Aliases for VTN Gene
External Ids for VTN Gene
Previous GeneCards Identifiers for VTN Gene
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
GeneCards Summary for VTN Gene
VTN (Vitronectin) is a Protein Coding gene. Diseases associated with VTN include Glanzmann Thrombasthenia and Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome. Among its related pathways are Immune response Lectin induced complement pathway and Cell adhesion_Endothelial cell contacts by non-junctional mechanisms. Gene Ontology (GO) annotations related to this gene include heparin binding and scavenger receptor activity. An important paralog of this gene is PRG4.
UniProtKB/Swiss-Prot Summary for VTN Gene
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.