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Aliases for VWC2 Gene

Aliases for VWC2 Gene

  • Von Willebrand Factor C Domain Containing 2 2 3 5
  • Von Willebrand Factor C Domain-Containing Protein 2 3 4
  • Brain-Specific Chordin-Like Protein 3 4
  • Brorin 2 3
  • Brain-Specific Chordin-Like 2
  • PSST739 3
  • UNQ739 3

External Ids for VWC2 Gene

Summaries for VWC2 Gene

Entrez Gene Summary for VWC2 Gene

  • This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009]

GeneCards Summary for VWC2 Gene

VWC2 (Von Willebrand Factor C Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is VWC2L.

UniProtKB/Swiss-Prot for VWC2 Gene

  • BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).

Additional gene information for VWC2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWC2 Gene

Genomics for VWC2 Gene

GeneHancer (GH) Regulatory Elements for VWC2 Gene

Promoters and enhancers for VWC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I049773 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.8 0.0 -30 0.1 EZH2 VWC2 ENSG00000279104
GH07I049774 Enhancer 0.6 FANTOM5 dbSUPER 561.7 +1.1 1093 0.3 SUZ12 EZH2 VWC2 GNL2P1
GH07I049775 Enhancer 0.6 ENCODE dbSUPER 550.8 +0.8 797 0 SUZ12 EZH2 VWC2 GNL2P1
GH07I049776 Enhancer 0.5 ENCODE dbSUPER 550.8 +1.6 1579 0.2 EZH2 VWC2 GNL2P1
GH07I049778 Enhancer 0.5 dbSUPER 8.6 +5.3 5313 0.9 BATF BCLAF1 IKZF2 ATF2 RUNX3 SPI1 VWC2 GNL2P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VWC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VWC2 gene promoter:

Genomic Locations for VWC2 Gene

Genomic Locations for VWC2 Gene
148,290 bases
Plus strand

Genomic View for VWC2 Gene

Genes around VWC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VWC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VWC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWC2 Gene

Proteins for VWC2 Gene

  • Protein details for VWC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6UXE2

    Protein attributes for VWC2 Gene

    325 amino acids
    Molecular mass:
    35282 Da
    Quaternary structure:
    • Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

neXtProt entry for VWC2 Gene

Post-translational modifications for VWC2 Gene

No Post-translational modifications

Other Protein References for VWC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VWC2 Gene

Domains & Families for VWC2 Gene

Gene Families for VWC2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for VWC2 Gene


Suggested Antigen Peptide Sequences for VWC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VWC2: view

No data available for UniProtKB/Swiss-Prot for VWC2 Gene

Function for VWC2 Gene

Molecular function for VWC2 Gene

UniProtKB/Swiss-Prot Function:
BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).

Phenotypes From GWAS Catalog for VWC2 Gene

Gene Ontology (GO) - Molecular Function for VWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with VWC2: view
genes like me logo Genes that share phenotypes with VWC2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VWC2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VWC2 Gene

Localization for VWC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWC2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Cell junction, synapse.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VWC2 gene
Compartment Confidence
extracellular 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for VWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane IEA --
GO:0005614 interstitial matrix IEA --
GO:0005615 extracellular space IEA,ISS 17400546
genes like me logo Genes that share ontologies with VWC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VWC2 Gene

Pathways & Interactions for VWC2 Gene

No Data Available

Interacting Proteins for VWC2 Gene

Gene Ontology (GO) - Biological Process for VWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030514 negative regulation of BMP signaling pathway IEA,ISS 17400546
GO:0045666 positive regulation of neuron differentiation ISS,IEA 17400546
genes like me logo Genes that share ontologies with VWC2: view

No data available for Pathways by source and SIGNOR curated interactions for VWC2 Gene

Drugs & Compounds for VWC2 Gene

No Compound Related Data Available

Transcripts for VWC2 Gene

mRNA/cDNA for VWC2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VWC2 Gene

Von Willebrand factor C domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VWC2 Gene

No ASD Table

Relevant External Links for VWC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VWC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VWC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VWC2 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.2), Ovary (x6.4), Heart - Atrial Appendage (x6.0), Brain - Cerebellar Hemisphere (x5.5), and Brain - Cerebellum (x4.7).

Protein differential expression in normal tissues from HIPED for VWC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VWC2 Gene

Protein tissue co-expression partners for VWC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VWC2 Gene:


SOURCE GeneReport for Unigene cluster for VWC2 Gene:


Evidence on tissue expression from TISSUES for VWC2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with VWC2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VWC2 Gene

Orthologs for VWC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VWC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VWC2 33 34
  • 99.9 (n)
(Canis familiaris)
Mammalia VWC2 34
  • 92 (a)
(Bos Taurus)
Mammalia VWC2 33 34
  • 88 (n)
(Mus musculus)
Mammalia Vwc2 33 16 34
  • 87.86 (n)
(Rattus norvegicus)
Mammalia Vwc2 33
  • 87.45 (n)
(Monodelphis domestica)
Mammalia VWC2 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia VWC2 34
  • 78 (a)
(Gallus gallus)
Aves VWC2 33 34
  • 78.33 (n)
(Anolis carolinensis)
Reptilia VWC2 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vwc2 33
  • 65.52 (n)
(Danio rerio)
Actinopterygii vwc2 33 34
  • 74.03 (n)
Species where no ortholog for VWC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VWC2 Gene

Gene Tree for VWC2 (if available)
Gene Tree for VWC2 (if available)

Paralogs for VWC2 Gene

Paralogs for VWC2 Gene

(1) SIMAP similar genes for VWC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VWC2: view

Variants for VWC2 Gene

Sequence variations from dbSNP and Humsavar for VWC2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000018041 -- 49,791,271(+) C/G intron_variant
rs1000018716 -- 49,882,754(+) T/C intron_variant
rs1000043554 -- 49,776,149(+) G/A/T intron_variant
rs1000057468 -- 49,903,993(+) A/G intron_variant
rs1000062416 -- 49,841,043(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VWC2 Gene

Variant ID Type Subtype PubMed ID
esv3613116 CNV gain 21293372
nsv606896 CNV gain 21841781
nsv606897 CNV gain 21841781
nsv830996 CNV gain 17160897

Variation tolerance for VWC2 Gene

Gene Damage Index Score: 10.45; 90.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VWC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VWC2 Gene

Disorders for VWC2 Gene

Additional Disease Information for VWC2

No disorders were found for VWC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VWC2 Gene

Publications for VWC2 Gene

  1. Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells. (PMID: 17400546) Koike N … Itoh N (The Journal of biological chemistry 2007) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network. (PMID: 25436638) Malinowski JR … Crawford DC (PloS one 2014) 3 58
  4. von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms. (PMID: 17483092) Zhang JL … Sebald W (The Journal of biological chemistry 2007) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for VWC2 Gene

Sources for VWC2 Gene

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