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Aliases for VSIG8 Gene

Aliases for VSIG8 Gene

  • V-Set And Immunoglobulin Domain Containing 8 2 3 5
  • C1orf204 4

External Ids for VSIG8 Gene

Previous GeneCards Identifiers for VSIG8 Gene

  • GC01M156638
  • GC01M158070
  • GC01M159824
  • GC01M131180

Summaries for VSIG8 Gene

GeneCards Summary for VSIG8 Gene

VSIG8 (V-Set And Immunoglobulin Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is CXADR.

Additional gene information for VSIG8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG8 Gene

Genomics for VSIG8 Gene

GeneHancer (GH) Regulatory Elements for VSIG8 Gene

Promoters and enhancers for VSIG8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I159862 Promoter 0.5 EPDnew 550.8 0.0 -20 0.1 VSIG8 ENSG00000272668 ENSG00000256029
GH01I159908 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.8 -54.8 -54826 18.5 CLOCK FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A TAGLN2 GC01M159919 GC01M159886 LOC100287049 NCSTN SLAMF8 RAD1P2 ENSG00000272668 SNHG28 VSIG8
GH01I159888 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -27.8 -27826 3 HDGF ATF1 SIN3A ZNF2 IRF4 GLIS2 ARID2 ZNF207 ZNF143 ATF7 ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01I159936 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.9 -78.8 -78800 10.5 PKNOX1 CLOCK SIN3A ZNF2 ZBTB7B YY1 ZNF143 KLF13 SP3 NFYC IGSF9 ATP1A4 KCNJ10 NHLH1 LINC01133 VSIG8 CFAP45 VANGL2 TAGLN2
GH01I159881 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.8 -19.5 -19478 1.7 PKNOX1 SMAD1 ATF7 FOS DEK ZNF491 ZNF518A ZNF592 MAFF SMARCA4 RPSAP18 ENSG00000272668 SNHG28 LOC100287049 SLAMF8 PIGM DCAF8 CADM3 CADM3-AS1 COPA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VSIG8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VSIG8 gene promoter:

Genomic Locations for VSIG8 Gene

Genomic Locations for VSIG8 Gene
chr1:159,854,316-159,862,657
(GRCh38/hg38)
Size:
8,342 bases
Orientation:
Minus strand
chr1:159,824,106-159,832,447
(GRCh37/hg19)

Genomic View for VSIG8 Gene

Genes around VSIG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG8 Gene

Proteins for VSIG8 Gene

  • Protein details for VSIG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DPA2-VSIG8_HUMAN
    Recommended name:
    V-set and immunoglobulin domain-containing protein 8
    Protein Accession:
    P0DPA2
    Secondary Accessions:
    • Q5VU13
    • Q5VU14

    Protein attributes for VSIG8 Gene

    Size:
    414 amino acids
    Molecular mass:
    43891 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VSIG8 Gene

Post-translational modifications for VSIG8 Gene

No Post-translational modifications

Other Protein References for VSIG8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSIG8 Gene

Domains & Families for VSIG8 Gene

Gene Families for VSIG8 Gene

Protein Domains for VSIG8 Gene

Suggested Antigen Peptide Sequences for VSIG8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VSIG8: view

No data available for UniProtKB/Swiss-Prot for VSIG8 Gene

Function for VSIG8 Gene

Phenotypes From GWAS Catalog for VSIG8 Gene

Gene Ontology (GO) - Molecular Function for VSIG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
genes like me logo Genes that share ontologies with VSIG8: view
genes like me logo Genes that share phenotypes with VSIG8: view

Animal Models for VSIG8 Gene

MGI Knock Outs for VSIG8:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for VSIG8 Gene

Localization for VSIG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSIG8 gene
Compartment Confidence
plasma membrane 3
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for VSIG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIG8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VSIG8 Gene

Pathways & Interactions for VSIG8 Gene

SuperPathways for VSIG8 Gene

No Data Available

Interacting Proteins for VSIG8 Gene

Gene Ontology (GO) - Biological Process for VSIG8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VSIG8 Gene

Drugs & Compounds for VSIG8 Gene

No Compound Related Data Available

Transcripts for VSIG8 Gene

mRNA/cDNA for VSIG8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VSIG8 Gene

V-set and immunoglobulin domain containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG8 Gene

No ASD Table

Relevant External Links for VSIG8 Gene

GeneLoc Exon Structure for
VSIG8
ECgene alternative splicing isoforms for
VSIG8

Expression for VSIG8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VSIG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x25.7) and Skin - Sun Exposed (Lower leg) (x6.7).

Protein differential expression in normal tissues from HIPED for VSIG8 Gene

This gene is overexpressed in Hair follicle (39.0), Bone marrow mesenchymal stem cell (15.7), and Plasma (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VSIG8 Gene



NURSA nuclear receptor signaling pathways regulating expression of VSIG8 Gene:

VSIG8

SOURCE GeneReport for Unigene cluster for VSIG8 Gene:

Hs.647718
genes like me logo Genes that share expression patterns with VSIG8: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSIG8 Gene

Orthologs for VSIG8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VSIG8 33 34
  • 97.25 (n)
dog
(Canis familiaris)
Mammalia VSIG8 33 34
  • 89.08 (n)
mouse
(Mus musculus)
Mammalia Vsig8 33 16 34
  • 88.14 (n)
rat
(Rattus norvegicus)
Mammalia Vsig8 33
  • 87.81 (n)
cow
(Bos Taurus)
Mammalia VSIG8 33 34
  • 87.33 (n)
oppossum
(Monodelphis domestica)
Mammalia VSIG8 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VSIG8 34
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VSIG8 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495227 33
  • 53.42 (n)
zebrafish
(Danio rerio)
Actinopterygii vsig8b 34
  • 31 (a)
OneToMany
vsig8a 34
  • 28 (a)
OneToMany
Species where no ortholog for VSIG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSIG8 Gene

ENSEMBL:
Gene Tree for VSIG8 (if available)
TreeFam:
Gene Tree for VSIG8 (if available)

Paralogs for VSIG8 Gene

Paralogs for VSIG8 Gene

genes like me logo Genes that share paralogs with VSIG8: view

Variants for VSIG8 Gene

Sequence variations from dbSNP and Humsavar for VSIG8 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000290851 -- 159,853,901(-) T/G downstream_transcript_variant
rs1001205670 -- 159,859,107(-) C/T intron_variant
rs1001886890 -- 159,856,331(-) G/A intron_variant
rs1002216971 -- 159,861,288(-) G/A intron_variant
rs1002229367 -- 159,854,979(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for VSIG8 Gene

Variant ID Type Subtype PubMed ID
nsv1005195 CNV gain 25217958
esv3578218 CNV loss 25503493

Variation tolerance for VSIG8 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VSIG8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VSIG8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSIG8 Gene

Disorders for VSIG8 Gene

Additional Disease Information for VSIG8

No disorders were found for VSIG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSIG8 Gene

Publications for VSIG8 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  3. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim TY … Major MB (Molecular and cellular biology 2015) 3 58
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for VSIG8 Gene

Sources for VSIG8 Gene

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