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Aliases for VSIR Gene

Aliases for VSIR Gene

  • V-Set Immunoregulatory Receptor 2 3 4 5
  • V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation 3 4
  • V-Set Domain-Containing Immunoregulatory Receptor 3 4
  • V-Domain Ig Suppressor Of T Cell Activation 2 3
  • Stress-Induced Secreted Protein-1 3 4
  • PDCD1 Homolog 2 3
  • C10orf54 3 4
  • Sisp-1 3 4
  • SISP1 3 4
  • VISTA 3 4
  • Chromosome 10 Open Reading Frame 54 2
  • Stress Induced Secreted Protein 1 2
  • Platelet Receptor GI24 3
  • Platelet Receptor Gi24 4
  • Death Domain1alpha 3
  • DD1alpha 3
  • PP2135 3
  • B7-H5 3
  • Dies1 3
  • PD-1H 3
  • B7H5 3
  • GI24 3

External Ids for VSIR Gene

Previous HGNC Symbols for VSIR Gene

  • C10orf54

Summaries for VSIR Gene

GeneCards Summary for VSIR Gene

VSIR (V-Set Immunoregulatory Receptor) is a Protein Coding gene. Diseases associated with VSIR include Parasagittal Meningioma and Cerebral Convexity Meningioma. Among its related pathways are NF-kappaB Signaling and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. An important paralog of this gene is ESAM.

UniProtKB/Swiss-Prot for VSIR Gene

  • Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).

Gene Wiki entry for VSIR Gene

Additional gene information for VSIR Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIR Gene

Genomics for VSIR Gene

GeneHancer (GH) Regulatory Elements for VSIR Gene

Promoters and enhancers for VSIR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J071762 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 653.5 +3.6 3590 14.1 SP1 ZFX CBFA2T2 NKRF GTF2F1 ZNF687 ZNF24 MAFK SP7 ELF1 VSIR CDH23 C10orf105 PSAP SPOCK2
GH10J071726 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 45.7 +45.9 45892 4.3 SP1 ZFX CTCF ZNF121 ZNF687 TRIM24 SP7 ZNF639 EGR1 IKZF1 VSIR CDH23 C10orf105 PSAP GC10P071695
GH10J071844 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.9 -75.3 -75309 8.2 CC2D1A MNT CBFA2T2 ZNF148 POLR2A MLLT1 ZNF121 RERE GTF2F1 ZNF687 PSAP VSIR C10orf105 ANAPC16 MICU1 DDIT4 RNU7-38P
GH10J071745 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.5 +21.1 21104 14.7 SP1 ZFX CC2D1A ZKSCAN8 CBFA2T2 ZNF148 CEBPG ZNF687 BACH1 MAFK DNAJB12 VSIR CDH23 C10orf105
GH10J071712 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 16.9 +59.3 59275 5 ZFX ZKSCAN8 ZNF148 ZNF639 IKZF1 ATF1 ZNF740 POLR2A MTA3 ZBTB11 VSIR DNAJB12 CDH23 GC10P071695 C10orf105
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VSIR on UCSC Golden Path with GeneCards custom track

Genomic Locations for VSIR Gene

Genomic Locations for VSIR Gene
chr10:71,747,556-71,773,580
(GRCh38/hg38)
Size:
26,025 bases
Orientation:
Minus strand
chr10:73,507,313-73,533,337
(GRCh37/hg19)
Size:
26,025 bases
Orientation:
Minus strand

Genomic View for VSIR Gene

Genes around VSIR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIR Gene

Proteins for VSIR Gene

  • Protein details for VSIR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7M9-VISTA_HUMAN
    Recommended name:
    V-type immunoglobulin domain-containing suppressor of T-cell activation
    Protein Accession:
    Q9H7M9
    Secondary Accessions:
    • A1L0X9
    • A4ZYV1
    • A8MVH5
    • Q6UXF3
    • Q8WUG3
    • Q8WYZ8

    Protein attributes for VSIR Gene

    Size:
    311 amino acids
    Molecular mass:
    33908 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL55778.1; Type=Erroneous termination; Positions=84; Note=Translated as Ser.; Evidence={ECO:0000305}; Sequence=AAL55778.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAB15739.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for VSIR Gene

Post-translational modifications for VSIR Gene

Other Protein References for VSIR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSIR Gene

Domains & Families for VSIR Gene

Gene Families for VSIR Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for VSIR Gene

Suggested Antigen Peptide Sequences for VSIR Gene

GenScript: Design optimal peptide antigens:
  • C10orf54 protein (A1L0X9_HUMAN)
  • Stress induced secreted protein 1 (A4ZYV1_HUMAN)
  • Platelet receptor Gi24 (GI24_HUMAN)
  • C10orf54 protein (Q2TA85_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VSIR: view

No data available for UniProtKB/Swiss-Prot for VSIR Gene

Function for VSIR Gene

Molecular function for VSIR Gene

UniProtKB/Swiss-Prot Function:
Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).

Phenotypes From GWAS Catalog for VSIR Gene

Gene Ontology (GO) - Molecular Function for VSIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 20666777
GO:0042802 identical protein binding IPI 26228159
GO:0061133 endopeptidase activator activity IDA 20666777
genes like me logo Genes that share ontologies with VSIR: view
genes like me logo Genes that share phenotypes with VSIR: view

Animal Models for VSIR Gene

MGI Knock Outs for VSIR:
  • Vsir Vsir<tm1Lex>
  • Vsir Vsir<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for VSIR

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VSIR

Clone Products

  • Applied Biological Materials (abm): Clones for VSIR - Now 50% OFF >
  • * VSIR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * VSIR tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VSIR Gene

Localization for VSIR Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIR Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSIR gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
mitochondrion 1
cytosol 1
endoplasmic reticulum 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VSIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 20666777
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIR: view

Pathways & Interactions for VSIR Gene

genes like me logo Genes that share pathways with VSIR: view

Pathways by source for VSIR Gene

1 KEGG pathway for VSIR Gene
1 R&D Systems pathway for VSIR Gene
1 Cell Signaling Technology pathway for VSIR Gene

Gene Ontology (GO) - Biological Process for VSIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IMP 20666777
GO:0010950 positive regulation of endopeptidase activity IDA 20666777
GO:0030335 positive regulation of cell migration IDA 20666777
GO:0031638 zymogen activation IDA 20666777
GO:0032689 negative regulation of interferon-gamma production IDA 24691993
genes like me logo Genes that share ontologies with VSIR: view

No data available for SIGNOR curated interactions for VSIR Gene

Transcripts for VSIR Gene

mRNA/cDNA for VSIR Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VSIR

Clone Products

  • Applied Biological Materials (abm): Clones for VSIR - Now 50% OFF >
  • * VSIR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * VSIR tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for VSIR Gene

No ASD Table

Relevant External Links for VSIR Gene

GeneLoc Exon Structure for
VSIR
ECgene alternative splicing isoforms for
VSIR

Expression for VSIR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of VSIR Gene:

VSIR

mRNA Expression by UniProt/SwissProt for VSIR Gene:

Q9H7M9-VISTA_HUMAN
Tissue specificity: Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues.

Evidence on tissue expression from TISSUES for VSIR Gene

  • Liver(4.7)
  • Nervous system(4.6)
  • Blood(4.5)
  • Spleen(4.4)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with VSIR: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSIR Gene

Orthologs for VSIR Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf54 34
  • 99.36 (n)
C10orf54 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C28H10orf54 34
  • 86.99 (n)
MGC151567 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10orf54 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4632428N05Rik 35 34
  • 79.65 (n)
OneToOne
Vsir 17
rat
(Rattus norvegicus)
Mammalia MGC112715 34
  • 77.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf54 35
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C10orf54 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10ORF54 34
  • 64.81 (n)
C10orf54 35
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C10orf54 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf54 34
  • 57.5 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:153073 34
  • 52.12 (n)
C13H10orf54 35
  • 38 (a)
OneToOne
Species where no ortholog for VSIR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSIR Gene

ENSEMBL:
Gene Tree for VSIR (if available)
TreeFam:
Gene Tree for VSIR (if available)

Paralogs for VSIR Gene

genes like me logo Genes that share paralogs with VSIR: view

Variants for VSIR Gene

Sequence variations from dbSNP and Humsavar for VSIR Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000365134 -- 71,767,466(-) T/C intron_variant
rs1000491513 -- 71,772,674(-) T/C intron_variant
rs1000696419 -- 71,768,664(-) G/A intron_variant
rs1000711085 -- 71,774,277(-) T/C upstream_transcript_variant
rs1000748766 -- 71,769,027(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VSIR Gene

Variant ID Type Subtype PubMed ID
esv1096295 CNV deletion 17803354
nsv1127122 CNV deletion 24896259
nsv1137935 CNV deletion 24896259
nsv1147297 CNV deletion 26484159
nsv470963 CNV loss 18288195
nsv831910 CNV loss 17160897

Variation tolerance for VSIR Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.55; 86.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VSIR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VSIR
Human Gene Mutation Database (HGMD)
VSIR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSIR Gene

Disorders for VSIR Gene

MalaCards: The human disease database

(7) MalaCards diseases for VSIR Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
parasagittal meningioma
cerebral convexity meningioma
  • cerebral hemispheric convexity meningioma
gingival recession
  • gingival recession, localized
vestibulocochlear nerve disease
  • acoustic nerve disease
vestibular neuronitis
  • epidemic neurolabyrinthitis
- elite association - COSMIC cancer census association via MalaCards
Search VSIR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VSIR

genes like me logo Genes that share disorders with VSIR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VSIR Gene

Publications for VSIR Gene

  1. VISTA is an immune checkpoint molecule for human T cells. (PMID: 24691993) Lines JL … Noelle R (Cancer research 2014) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Characterization of programmed death-1 homologue-1 (PD-1H) expression and function in normal and HIV infected individuals. (PMID: 25279955) Bharaj P … Shankar P (PloS one 2014) 2 3 58
  4. GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. (PMID: 20666777) Sakr MA … Sato H (Cancer science 2010) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for VSIR Gene

Sources for VSIR Gene

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