The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held... See more...

Aliases for VTN Gene

Aliases for VTN Gene

  • Vitronectin 2 3 4 5
  • Serum Spreading Factor 2 3
  • Complement S-Protein 2 3
  • Somatomedin B 2 3
  • S-Protein 3 4
  • V75 3 4
  • VN 3 4
  • Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein) 2
  • Serum-Spreading Factor 4
  • Epibolin 3
  • VNT 3

External Ids for VTN Gene

Previous GeneCards Identifiers for VTN Gene

  • GC17M026549
  • GC17M028594
  • GC17M026839
  • GC17M023718
  • GC17M026692
  • GC17M026753
  • GC17M026890
  • GC17M026991
  • GC17M027137
  • GC17M028368
  • GC17M028457
  • GC17M029279
  • GC17M029379
  • GC17M028538
  • GC17M028625
  • GC17M028710
  • GC17M028806
  • GC17M028911
  • GC17M029004
  • GC17M029106
  • GC17M029189

Summaries for VTN Gene

Entrez Gene Summary for VTN Gene

  • The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]

GeneCards Summary for VTN Gene

VTN (Vitronectin) is a Protein Coding gene. Diseases associated with VTN include Glanzmann Thrombasthenia and Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome. Among its related pathways are Proteoglycans in cancer and amb2 Integrin signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and scavenger receptor activity. An important paralog of this gene is PRG4.

UniProtKB/Swiss-Prot Summary for VTN Gene

  • Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
  • Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

Gene Wiki entry for VTN Gene

Additional gene information for VTN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VTN Gene

Genomics for VTN Gene

GeneHancer (GH) Regulatory Elements for VTN Gene

Promoters and enhancers for VTN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VTN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VTN gene promoter:
  • ARP-1
  • ATF
  • GATA-2
  • HTF
  • LyF-1
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • p300

Genomic Locations for VTN Gene

Genomic Locations for VTN Gene
chr17:28,367,277-28,373,091
(GRCh38/hg38)
Size:
5,815 bases
Orientation:
Minus strand
chr17:26,691,290-26,700,110
(GRCh37/hg19)
Size:
8,821 bases
Orientation:
Minus strand

Genomic View for VTN Gene

Genes around VTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTN Gene

Proteins for VTN Gene

  • Protein details for VTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04004-VTNC_HUMAN
    Recommended name:
    Vitronectin
    Protein Accession:
    P04004
    Secondary Accessions:
    • B2R7G0
    • P01141
    • Q9BSH7

    Protein attributes for VTN Gene

    Size:
    478 amino acids
    Molecular mass:
    54306 Da
    Quaternary structure:
    • Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and C1QBP.

    Three dimensional structures from OCA and Proteopedia for VTN Gene

neXtProt entry for VTN Gene

Post-translational modifications for VTN Gene

  • Sulfated on 2 tyrosine residues.
  • N- and O-glycosylated.
  • Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • Phosphorylation sites are present in the extracellular medium.
  • Glycosylation at Asn86, Asn169, and Asn242
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • VTNC_HUMAN (625)

Other Protein References for VTN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VTN Gene

Domains & Families for VTN Gene

Gene Families for VTN Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for VTN Gene

GenScript: Design optimal peptide antigens:
  • Vitronectin (D9ZGG2_HUMAN)
  • V75 (VTNC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04004

UniProtKB/Swiss-Prot:

VTNC_HUMAN :
  • The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
Domain:
  • The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
genes like me logo Genes that share domains with VTN: view

Function for VTN Gene

Molecular function for VTN Gene

UniProtKB/Swiss-Prot Function:
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
UniProtKB/Swiss-Prot Function:
Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
GENATLAS Biochemistry:
vitronectin,complement S protein (75kDa),precursor of 65 and 10kDa chains

Phenotypes From GWAS Catalog for VTN Gene

Gene Ontology (GO) - Molecular Function for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005178 integrin binding IPI 8837777
GO:0005201 extracellular matrix structural constituent RCA 20551380
GO:0005515 protein binding IPI 8900153
GO:0005518 collagen binding IEA --
genes like me logo Genes that share ontologies with VTN: view
genes like me logo Genes that share phenotypes with VTN: view

Animal Models for VTN Gene

MGI Knock Outs for VTN:
  • Vtn Vtn<tm1Dgi>

Animal Model Products

CRISPR Products

miRNA for VTN Gene

miRTarBase miRNAs that target VTN

Clone Products

  • Addgene plasmids for VTN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VTN Gene

Localization for VTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VTN Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VTN gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 4
cytoskeleton 2
golgi apparatus 2
nucleus 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,HDA --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space TAS,IDA 1695900
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with VTN: view

Pathways & Interactions for VTN Gene

genes like me logo Genes that share pathways with VTN: view

SIGNOR curated interactions for VTN Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006955 immune response IEA --
GO:0007155 cell adhesion TAS 2418831
GO:0007160 cell-matrix adhesion IDA,IGI 22505472
GO:0008283 cell proliferation IGI 22505472
genes like me logo Genes that share ontologies with VTN: view

Drugs & Compounds for VTN Gene

(42) Drugs for VTN Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abciximab Approved Pharma Target 66
Copper Approved, Investigational Pharma Target 227
Zinc Approved, Investigational Pharma Target 2741
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0

(68) Additional Compounds for VTN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VTN: view

Transcripts for VTN Gene

mRNA/cDNA for VTN Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(411) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for VTN

Alternative Splicing Database (ASD) splice patterns (SP) for VTN Gene

No ASD Table

Relevant External Links for VTN Gene

GeneLoc Exon Structure for
VTN
ECgene alternative splicing isoforms for
VTN

Expression for VTN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VTN Gene

This gene is overexpressed in Serum (22.2), Synovial fluid (10.6), and Plasma (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VTN Gene



Protein tissue co-expression partners for VTN Gene

NURSA nuclear receptor signaling pathways regulating expression of VTN Gene:

VTN

SOURCE GeneReport for Unigene cluster for VTN Gene:

Hs.2257

mRNA Expression by UniProt/SwissProt for VTN Gene:

P04004-VTNC_HUMAN
Tissue specificity: Plasma.

Evidence on tissue expression from TISSUES for VTN Gene

  • Blood(4.5)
  • Lung(4.4)
  • Bone marrow(4.3)
  • Liver(4.3)
  • Nervous system(4.3)
  • Heart(2.4)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with VTN: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for VTN Gene

Orthologs for VTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for VTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VTN 33 32
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia VTN 33 32
  • 82.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia VTN 33 32
  • 80.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Vtn 17 33 32
  • 79.38 (n)
rat
(Rattus norvegicus)
Mammalia Vtn 32
  • 77.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VTN 33
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VTN 33
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves VTN 33 32
  • 64.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VTN 33
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vtn 32
  • 60.67 (n)
Str.15366 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.9844 32
zebrafish
(Danio rerio)
Actinopterygii vtnb 33 32
  • 55.89 (n)
OneToMany
vtna 33
  • 41 (a)
OneToMany
Dr.13466 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11199 32
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 32 (a)
OneToMany
Species where no ortholog for VTN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VTN Gene

ENSEMBL:
Gene Tree for VTN (if available)
TreeFam:
Gene Tree for VTN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VTN: view image

Paralogs for VTN Gene

Paralogs for VTN Gene

(3) SIMAP similar genes for VTN Gene using alignment to 4 proteins:

  • VTNC_HUMAN
  • C9JDG5_HUMAN
  • D9ZGG2_HUMAN
  • F5GX75_HUMAN
genes like me logo Genes that share paralogs with VTN: view

Variants for VTN Gene

Sequence variations from dbSNP and Humsavar for VTN Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1002456899 -- 28,371,700(-) C/T upstream_transcript_variant
rs1004386282 -- 28,371,746(-) G/T upstream_transcript_variant
rs1006705877 -- 28,367,717(-) C/G coding_sequence_variant, missense_variant
rs1009074725 -- 28,368,761(-) A/G intron_variant
rs1010856225 -- 28,366,930(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for VTN Gene

Variant ID Type Subtype PubMed ID
nsv1056839 CNV gain 25217958
nsv519388 CNV loss 19592680
nsv574653 CNV gain 21841781

Variation tolerance for VTN Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VTN Gene

Human Gene Mutation Database (HGMD)
VTN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VTN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VTN Gene

Disorders for VTN Gene

MalaCards: The human disease database

(20) MalaCards diseases for VTN Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search VTN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VTN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with VTN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VTN Gene

Publications for VTN Gene

  1. Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading. (PMID: 9733784) Seger D … Shaltiel S (The Journal of biological chemistry 1998) 3 4 23 56
  2. The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor. (PMID: 8900153) Lim BL … Preissner KT (The Journal of biological chemistry 1996) 3 4 23 56
  3. Identification of a PAI-1 binding site in vitronectin. (PMID: 7522053) Sigurdardottir O … Wiman B (Biochimica et biophysica acta 1994) 3 4 23 56
  4. Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. (PMID: 1704366) Seiffert D … Loskutoff DJ (The Journal of biological chemistry 1991) 3 4 23 56
  5. The phosphorylation of the two-chain form of vitronectin by protein kinase A is heparin dependent. (PMID: 1696913) Chain D … Shaltiel S (FEBS letters 1990) 3 4 23 56

Products for VTN Gene

  • Addgene plasmids for VTN

Sources for VTN Gene