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Aliases for VXN Gene

Aliases for VXN Gene

  • Vexin 2 3
  • Chromosome 8 Open Reading Frame 46 2 5
  • C8orf46 3 5
  • Uncharacterized Protein C8orf46 3

External Ids for VXN Gene

Previous HGNC Symbols for VXN Gene

  • C8orf46

Summaries for VXN Gene

GeneCards Summary for VXN Gene

VXN (Vexin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for VXN Gene

  • Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis.

Additional gene information for VXN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VXN Gene

Genomics for VXN Gene

GeneHancer (GH) Regulatory Elements for VXN Gene

Promoters and enhancers for VXN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J066458 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 681.1 +1.9 1868 6.5 PKNOX1 FOXA2 RAD21 RARA ZNF143 FOS MIXL1 ZNF654 CEBPB REST VXN ADHFE1 RNU6-1324P LOC100131770
GH08J066493 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 656.4 +34.2 34222 1.6 MEIS2 PKNOX1 SAP130 L3MBTL2 MZF1 GABPA SMARCA4 IKZF1 GABPB1 NR2C1 VXN MYBL1 RNU6-1324P LOC100131770
GH08J066494 Promoter/Enhancer 0.9 EPDnew ENCODE dbSUPER 650.3 +33.3 33318 0.2 VXN RRS1-AS1 RRS1 ADHFE1 RNU6-1324P LOC100131770
GH08J066459 Enhancer 0.5 ENCODE dbSUPER 650.7 -1.7 -1662 0.2 SIN3A VXN LOC102724687 ADHFE1
GH08J066438 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 24.5 -20.1 -20054 3.9 PKNOX1 RB1 ARID4B SIN3A BATF ZNF2 RAD21 ZNF335 ZNF121 EGR1 VXN ADHFE1 ENSG00000272010 LOC102724687 GC08P066013
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VXN on UCSC Golden Path with GeneCards custom track

Genomic Locations for VXN Gene

Genomic Locations for VXN Gene
chr8:66,460,003-66,518,524
(GRCh38/hg38)
Size:
58,522 bases
Orientation:
Plus strand
chr8:67,372,238-67,430,759
(GRCh37/hg19)
Size:
58,522 bases
Orientation:
Plus strand

Genomic View for VXN Gene

Genes around VXN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VXN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VXN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VXN Gene

Proteins for VXN Gene

  • Protein details for VXN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAG6-VEXIN_HUMAN
    Recommended name:
    Vexin
    Protein Accession:
    Q8TAG6
    Secondary Accessions:
    • B2RDC3
    • B4DFU4
    • C9J814
    • C9JCS3

    Protein attributes for VXN Gene

    Size:
    207 amino acids
    Molecular mass:
    22584 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28400.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37870.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for VXN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VXN Gene

Post-translational modifications for VXN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VXN Gene

No data available for DME Specific Peptides for VXN Gene

Domains & Families for VXN Gene

Gene Families for VXN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for VXN Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TAG6

UniProtKB/Swiss-Prot:

VEXIN_HUMAN :
  • Belongs to the vexin family.
Family:
  • Belongs to the vexin family.
genes like me logo Genes that share domains with VXN: view

No data available for Suggested Antigen Peptide Sequences for VXN Gene

Function for VXN Gene

Molecular function for VXN Gene

UniProtKB/Swiss-Prot Function:
Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis.

Phenotypes From GWAS Catalog for VXN Gene

genes like me logo Genes that share phenotypes with VXN: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VXN Gene

Localization for VXN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VXN Gene

Cell membrane. Nucleus. Note=Nuclear localization is essential for its function in neurogenesis. {ECO:0000250 UniProtKB:Q8BG31}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VXN gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with VXN: view

Pathways & Interactions for VXN Gene

No Data Available

Interacting Proteins for VXN Gene

Gene Ontology (GO) - Biological Process for VXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022008 neurogenesis ISS --
GO:0030182 neuron differentiation ISS --
genes like me logo Genes that share ontologies with VXN: view

No data available for Pathways by source and SIGNOR curated interactions for VXN Gene

Drugs & Compounds for VXN Gene

No Compound Related Data Available

Transcripts for VXN Gene

mRNA/cDNA for VXN Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VXN Gene

No ASD Table

Relevant External Links for VXN Gene

GeneLoc Exon Structure for
VXN
ECgene alternative splicing isoforms for
VXN

Expression for VXN Gene

NURSA nuclear receptor signaling pathways regulating expression of VXN Gene:

VXN

Evidence on tissue expression from TISSUES for VXN Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with VXN: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VXN Gene

Orthologs for VXN Gene

This gene was present in the common ancestor of chordates.

Orthologs for VXN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf46 34 33
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C29H8orf46 33
  • 87.03 (n)
C8orf46 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 3110035E14Rik 34 33
  • 84.48 (n)
OneToOne
Vxn 16
rat
(Rattus norvegicus)
Mammalia RGD1561849 33
  • 83.66 (n)
cow
(Bos Taurus)
Mammalia C14H8orf46 34 33
  • 83.09 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C8orf46 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C8orf46 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H8orf46 33
  • 60.13 (n)
C8orf46 34
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C8orf46 34
  • 41 (a)
OneToOne
Species where no ortholog for VXN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VXN Gene

ENSEMBL:
Gene Tree for VXN (if available)
TreeFam:
Gene Tree for VXN (if available)

Paralogs for VXN Gene

Pseudogenes.org Pseudogenes for VXN Gene

genes like me logo Genes that share paralogs with VXN: view

No data available for Paralogs for VXN Gene

Variants for VXN Gene

Sequence variations from dbSNP and Humsavar for VXN Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000066410 -- 66,504,233(+) G/A/C intron_variant
rs1000348101 -- 66,499,244(+) G/C/T intron_variant
rs1000686423 -- 66,514,537(+) A/G intron_variant
rs1000709993 -- 66,517,541(+) T/C 3_prime_UTR_variant
rs1000951177 -- 66,506,225(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VXN Gene

Variant ID Type Subtype PubMed ID
nsv1026137 CNV loss 25217958
nsv516599 CNV loss 19592680
nsv951440 CNV deletion 24416366

Variation tolerance for VXN Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VXN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VXN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VXN Gene

Disorders for VXN Gene

No disorders were found for VXN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VXN Gene

Publications for VXN Gene

  1. C8orf46 homolog encodes a novel protein Vexin that is required for neurogenesis in Xenopus laevis. (PMID: 29518376) Moore KB … Vetter ML (Developmental biology 2018) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Functionally enigmatic genes: a case study of the brain ignorome. (PMID: 24523945) Pandey AK … Williams RW (PloS one 2014) 3 58
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58

Products for VXN Gene

Sources for VXN Gene

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