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Aliases for VTRNA1-1 Gene

Subcategory (RNA class) for VTRNA1-1 Gene

vault RNA

Quality Score for this RNA gene is

3

Aliases for VTRNA1-1 Gene

  • Vault RNA 1-1 2 3 5
  • Vault RNA Component 1 2 3
  • VAULTRC1 3
  • Hvg-1 3
  • HVG1 3
  • VRNA 3
  • VR1 3

External Ids for VTRNA1-1 Gene

ORGUL Members for VTRNA1-1 Gene

Previous HGNC Symbols for VTRNA1-1 Gene

  • VAULTRC1

Previous GeneCards Identifiers for VTRNA1-1 Gene

  • GC05P140075
  • GC05P135238
  • GC05P140091
  • GC05P140094
  • GC05P140109
  • GC05P141421
  • GC05P141565
  • GC05P141667
  • GC05P141768
  • GC05P141868
  • GC05P141977
  • GC05P142077

Summaries for VTRNA1-1 Gene

Entrez Gene Summary for VTRNA1-1 Gene

  • Vaults are large cytoplasmic ribonucleoproteins of about 13 MD. They are composed of a major vault protein, MVP (MIM 605088), 2 minor vault proteins, TEP1 (MIM 601686) and PARP4 (MIM 607519), and a nontranslated RNA component, VTRNA1-1 (Kickhoefer et al., 1999 [PubMed 10551828]).[supplied by OMIM, Mar 2009]

GeneCards Summary for VTRNA1-1 Gene

VTRNA1-1 (Vault RNA 1-1) is an RNA Gene, and is affiliated with the vault RNA class.

Additional gene information for VTRNA1-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VTRNA1-1 Gene

Genomics for VTRNA1-1 Gene

GeneHancer (GH) Regulatory Elements for VTRNA1-1 Gene

Promoters and enhancers for VTRNA1-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I140710 Promoter/Enhancer 1.6 Ensembl ENCODE 550.8 -0.3 -291 1.9 CLOCK FEZF1 IRF4 YY1 ZNF213 ZNF143 SP3 SSRP1 ZNF610 GLIS1 GC05P142198 LOC105378198 VTRNA1-1 HARS2 PCDHB18P PURA WDR55 LOC102723915 HDAC3 PCDHGA6
GH05I140712 Enhancer 0.6 Ensembl 550.8 +0.8 826 0.2 SMARCA5 ZNF133 ZEB1 ZNF335 ZNF184 RBAK ZNF624 ADNP ZNF512 GC05P142198 LOC105378198 VTRNA1-1 PURA PCDHB18P HARS2 PCDHGB8P GC05P142207 VTRNA1-2 GC05P142218
GH05I140699 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.4 -10.6 -10588 1.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF766 ZMAT2 SRA1 WDR55 DND1 EIF4EBP3 SLC35A4 GC05P142198 VTRNA1-1 GC05P142218
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VTRNA1-1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VTRNA1-1 gene promoter:

Genomic Locations for VTRNA1-1 Gene

Genomic Locations for VTRNA1-1 Gene
chr5:140,711,275-140,711,373
(GRCh38/hg38)
Size:
99 bases
Orientation:
Plus strand
chr5:140,090,860-140,090,958
(GRCh37/hg19)

Genomic View for VTRNA1-1 Gene

Genes around VTRNA1-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VTRNA1-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VTRNA1-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTRNA1-1 Gene

Proteins for VTRNA1-1 Gene

Post-translational modifications for VTRNA1-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for VTRNA1-1 Gene

Domains & Families for VTRNA1-1 Gene

Gene Families for VTRNA1-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VTRNA1-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for VTRNA1-1 Gene

Function for VTRNA1-1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VTRNA1-1 Gene

Localization for VTRNA1-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for VTRNA1-1 Gene

Pathways & Interactions for VTRNA1-1 Gene

SuperPathways for VTRNA1-1 Gene

No Data Available

Interacting Proteins for VTRNA1-1 Gene

Gene Ontology (GO) - Biological Process for VTRNA1-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VTRNA1-1 Gene

Drugs & Compounds for VTRNA1-1 Gene

No Compound Related Data Available

Transcripts for VTRNA1-1 Gene

mRNA/cDNA for VTRNA1-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VTRNA1-1 Gene

No ASD Table

Relevant External Links for VTRNA1-1 Gene

GeneLoc Exon Structure for
VTRNA1-1
ECgene alternative splicing isoforms for
VTRNA1-1

Expression for VTRNA1-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VTRNA1-1 Gene

genes like me logo Genes that share expression patterns with VTRNA1-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VTRNA1-1 Gene

Orthologs for VTRNA1-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VTRNA1-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia Vault 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia Vault 34
  • 78 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia Vault 34
  • 56 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Vaultrc5 34
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves Vault 34
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia Vault 34
  • 57 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii Vault 34 34 34
  • 49 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea Vault 34
  • 50 (a)
OneToMany
Species where no ortholog for VTRNA1-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VTRNA1-1 Gene

ENSEMBL:
Gene Tree for VTRNA1-1 (if available)
TreeFam:
Gene Tree for VTRNA1-1 (if available)

Paralogs for VTRNA1-1 Gene

No data available for Paralogs for VTRNA1-1 Gene

Variants for VTRNA1-1 Gene

Sequence variations from dbSNP and Humsavar for VTRNA1-1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000344319 -- 140,711,731(+) A/C downstream_transcript_variant
rs1001729269 -- 140,711,271(+) C/G upstream_transcript_variant
rs1001781729 -- 140,711,063(+) C/A upstream_transcript_variant
rs1002745450 -- 140,709,623(+) A/G upstream_transcript_variant
rs1003434823 -- 140,710,744(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for VTRNA1-1 Gene

Variant ID Type Subtype PubMed ID
nsv830508 CNV loss 17160897
nsv327820 CNV deletion 16902084
esv3570455 CNV loss 25503493
esv2730831 CNV deletion 23290073

Additional Variant Information for VTRNA1-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VTRNA1-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for VTRNA1-1 Gene

Disorders for VTRNA1-1 Gene

Additional Disease Information for VTRNA1-1

No disorders were found for VTRNA1-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VTRNA1-1 Gene

Publications for VTRNA1-1 Gene

  1. Epstein-barr virus-induced expression of a novel human vault RNA. (PMID: 19298825) Nandy C … Polacek N (Journal of molecular biology 2009) 2 3 58
  2. Evolution of vault RNAs. (PMID: 19491402) Stadler PF … Ullmann K (Molecular biology and evolution 2009) 2 3 58
  3. Vaults are up-regulated in multidrug-resistant cancer cell lines. (PMID: 9535882) Kickhoefer VA … Rome LH (The Journal of biological chemistry 1998) 2 3 58
  4. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PMID: 21555518) Warnatz HJ … Yaspo ML (The Journal of biological chemistry 2011) 3 58
  5. Vaults and telomerase share a common subunit, TEP1. (PMID: 10551828) Kickhoefer VA … Rome LH (The Journal of biological chemistry 1999) 3 58

Products for VTRNA1-1 Gene

Sources for VTRNA1-1 Gene

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