Aliases for VSTM2L Gene
Aliases for VSTM2L Gene
External Ids for VSTM2L Gene
- HGNC: 16096
- Entrez Gene: 128434
- Ensembl: ENSG00000132821
- OMIM: 616537
- UniProtKB: Q96N03
Previous HGNC Symbols for VSTM2L Gene
- C20orf102
Previous GeneCards Identifiers for VSTM2L Gene
- GC20P035965
- GC20P036531
- GC20P033266
Summaries for VSTM2L Gene
GeneCards Summary for VSTM2L Gene
VSTM2L (V-Set And Transmembrane Domain Containing 2 Like) is a Protein Coding gene. An important paralog of this gene is BSG.
Additional gene information for VSTM2L Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSTM2L Gene
Genomics for VSTM2L Gene
GeneHancer (GH) Regulatory Elements for VSTM2L Gene
Promoters and enhancers for VSTM2L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around VSTM2L on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the VSTM2L gene promoter:
-
- AhR
- AML1a
- CUTL1
- NRF-2
- p53
- Spz1
- STAT1
- STAT1alpha
- STAT1beta
- TGIF
Genomic Locations for VSTM2L Gene
Genomic Locations for VSTM2L Gene
- chr20:37,903,097-37,945,350
- (GRCh38/hg38)
- Size:
- 42,254 bases
- Orientation:
- Plus strand
- chr20:36,531,499-36,573,752
- (GRCh37/hg19)
- Size:
- 42,254 bases
- Orientation:
- Plus strand
Genomic View for VSTM2L Gene
Genes around VSTM2L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by HGNC
- 20q11.23 by Entrez Gene
- 20q11.23 by Ensembl
VSTM2L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VSTM2L Gene
Proteins for VSTM2L Gene
-
Protein details for VSTM2L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96N03-VTM2L_HUMAN
- Recommended name:
- V-set and transmembrane domain-containing protein 2-like protein
- Protein Accession:
- Q96N03
- E1P5V7
- Q5JWZ4
- Q5JWZ5
- Q8ND45
- Q9BR37
Protein attributes for VSTM2L Gene
- Size:
- 204 amino acids
- Molecular mass:
- 22349 Da
- Quaternary structure:
- No Data Available
Protein Expression for VSTM2L Gene
Post-translational modifications for VSTM2L Gene
Other Protein References for VSTM2L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-VSTM2L Antibody
- Novus Biologicals Antibodies for VSTM2L
-
Abcam antibodies for VSTM2L
- Invitrogen Antibodies for VSTM2L (AFLGC-VSTM2L)
-
Santa Cruz Biotechnology (SCBT) Antibodies for VSTM2L
Protein Products
- Atlas Antibodies PrEST Antigen VSTM2L
-
OriGene Purified Proteins for VSTM2L
- Search Origene for MassSpec and Protein Over-expression Lysates for VSTM2L
- Origene Custom Protein Services for VSTM2L
- ProSpec Recombinant Proteins for VSTM2L
-
Abcam proteins for VSTM2L
No data available for DME Specific Peptides for VSTM2L Gene
Domains & Families for VSTM2L Gene
Gene Families for VSTM2L Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for VSTM2L Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for VSTM2L Gene
- GenScript: Design optimal peptide antigens:
-
- V-set and transmembrane domain-containing protein 2-like protein (VTM2L_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for VSTM2L Gene
Function for VSTM2L Gene
Phenotypes From GWAS Catalog for VSTM2L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16713569 |
| GO:0098632 | cell-cell adhesion mediator activity | IBA | 21873635 |
Phenotypes for VSTM2L Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for VSTM2L
- Cyagen custom Knockout/knockin (KOKI) mouse models for VSTM2L
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VSTM2L - Now 50% OFF >
- * VSTM2L CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * VSTM2L CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for VSTM2L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VSTM2L
- genomics-online: gRNA clones - Search results for 76 available VSTM2L gene related products
- Overview of 76 available VSTM2L gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for VSTM2L
miRNA for VSTM2L Gene
- miRTarBase miRNAs that target VSTM2L
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for VSTM2L
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- genomics-online: shRNA clones - Search results for 76 available VSTM2L gene related products
- Overview of 76 available VSTM2L gene related products
Clone Products
- Applied Biological Materials (abm): Clones for VSTM2L - Now 50% OFF >
- * VSTM2L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * VSTM2L tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for VSTM2L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VSTM2L
Cell Line Products
-
Horizon Cell Lines for VSTM2L
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VSTM2L Gene
Localization for VSTM2L Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| nucleus | 2 |
| cytoskeleton | 1 |
| lysosome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA | 21393573 |
| GO:0005737 | cytoplasm | IDA | 21393573 |
| GO:0005886 | plasma membrane | IBA | 21873635 |
| GO:0030424 | axon | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for VSTM2L Gene
Pathways & Interactions for VSTM2L Gene
Interacting Proteins for VSTM2L Gene
Selected Interacting proteins:
Q96N03-VTM2L_HUMAN
ENSP00000362560
for VSTM2L Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for VSTM2L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | IBA | 21873635 |
| GO:0007411 | axon guidance | IBA | 21873635 |
| GO:0043524 | negative regulation of neuron apoptotic process | IDA | 21393573 |
| GO:0070593 | dendrite self-avoidance | IBA | 21873635 |
No data available for Pathways by source and SIGNOR curated interactions for VSTM2L Gene
Drugs & Compounds for VSTM2L Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen VSTM2L
Transcripts for VSTM2L Gene
mRNA/cDNA for VSTM2L Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (108) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000373461 1936 bps (ENST00000373461.8)
- ENST00000373459 831 bps (ENST00000373459.4)
- ENST00000448944 656 bps (ENST00000448944.1)
Unigene Clusters for VSTM2L Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for VSTM2L - Now 50% OFF >
- * VSTM2L CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * VSTM2L CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for VSTM2L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for VSTM2L
- genomics-online: gRNA clones - Search results for 76 available VSTM2L gene related products
- Overview of 76 available VSTM2L gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for VSTM2L
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for VSTM2L
- Browse OriGene Inhibitory RNA Products For VSTM2L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VSTM2L
- genomics-online: shRNA clones - Search results for 76 available VSTM2L gene related products
- Overview of 76 available VSTM2L gene related products
Clone Products
- Applied Biological Materials (abm): Clones for VSTM2L - Now 50% OFF >
- * VSTM2L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * VSTM2L tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for VSTM2L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for VSTM2L
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||
| SP5: | - | - | - | - | - |
Expression for VSTM2L Gene
mRNA differential expression in normal tissues according to GTEx for VSTM2L Gene
This gene is overexpressed in Brain - Cortex (x6.6), Brain - Frontal Cortex (BA9) (x5.4), Heart - Atrial Appendage (x5.0), Brain - Hippocampus (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.6), and Brain - Amygdala (x4.4).
This gene is overexpressed in Liver (68.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VSTM2L Gene
NURSA nuclear receptor signaling pathways regulating expression of VSTM2L Gene:
VSTM2LSOURCE GeneReport for Unigene cluster for VSTM2L Gene:
Hs.517029Evidence on tissue expression from TISSUES for VSTM2L Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for VSTM2L
-
OriGene qPCR primer pairs and template standards for VSTM2L
- genomics-online: primer clones - Search results for 76 available VSTM2L gene related products
- Overview of 76 available VSTM2L gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSTM2L Gene
Orthologs for VSTM2L Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VSTM2L 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | VSTM2L 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | VSTM2L 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | RGD1305725 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Vstm2l 17 35 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | VSTM2L 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | VSTM2L 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | VSTM2L 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | vstm2l 34 |
|
||
| Str.19138 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | vstm2l 35 34 |
|
OneToOne | |
| zgc66133 34 |
|
- Species where no ortholog for VSTM2L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for VSTM2L Gene
- ENSEMBL:
- Gene Tree for VSTM2L (if available)
- TreeFam:
- Gene Tree for VSTM2L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for VSTM2L: view image
Paralogs for VSTM2L Gene
Variants for VSTM2L Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021314 | -- | 37,930,179(+) | T/G | intron_variant | |
| rs1000069252 | -- | 37,925,238(+) | C/T | intron_variant | |
| rs1000069386 | -- | 37,924,918(+) | G/A | intron_variant | |
| rs1000113197 | -- | 37,902,669(+) | C/G | upstream_transcript_variant | |
| rs1000166926 | -- | 37,902,313(+) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2633566 | CNV | insertion | 19546169 |
| nsv1057334 | CNV | loss | 25217958 |
| nsv1066778 | CNV | gain | 25217958 |
| nsv833970 | CNV | gain | 17160897 |
| nsv833971 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.57;
65.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VSTM2L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VSTM2L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSTM2L Gene
Disorders for VSTM2L Gene
Additional Disease Information for VSTM2L
No disorders were found for VSTM2L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSTM2L Gene
Publications for VSTM2L Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
- Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58
- Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
ExternalLinks
Products for VSTM2L Gene
- Browse OriGene Antibodies
- Custom Antibody Services
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- Custom Assay Services
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- OriGene qPCR primer pairs for VSTM2L
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Taconic Biosciences Mouse Models for VSTM2L
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
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- antibodies-online: Search results for available VSTM2L related products ranked by validation data
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- Overview of 76 available VSTM2L gene related products
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Sources for VSTM2L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
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- (91) HOMER
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- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
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- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
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- (131) ENCODE
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- (133) Horizon
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- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind