spectrum ranging from severe neonatal lactic acidosis, encephalomyopathy and early death to an attenuated course with milder manifestations. Clinical features include delayed psychomotor development, intellectual disability, hypotonia, dystonia, ataxia, and spasticity. Severe combined respiratory chain deficiency may be found in severely affected individuals. {ECO:0000269 PubMed:28236339, ECO:0000269 PubMed:28650581, ECO:0000269 PubMed:28905505}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for WARS2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for WARS2 Gene
Publications for WARS2 Gene
- Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase. (PMID: 10828066) Jorgensen R … Justesen J (The Journal of biological chemistry 2000) 2 3 4 22 58
- Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3-->p13.1 by radiation hybrid mapping. (PMID: 10072595) Martinez-Dominguez MT … Hansen LL (Cytogenetics and cell genetics 1998) 2 3 22 58
- Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. (PMID: 28236339) Musante L … Kuss AW (Human mutation 2017) 3 4 58
- Biallelic variants in WARS2 encoding mitochondrial tryptophanyl-tRNA synthase in six individuals with mitochondrial encephalopathy. (PMID: 28905505) Wortmann SB … Rodenburg RJ (Human mutation 2017) 3 4 58
- Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy. (PMID: 28650581) Theisen BE … Fatemi A (American journal of medical genetics. Part A 2017) 3 4 58
Products for WARS2 Gene
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cyagen custom Knockout/knockin (KOKI) mouse models for WARS2
- VectorBuilder custom plasmid, inducible vectors for WARS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WARS2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 20 available WARS2 Antibodies ranked by validation data
- Compare Top WARS2 Antibodies
- antibodies-online: Search results for available WARS2 related products ranked by validation data
- antibodies-online: Search results for 39 available WARS2 Proteins ranked by validation data
- Compare Top WARS2 Proteins
- genomics-online: cdna clones - Search results for 99 available WARS2 gene related products
- Overview of 99 available WARS2 gene related products
- orf clones - Search results for 99 available WARS2 gene related products
- Overview of 99 available WARS2 gene related products
- genomics-online: gRNA clones - Search results for 99 available WARS2 gene related products
- Overview of 99 available WARS2 gene related products
- genomics-online: primer clones - Search results for 99 available WARS2 gene related products
- Overview of 99 available WARS2 gene related products
- genomics-online: shRNA clones - Search results for 99 available WARS2 gene related products
- Overview of 99 available WARS2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WARS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WARS2
- GeneCopoeia miRNA 3'UTR Target clone products for WARS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WARS2
- Boster Bio Antibodies for WARS2
- Browse Boster Bio ELISA Kits
Sources for WARS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt