Aliases for VSIG8 Gene

Aliases for VSIG8 Gene

  • V-Set And Immunoglobulin Domain Containing 8 2 3 5
  • V-Set And Immunoglobulin Domain-Containing Protein 8 3 4
  • C1orf204 4
  • VSIG8 5

External Ids for VSIG8 Gene

Previous GeneCards Identifiers for VSIG8 Gene

  • GC01M156638
  • GC01M158070
  • GC01M159824
  • GC01M131180
  • GC01M159855

Summaries for VSIG8 Gene

GeneCards Summary for VSIG8 Gene

VSIG8 (V-Set And Immunoglobulin Domain Containing 8) is a Protein Coding gene. Diseases associated with VSIG8 include Retinitis Pigmentosa 30 and Monilethrix. An important paralog of this gene is CXADR.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VSIG8 Gene

Genomics for VSIG8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for VSIG8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159853 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 600.4 +8.2 8161 2.9 PRDM10 ZNF629 ZNF692 ZIC2 POLR2A PATZ1 EZH2 ZNF600 ZNF341 ZFX ENSG00000272668 LOC107985216 SNHG28 VSIG8 ENSG00000256029 SLAMF8
GH01J159859 Enhancer 0.7 FANTOM5 Ensembl dbSUPER 600.7 +2.0 1956 2.2 FOXA1 ZIC2 GATA2 VSIG8 ENSG00000272668 OR10J5 KCNJ9 LOC107985216 SNHG28 ENSG00000256029 lnc-VSIG8-1 SLAMF8
GH01J159873 Promoter/Enhancer 0.7 EPDnew Ensembl dbSUPER 600.4 -10.9 -10944 1.2 ENSG00000256029 lnc-VSIG8-1 VSIG8 ENSG00000212161 ENSG00000272668 SLAMF8 FCRL6 HSALNG0007790 CFAP45
GH01J159862 Promoter 0.3 EPDnew 600.7 0.0 -20 0.1 VSIG8 ENSG00000272668 LOC107985216 ENSG00000256029 lnc-VSIG8-1
GH01J159908 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.8 -54.8 -54849 18.6 SP1 CREB1 HNRNPL PRDM10 ZNF629 REST RFX1 LEF1 IKZF1 ZNF692 TAGLN2 lnc-IGSF9-1 CFAP45 SNHG28 NCSTN SLAMF8 ENSG00000272668 RAD1P2 ENSG00000228606 VSIG8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VSIG8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VSIG8

Top Transcription factor binding sites by QIAGEN in the VSIG8 gene promoter:
  • AREB6
  • ARP-1
  • CBF(2)
  • CBF-B
  • CP1A
  • NF-kappaB1
  • Pax-5
  • RFX1
  • SRY
  • STAT3

Genomic Locations for VSIG8 Gene

Genomic Locations for VSIG8 Gene
chr1:159,854,316-159,862,657
(GRCh38/hg38)
Size:
8,342 bases
Orientation:
Minus strand
chr1:159,824,106-159,832,447
(GRCh37/hg19)
Size:
8,342 bases
Orientation:
Minus strand

Genomic View for VSIG8 Gene

Genes around VSIG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG8 Gene

Proteins for VSIG8 Gene

  • Protein details for VSIG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DPA2-VSIG8_HUMAN
    Recommended name:
    V-set and immunoglobulin domain-containing protein 8
    Protein Accession:
    P0DPA2
    Secondary Accessions:
    • Q5VU13
    • Q5VU14

    Protein attributes for VSIG8 Gene

    Size:
    414 amino acids
    Molecular mass:
    43891 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VSIG8 Gene

Post-translational modifications for VSIG8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VSIG8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for VSIG8

No data available for DME Specific Peptides for VSIG8 Gene

Domains & Families for VSIG8 Gene

Gene Families for VSIG8 Gene

Protein Domains for VSIG8 Gene

Suggested Antigen Peptide Sequences for VSIG8 Gene

GenScript: Design optimal peptide antigens:
  • V-set and immunoglobulin domain-containing protein 8 (VSIG8_HUMAN)
genes like me logo Genes that share domains with VSIG8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for VSIG8 Gene

Function for VSIG8 Gene

Phenotypes From GWAS Catalog for VSIG8 Gene

Gene Ontology (GO) - Molecular Function for VSIG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
genes like me logo Genes that share ontologies with VSIG8: view
genes like me logo Genes that share phenotypes with VSIG8: view

Animal Models for VSIG8 Gene

MGI Knock Outs for VSIG8:
  • Vsig8 Vsig8<tm1.1(KOMP)Mbp>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VSIG8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for VSIG8 Gene

Localization for VSIG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG8 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSIG8 gene
Compartment Confidence
plasma membrane 3
extracellular 2
peroxisome 0

Gene Ontology (GO) - Cellular Components for VSIG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIG8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VSIG8 Gene

Pathways & Interactions for VSIG8 Gene

PathCards logo

SuperPathways for VSIG8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VSIG8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VSIG8 Gene

Drugs & Compounds for VSIG8 Gene

No Compound Related Data Available

Transcripts for VSIG8 Gene

mRNA/cDNA for VSIG8 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VSIG8

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG8 Gene

No ASD Table

Relevant External Links for VSIG8 Gene

GeneLoc Exon Structure for
VSIG8

Expression for VSIG8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VSIG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x25.7) and Skin - Sun Exposed (Lower leg) (x6.7).

Protein differential expression in normal tissues from HIPED for VSIG8 Gene

This gene is overexpressed in Hair follicle (39.0), Bone marrow mesenchymal stem cell (15.7), and Plasma (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VSIG8 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VSIG8

SOURCE GeneReport for Unigene cluster for VSIG8 Gene:

Hs.647718
genes like me logo Genes that share expression patterns with VSIG8: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSIG8 Gene

Orthologs for VSIG8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia VSIG8 30 31
  • 97.25 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia VSIG8 30 31
  • 89.08 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Vsig8 30 17 31
  • 88.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Vsig8 30
  • 87.81 (n)
Cow
(Bos Taurus)
Mammalia VSIG8 30 31
  • 87.33 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia VSIG8 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia VSIG8 31
  • 65 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia VSIG8 31
  • 49 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100495227 30
  • 53.42 (n)
Zebrafish
(Danio rerio)
Actinopterygii vsig8b 31
  • 31 (a)
OneToMany
vsig8a 31
  • 28 (a)
OneToMany
Species where no ortholog for VSIG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for VSIG8 Gene

ENSEMBL:
Gene Tree for VSIG8 (if available)
TreeFam:
Gene Tree for VSIG8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VSIG8: view image

Paralogs for VSIG8 Gene

genes like me logo Genes that share paralogs with VSIG8: view

Variants for VSIG8 Gene

Additional dbSNP identifiers (rs#s) for VSIG8 Gene

Structural Variations from Database of Genomic Variants (DGV) for VSIG8 Gene

Variant ID Type Subtype PubMed ID
esv3578218 CNV loss 25503493
nsv1005195 CNV gain 25217958

Variation tolerance for VSIG8 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VSIG8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VSIG8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VSIG8 Gene

Disorders for VSIG8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for VSIG8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 30
  • rp30
monilethrix
  • mnlix
familial woolly hair syndrome
  • familial wooly hair syndrome
- elite association - COSMIC cancer census association via MalaCards
Search VSIG8 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with VSIG8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VSIG8 Gene

Publications for VSIG8 Gene

  1. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  2. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for VSIG8 Gene

  • Signalway Proteins for VSIG8

Sources for VSIG8 Gene