Aliases for WARS2 Gene
External Ids for WARS2 Gene
Previous GeneCards Identifiers for WARS2 Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for WARS2 Gene
WARS2 (Tryptophanyl TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with WARS2 include Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are tRNA Aminoacylation and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleotide binding and tryptophan-tRNA ligase activity. An important paralog of this gene is WARS1.
UniProtKB/Swiss-Prot Summary for WARS2 Gene
Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.