The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein ca... See more...

Aliases for VTN Gene

Aliases for VTN Gene

  • Vitronectin 2 3 4 5
  • VN 2 3 4
  • Serum Spreading Factor 2 3
  • Complement S-Protein 2 3
  • Somatomedin B 2 3
  • V75 3 4
  • Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein) 2
  • Serum-Spreading Factor 4
  • S-Protein 4
  • Epibolin 3
  • VNT 3
  • VTN 5

External Ids for VTN Gene

Previous GeneCards Identifiers for VTN Gene

  • GC17M026549
  • GC17M028594
  • GC17M026839
  • GC17M023718
  • GC17M026692
  • GC17M026753
  • GC17M026890
  • GC17M026991
  • GC17M027137
  • GC17M028368
  • GC17M028457
  • GC17M029279
  • GC17M029379
  • GC17M029401
  • GC17M029696
  • GC17M028538
  • GC17M028625
  • GC17M028710
  • GC17M028806
  • GC17M028911
  • GC17M029004
  • GC17M029106
  • GC17M029189
  • GC17M029955
  • GC17M030247

Summaries for VTN Gene

Entrez Gene Summary for VTN Gene

  • The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]

GeneCards Summary for VTN Gene

VTN (Vitronectin) is a Protein Coding gene. Diseases associated with VTN include Glanzmann Thrombasthenia and Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome. Among its related pathways are MET promotes cell motility and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include heparin binding and scavenger receptor activity. An important paralog of this gene is PRG4.

UniProtKB/Swiss-Prot Summary for VTN Gene

  • Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
  • Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

Gene Wiki entry for VTN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VTN Gene

Genomics for VTN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for VTN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VTN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VTN

Top Transcription factor binding sites by QIAGEN in the VTN gene promoter:
  • ARP-1
  • ATF
  • GATA-2
  • HTF
  • LyF-1
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • p300

Genomic Locations for VTN Gene

Latest Assembly
chr17:28,367,284-28,373,091
(GRCh38/hg38)
Size:
5,808 bases
Orientation:
Minus strand

Previous Assembly
chr17:26,694,305-26,697,328
(GRCh37/hg19 by Entrez Gene)
Size:
3,024 bases
Orientation:
Minus strand

chr17:26,691,290-26,700,110
(GRCh37/hg19 by Ensembl)
Size:
8,821 bases
Orientation:
Minus strand

Genomic View for VTN Gene

Genes around VTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTN Gene

Proteins for VTN Gene

  • Protein details for VTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04004-VTNC_HUMAN
    Recommended name:
    Vitronectin
    Protein Accession:
    P04004
    Secondary Accessions:
    • B2R7G0
    • P01141
    • Q9BSH7

    Protein attributes for VTN Gene

    Size:
    478 amino acids
    Molecular mass:
    54306 Da
    Quaternary structure:
    • Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and C1QBP.
    • (Microbial infection) Interacts (via hemopexin repeat 2) with P.falciparum (isolate CDC / Honduras) SERA5 P47 (via C-terminus); may form heterotetramers of two VTN and SERA5 P47 heterodimers; the interaction may protect merozoites from phagocytosis by host monocytes; VTN glycosylation appears to be dispensable for the interaction.

    Three dimensional structures from OCA and Proteopedia for VTN Gene

neXtProt entry for VTN Gene

Post-translational modifications for VTN Gene

  • Sulfated on tyrosine residues.
  • N- and O-glycosylated.
  • Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • Phosphorylation sites are present in the extracellular medium.
  • Glycosylation at Asn86, Asn169, and Asn242
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • VTNC_HUMAN (625)

Other Protein References for VTN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for VTN Gene

Domains & Families for VTN Gene

Gene Families for VTN Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for VTN Gene

GenScript: Design optimal peptide antigens:
  • Vitronectin (D9ZGG2_HUMAN)
  • V75 (VTNC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04004

UniProtKB/Swiss-Prot:

VTNC_HUMAN :
  • The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
Domain:
  • The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
genes like me logo Genes that share domains with VTN: view

Function for VTN Gene

Molecular function for VTN Gene

UniProtKB/Swiss-Prot Function:
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
UniProtKB/Swiss-Prot Function:
Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
GENATLAS Biochemistry:
vitronectin,complement S protein (75kDa),precursor of 65 and 10kDa chains

Phenotypes From GWAS Catalog for VTN Gene

Gene Ontology (GO) - Molecular Function for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005178 integrin binding IPI 8837777
GO:0005201 extracellular matrix structural constituent RCA 20551380
GO:0005515 protein binding IPI 8900153
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with VTN: view
genes like me logo Genes that share phenotypes with VTN: view

Animal Models for VTN Gene

MGI Knock Outs for VTN:
  • Vtn Vtn<tm1Dgi>

miRNA for VTN Gene

miRTarBase miRNAs that target VTN

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VTN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VTN Gene

Localization for VTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VTN Gene

Secreted, extracellular space.
Parasitophorous vacuole. Note=(Microbial infection) In P.falciparum-infected red blood cells, VTN internalization is detected at the early trophozoite stage (PubMed:29567995). Colocalizes with SERA5 at the schizont stage and with SERA5 P47 at the merozoite surface (PubMed:29567995). {ECO:0000269 PubMed:29567995}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VTN gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 4
cytoskeleton 3
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space TAS,IDA 1695900
GO:0005783 endoplasmic reticulum IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0062023 colocalizes_with collagen-containing extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with VTN: view

Pathways & Interactions for VTN Gene

genes like me logo Genes that share pathways with VTN: view

Pathways by source for VTN Gene

5 GeneGo (Thomson Reuters) pathways for VTN Gene
  • Cell adhesion PLAU signaling
  • Cell adhesion_ECM remodeling
  • Cell adhesion_Endothelial cell contacts by non-junctional mechanisms
  • Cytoskeleton remodeling Integrin outside-in signaling
  • Development VEGF-family signaling
3 Qiagen pathways for VTN Gene
  • Glioma Invasiveness
  • Phagocytosis of Microbes
  • UPA-UPAR Pathway

SIGNOR curated interactions for VTN Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006955 immune response IEA --
GO:0007155 cell adhesion TAS 2418831
GO:0007160 cell-matrix adhesion IDA,IGI 22505472
GO:0010951 negative regulation of endopeptidase activity IDA 1695900
genes like me logo Genes that share ontologies with VTN: view

Drugs & Compounds for VTN Gene

(43) Drugs for VTN Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abciximab Approved Pharma Target 66
Copper Approved, Investigational Pharma Target 276
Zinc Approved, Investigational Pharma Target 1706
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target, inducer 0

(68) Additional Compounds for VTN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VTN: view

Transcripts for VTN Gene

mRNA/cDNA for VTN Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VTN

Alternative Splicing Database (ASD) splice patterns (SP) for VTN Gene

No ASD Table

Relevant External Links for VTN Gene

GeneLoc Exon Structure for
VTN

Expression for VTN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VTN Gene

This gene is overexpressed in Serum (22.2), Synovial fluid (10.6), and Plasma (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VTN Gene



Protein tissue co-expression partners for VTN Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VTN

SOURCE GeneReport for Unigene cluster for VTN Gene:

Hs.2257

mRNA Expression by UniProt/SwissProt for VTN Gene:

P04004-VTNC_HUMAN
Tissue specificity: Expressed in the retina pigment epithelium (at protein level) (PubMed:25136834). Expressed in plasma (at protein level) (PubMed:2448300). Expressed in serum (at protein level) (PubMed:29567995).

Evidence on tissue expression from TISSUES for VTN Gene

  • Blood(4.5)
  • Nervous system(4.5)
  • Liver(4.4)
  • Bone marrow(4.4)
  • Lung(4.4)
  • Heart(3.2)
  • Bone(2.4)
  • Skin(2.3)
  • Muscle(2.3)
  • Eye(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with VTN: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for VTN Gene

Orthologs for VTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for VTN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia VTN 29 30
  • 99.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia VTN 29 30
  • 82.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia VTN 29 30
  • 80.71 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Vtn 29 16 30
  • 79.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Vtn 29
  • 77.01 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia VTN 30
  • 68 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia VTN 30
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves VTN 29 30
  • 64.95 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia VTN 30
  • 51 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia vtn 29
  • 60.67 (n)
Str.15366 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.9844 29
Zebrafish
(Danio rerio)
Actinopterygii vtnb 29 30
  • 55.89 (n)
OneToMany
vtna 30
  • 41 (a)
OneToMany
Dr.13466 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11199 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 32 (a)
OneToMany
Species where no ortholog for VTN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for VTN Gene

ENSEMBL:
Gene Tree for VTN (if available)
TreeFam:
Gene Tree for VTN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VTN: view image
Alliance of Genome Resources:
Additional Orthologs for VTN

Paralogs for VTN Gene

Paralogs for VTN Gene

(3) SIMAP similar genes for VTN Gene using alignment to 4 proteins:

  • VTNC_HUMAN
  • C9JDG5_HUMAN
  • D9ZGG2_HUMAN
  • F5GX75_HUMAN
genes like me logo Genes that share paralogs with VTN: view

Variants for VTN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VTN Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs111490653 Benign: not provided 28,369,988(-) G/A
NM_000638.4(VTN):c.123C>T (p.Asp41=)
SYNONYMOUS
rs112887300 Benign: not provided 28,369,659(-) T/A
NM_000638.4(VTN):c.377A>T (p.Glu126Val)
MISSENSE
rs145861745 Likely Benign: not provided 28,370,012(-) G/A
NM_000638.4(VTN):c.99C>T (p.Asn33=)
SYNONYMOUS
rs150241335 Likely Benign: not provided 28,367,411(-) G/A
NM_000638.4(VTN):c.1395C>T (p.Ile465=)
SYNONYMOUS
rs34134929 Benign: not provided 28,368,609(-) G/A
NM_000638.4(VTN):c.891C>T (p.Ser297=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for VTN Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for VTN Gene

Variant ID Type Subtype PubMed ID
nsv1056839 CNV gain 25217958
nsv519388 CNV loss 19592680
nsv574653 CNV gain 21841781

Variation tolerance for VTN Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VTN Gene

Human Gene Mutation Database (HGMD)
VTN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VTN
Leiden Open Variation Database (LOVD)
VTN

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VTN Gene

Disorders for VTN Gene

MalaCards: The human disease database

(36) MalaCards diseases for VTN Gene - From: COP and GCD

Disorder Aliases PubMed IDs
glanzmann thrombasthenia
  • gt
camptodactyly-arthropathy-coxa vara-pericarditis syndrome
  • cacp
hypermobility syndrome
  • benign joint hypermobility
membranous nephropathy
  • membranous nephropathy, susceptibility to
haemophilus influenzae
  • h. influenzae
- elite association - COSMIC cancer census association via MalaCards
Search VTN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VTN

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with VTN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VTN Gene

Publications for VTN Gene

  1. How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration. (PMID: 12808446) Zhou A … Read RJ (Nature structural biology 2003) 3 4 22
  2. Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading. (PMID: 9733784) Seger D … Shaltiel S (The Journal of biological chemistry 1998) 3 4 22
  3. The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor. (PMID: 8900153) Lim BL … Preissner KT (The Journal of biological chemistry 1996) 3 4 22
  4. Identification of a PAI-1 binding site in vitronectin. (PMID: 7522053) Sigurdardottir O … Wiman B (Biochimica et biophysica acta 1994) 3 4 22
  5. Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. (PMID: 1704366) Seiffert D … Loskutoff DJ (The Journal of biological chemistry 1991) 3 4 22

Products for VTN Gene

  • Addgene plasmids for VTN

Sources for VTN Gene