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This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009] See more...
Aliases for VWC2 Gene
Aliases for VWC2 Gene
External Ids for VWC2 Gene
- HGNC: 30200
- Entrez Gene: 375567
- Ensembl: ENSG00000188730
- OMIM: 611108
- UniProtKB: Q2TAL6
Summaries for VWC2 Gene
-
This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009]
GeneCards Summary for VWC2 Gene
VWC2 (Von Willebrand Factor C Domain Containing 2) is a Protein Coding gene. Diseases associated with VWC2 include Epilepsy, Familial Temporal Lobe, 4 and Spastic Paraplegia 20, Autosomal Recessive. An important paralog of this gene is VWC2L.
UniProtKB/Swiss-Prot Summary for VWC2 Gene
-
BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).
Additional gene information for VWC2 Gene
- HGNC(30200)
- Entrez Gene(375567)
- Ensembl(ENSG00000188730)
- OMIM(611108)
- UniProtKB(Q2TAL6)
- Open Targets Platform(ENSG00000188730)
- Search for VWC2 at DataMed
- Search for VWC2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VWC2 Gene
Genomics for VWC2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for VWC2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J049773 | Promoter/Enhancer | 1.4 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 618.5 | +1.1 | 1063 | 3.4 | BACH1 EZH2 ZSCAN29 SIN3A | VWC2 HSALNG0057928 piR-38051-256 SPATA48 | |
| GH07J049778 | Enhancer | 0.5 | dbSUPER | 8.6 | +5.3 | 5336 | 0.9 | RUNX3 BCLAF1 BATF ATF2 SPI1 IKZF2 | VWC2 piR-38051-256 SPATA48 | |
| GH07J049802 | Enhancer | 0.3 | dbSUPER | 11.8 | +30.1 | 30069 | 2.3 | SMARCA4 | VWC2 piR-38051-256 SPATA48 | |
| GH07J049799 | Enhancer | 0.2 | dbSUPER | 11.6 | +26.8 | 26792 | 0.9 | VWC2 piR-38051-256 SPATA48 | ||
| GH07J049797 | Enhancer | 0.2 | dbSUPER | 11.6 | +25.2 | 25240 | 1.8 | VWC2 CDC14C piR-38051-256 SPATA48 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VWC2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VWC2
- Top Transcription factor binding sites by QIAGEN in the VWC2 gene promoter:
-
- aMEF-2
- AREB6
- Egr-3
- FOXL1
- LUN-1
- MEF-2A
- NF-1
- NF-kappaB1
- RelA
- YY1
Genomic Locations for VWC2 Gene
Genomic Locations for VWC2 Gene
- chr7:49,773,638-49,923,777
- (GRCh38/hg38)
- Size:
- 150,140 bases
- Orientation:
- Plus strand
- chr7:49,813,257-49,961,546
- (GRCh37/hg19)
- Size:
- 148,290 bases
- Orientation:
- Plus strand
Genomic View for VWC2 Gene
Genes around VWC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p12.2 by HGNC
- 7p12.2 by Entrez Gene
- 7p12.2 by Ensembl
VWC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VWC2 Gene
Proteins for VWC2 Gene
-
Protein details for VWC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q2TAL6-VWC2_HUMAN
- Recommended name:
- Brorin
- Protein Accession:
- Q2TAL6
- Q6UXE2
Protein attributes for VWC2 Gene
- Size:
- 325 amino acids
- Molecular mass:
- 35282 Da
- Quaternary structure:
-
- Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).
Protein Expression for VWC2 Gene
Post-translational modifications for VWC2 Gene
No Post-translational modifications
Other Protein References for VWC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for VWC2
- Invitrogen Antibodies for VWC2 (AFLGC-Vwc2)
- Sino Biological Antibodies for VWC2
Protein Products
-
OriGene Purified Proteins for VWC2
- Search Origene for MassSpec and Protein Over-expression Lysates for VWC2
- Origene Custom Protein Services for VWC2
- Novus Biologicals proteins for VWC2
- Sino Biological Cell Lysates for VWC2
- Sino Biological Recombinant Proteins for VWC2
- antibodies-online: Search results for available VWC2 related products ranked by validation data
Assay Products
- RayBiotech Custom Human Brorin ELISA
-
Custom Assay ServicesOriGene ELISA Kits for VWC2
- antibodies-online: Show 2 available VWC2 Elisa Kits ranked by validation data
- Compare Top VWC2 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for VWC2
- Sino Biological Assays for VWC2
No data available for DME Specific Peptides for VWC2 Gene
Domains & Families for VWC2 Gene
Gene Families for VWC2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for VWC2 Gene
- InterPro:
- Blocks:
-
- von Willebrand factor, type C
- ProtoNet:
Suggested Antigen Peptide Sequences for VWC2 Gene
- GenScript: Design optimal peptide antigens:
-
- von Willebrand factor C domain-containing protein 2 (VWC2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for VWC2 Gene
Function for VWC2 Gene
Molecular function for VWC2 Gene
- UniProtKB/Swiss-Prot Function:
- BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).
Phenotypes From GWAS Catalog for VWC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for VWC2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for VWC2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VWC2 - Select products 50% OFF >
- * VWC2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for VWC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VWC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for VWC2
miRNA for VWC2 Gene
- miRTarBase miRNAs that target VWC2
-
- hsa-miR-122-5p (MIRT761361)
- hsa-miR-1307-3p (MIRT762476)
- hsa-miR-143-5p (MIRT762706)
- hsa-miR-3135b (MIRT764957)
- hsa-miR-3652 (MIRT766318)
- hsa-miR-4430 (MIRT768953)
- hsa-miR-4638-5p (MIRT770535)
- hsa-miR-504-3p (MIRT773081)
- hsa-miR-5190 (MIRT773609)
- hsa-miR-5698 (MIRT775173)
- hsa-miR-6499-3p (MIRT776411)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VWC2
- Browse OriGene Inhibitory RNA Products For VWC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VWC2
Clone Products
- Applied Biological Materials (abm): Clones for VWC2 - Select products 50% OFF >
- * VWC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for VWC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VWC2
Cell Line Products
-
Horizon Cell Lines for VWC2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VWC2 Gene
Localization for VWC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VWC2 Gene
- Secreted, extracellular space, extracellular matrix, basement membrane. Cell junction, synapse.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 3 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005604 | basement membrane | IEA | -- |
| GO:0005614 | interstitial matrix | IEA | -- |
| GO:0005615 | extracellular space | IEA,ISS | 17400546 |
| GO:0030054 | cell junction | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for VWC2 Gene
Pathways & Interactions for VWC2 Gene
Interacting Proteins for VWC2 Gene
Selected Interacting proteins:
Q2TAL6-VWC2_HUMAN
ENSP00000341819
for VWC2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for VWC2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010811 | positive regulation of cell-substrate adhesion | IEA | -- |
| GO:0030514 | negative regulation of BMP signaling pathway | ISS | 17400546 |
| GO:0045666 | positive regulation of neuron differentiation | ISS | 17400546 |
No data available for Pathways by source and SIGNOR curated interactions for VWC2 Gene
Transcripts for VWC2 Gene
mRNA/cDNA for VWC2 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000340652 11322 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VWC2 - Select products 50% OFF >
- * VWC2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for VWC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VWC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for VWC2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VWC2
- Browse OriGene Inhibitory RNA Products For VWC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VWC2
Clone Products
- Applied Biological Materials (abm): Clones for VWC2 - Select products 50% OFF >
- * VWC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for VWC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VWC2
Relevant External Links for VWC2 Gene
- GeneLoc Exon Structure for
- VWC2
Expression for VWC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Horizontal Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- Mature Horizontal Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for VWC2 Gene
This gene is overexpressed in Heart - Left Ventricle (x8.2), Ovary (x6.4), Heart - Atrial Appendage (x6.0), Brain - Cerebellar Hemisphere (x5.5), and Brain - Cerebellum (x4.7).
This gene is overexpressed in Peripheral blood mononuclear cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VWC2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VWC2
SOURCE GeneReport for Unigene cluster for VWC2 Gene:
Hs.629302Evidence on tissue expression from TISSUES for VWC2 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for VWC2
-
OriGene qPCR primer pairs and template standards for VWC2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VWC2 Gene
Orthologs for VWC2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | VWC2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | VWC2 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | VWC2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Vwc2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Vwc2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | VWC2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | VWC2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | VWC2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | VWC2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vwc2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | vwc2 30 31 |
|
OneToOne |
- Species where no ortholog for VWC2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for VWC2 Gene
- ENSEMBL:
- Gene Tree for VWC2 (if available)
- TreeFam:
- Gene Tree for VWC2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for VWC2: view image
Paralogs for VWC2 Gene
Variants for VWC2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VWC2 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs769604 | - | p.Ala120Gly |
Gene Damage Index Score:
10.45;
90.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VWC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VWC2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VWC2 Gene
Disorders for VWC2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epilepsy, familial temporal lobe, 4 |
|
|
| spastic paraplegia 20, autosomal recessive |
|
|
Search VWC2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VWC2
No data available for UniProtKB/Swiss-Prot and Genatlas for VWC2 Gene
Publications for VWC2 Gene
- Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells. (PMID: 17400546) Koike N … Itoh N (The Journal of biological chemistry 2007) 2 3 4
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
- Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network. (PMID: 25436638) Malinowski JR … Crawford DC (PloS one 2014) 3
ExternalLinks
Products for VWC2 Gene
- Custom Antibody Services
- Custom Assay ServicesOriGene ELISA Kits for VWC2
- OriGene Purified Proteins for VWC2
- Search Origene for MassSpec and Protein Over-expression Lysates for VWC2
- Origene Custom Protein Services for VWC2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VWC2
- Browse OriGene Inhibitory RNA Products For VWC2
- OriGene qPCR primer pairs for VWC2
- OriGene qPCR primer pairs and template standards for VWC2
- OriGene CRISPR knockouts for VWC2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For VWC2
- Sino Biological Human cDNA Clone for VWC2
- Sino Biological Cell Lysates for VWC2
- Sino Biological Recombinant Proteins for VWC2
- Sino Biological Antibodies for VWC2
- Sino Biological Assays for VWC2
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for VWC2
- Novus Biologicals proteins for VWC2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for VWC2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for VWC2 (AFLGC-Vwc2)
- VectorBuilder Custom and pre-made DNA vectors for VWC2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for VWC2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for VWC2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for VWC2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for VWC2
- antibodies-online: Show 3 available VWC2 Antibodies ranked by validation data
- Compare Top VWC2 Antibodies
- antibodies-online: Show 2 available VWC2 Elisa Kits ranked by validation data
- Compare Top VWC2 Elisa Kits
- Quality Products:
- antibodies-online: Search results for available VWC2 related products ranked by validation data
- Horizon Cell Lines for VWC2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VWC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VWC2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for VWC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VWC2
- Browse Boster Bio Antibodies
- Boster Bio ELISA Kits for VWC2
Sources for VWC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB