Aliases for VTN Gene
External Ids for VTN Gene
Previous GeneCards Identifiers for VTN Gene
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
GeneCards Summary for VTN Gene
VTN (Vitronectin) is a Protein Coding gene. Diseases associated with VTN include Glanzmann Thrombasthenia and Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome. Among its related pathways are Degradation of the extracellular matrix and amb2 Integrin signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and scavenger receptor activity. An important paralog of this gene is PRG4.
UniProtKB/Swiss-Prot Summary for VTN Gene
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.