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This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1) is a Protein Coding gene. Diseases associated with VTCN1 include Ovarian Cancer. Among its related pathways are Cell adhesion molecules and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is BTN3A3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0005102 | signaling receptor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0009897 | external side of plasma membrane | IDA | 16606666 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | NF-kappaB Signaling | ||
2 | Cell adhesion molecules |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001562 | response to protozoan | IEA | -- |
GO:0001817 | regulation of cytokine production | IBA | 21873635 |
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0032743 | positive regulation of interleukin-2 production | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||
SP4: | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | VTCN1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | VTCN1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | VTCN1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | VTCN1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Vtcn1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Vtcn1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | VTCN1 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | vtcn1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-174k18.6 30 |
|
||
VTCN1 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2716640 | CNV | deletion | 23290073 |
nsv1007386 | CNV | loss | 25217958 |
nsv1009706 | CNV | gain | 25217958 |
nsv1145363 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian cancer |
|
|