Aliases for VSIG2 Gene

Aliases for VSIG2 Gene

  • V-Set And Immunoglobulin Domain Containing 2 2 3 5
  • CTXL 2 3 4
  • CTH 2 3 4
  • V-Set And Immunoglobulin Domain-Containing Protein 2 3 4
  • Cortical Thymocyte-Like Protein 3 4
  • CT-Like Protein 3 4
  • Cortical Thymocyte Receptor (X. Laevis CTX) Like 3
  • 2210413P10Rik 3
  • VSIG2 5

External Ids for VSIG2 Gene

Previous GeneCards Identifiers for VSIG2 Gene

  • GC11M124122
  • GC11M124617
  • GC11M120559

Summaries for VSIG2 Gene

GeneCards Summary for VSIG2 Gene

VSIG2 (V-Set And Immunoglobulin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ESAM.

Additional gene information for VSIG2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VSIG2 Gene

Genomics for VSIG2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for VSIG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124753 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 608.4 +0.9 854 2 HNRNPL EZH2 PCBP1 ZNF792 GABPB1 ZGPAT SMAD4 BCL6 ZFP64 RARA VSIG2 LOC100507283 ENSG00000255045 NRGN
GH11J124752 Promoter/Enhancer 0.8 Ensembl dbSUPER 600.7 -0.7 -746 0.8 USF1 SPI1 ZBTB40 USF2 EZH2 VSIG2 MN309306 ESAM
GH11J124745 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 9.8 +4.2 4231 4.4 CTCF TEAD4 PRDM10 ZNF629 NFKBIZ FOXA1 LARP7 PRDM1 ZNF143 ZIC2 ENSG00000255045 SIAE VSIG2 NRGN LOC100507283 NONHSAG009936.2
GH11J124717 Enhancer 1 FANTOM5 ENCODE 12.2 +34.4 34373 1.2 PRDM10 ZNF629 ZNF692 ZIC2 PATZ1 EZH2 IKZF2 RCOR1 ZNF600 ZNF341 LOC107984405 ESAM NRGN ENSG00000255045 VSIG2 SIAE ENSG00000250073 SPA17 ROBO3 ROBO4
GH11J124836 Promoter/Enhancer 1.1 ENCODE CraniofacialAtlas 11 -84.6 -84646 1.6 CTCF PRDM1 ZNF143 ZSCAN4 REST RAD21 IKZF2 ZNF501 KLF9 KLF7 ROBO3 LOC100507283 MSANTD2 SIAE SPA17 ESAM ENSG00000250073 VSIG2 ENSG00000255045 NRGN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VSIG2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VSIG2

Top Transcription factor binding sites by QIAGEN in the VSIG2 gene promoter:
  • E47
  • GATA-1
  • Nkx2-5
  • Nkx5-1
  • POU3F1
  • POU3F2
  • Roaz
  • STAT3
  • STAT5A
  • Tal-1beta

Genomic Locations for VSIG2 Gene

Genomic Locations for VSIG2 Gene
4,782 bases
Minus strand
4,767 bases
Minus strand

Genomic View for VSIG2 Gene

Genes around VSIG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG2 Gene

Proteins for VSIG2 Gene

  • Protein details for VSIG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-set and immunoglobulin domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • O95791
    • Q9NX42

    Protein attributes for VSIG2 Gene

    327 amino acids
    Molecular mass:
    34348 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VSIG2 Gene


neXtProt entry for VSIG2 Gene

Post-translational modifications for VSIG2 Gene

  • Glycosylation at Asn138 and Asn206
  • Modification sites at PhosphoSitePlus

Other Protein References for VSIG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for VSIG2
  • Santa Cruz Biotechnology (SCBT) Antibodies for VSIG2

No data available for DME Specific Peptides for VSIG2 Gene

Domains & Families for VSIG2 Gene

Gene Families for VSIG2 Gene

Protein Domains for VSIG2 Gene

  • Immunoglobulin C-2 type

Suggested Antigen Peptide Sequences for VSIG2 Gene

GenScript: Design optimal peptide antigens:
  • Cortical thymocyte-like protein (VSIG2_HUMAN)
genes like me logo Genes that share domains with VSIG2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for VSIG2 Gene

Function for VSIG2 Gene

Phenotypes From GWAS Catalog for VSIG2 Gene

genes like me logo Genes that share phenotypes with VSIG2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VSIG2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VSIG2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VSIG2 Gene

Localization for VSIG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG2 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSIG2 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VSIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9862345
GO:0016020 membrane TAS 9862345
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIG2: view

Pathways & Interactions for VSIG2 Gene

PathCards logo

SuperPathways for VSIG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VSIG2 Gene


No data available for Pathways by source and SIGNOR curated interactions for VSIG2 Gene

Drugs & Compounds for VSIG2 Gene

No Compound Related Data Available

Transcripts for VSIG2 Gene

mRNA/cDNA for VSIG2 Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VSIG2

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8
SP1: - - - -
SP2: - - -
SP3: - -

Relevant External Links for VSIG2 Gene

GeneLoc Exon Structure for

Expression for VSIG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VSIG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG2 Gene

This gene is overexpressed in Stomach (x21.4), Colon - Transverse (x7.7), and Bladder (x6.2).

Protein differential expression in normal tissues from HIPED for VSIG2 Gene

This gene is overexpressed in Stomach (57.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VSIG2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VSIG2

SOURCE GeneReport for Unigene cluster for VSIG2 Gene:


mRNA Expression by UniProt/SwissProt for VSIG2 Gene:

Tissue specificity: Highly expressed in stomach, colon, prostate, trachea and thyroid glands and weakly in bladder and lung.

Evidence on tissue expression from TISSUES for VSIG2 Gene

  • Intestine(4.2)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with VSIG2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSIG2 Gene

Orthologs for VSIG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VSIG2 30 31
  • 99.49 (n)
(Canis familiaris)
Mammalia VSIG2 30 31
  • 86.86 (n)
(Bos Taurus)
Mammalia VSIG2 30 31
  • 85.89 (n)
(Rattus norvegicus)
Mammalia Vsig2 30
  • 84.57 (n)
(Mus musculus)
Mammalia Vsig2 30 17 31
  • 83.33 (n)
(Monodelphis domestica)
Mammalia VSIG2 31
  • 70 (a)
(Anolis carolinensis)
Reptilia VSIG2 31
  • 46 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia vsig2 30
  • 50.37 (n)
Species where no ortholog for VSIG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for VSIG2 Gene

Gene Tree for VSIG2 (if available)
Gene Tree for VSIG2 (if available)
Evolutionary constrained regions (ECRs) for VSIG2: view image

Paralogs for VSIG2 Gene

(2) SIMAP similar genes for VSIG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VSIG2: view

Variants for VSIG2 Gene

Additional dbSNP identifiers (rs#s) for VSIG2 Gene

Structural Variations from Database of Genomic Variants (DGV) for VSIG2 Gene

Variant ID Type Subtype PubMed ID
esv3627986 CNV gain 21293372
nsv556487 CNV loss 21841781
nsv952751 CNV deletion 24416366

Variation tolerance for VSIG2 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VSIG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VSIG2 Gene

Disorders for VSIG2 Gene

Additional Disease Information for VSIG2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for VSIG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSIG2 Gene

Publications for VSIG2 Gene

  1. CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates. (PMID: 9862345) Chrétien I … Du Pasquier L (European journal of immunology 1998) 2 3 4
  2. Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus. (PMID: 20659327) Kariuki SN … Niewold TB (Arthritis research & therapy 2010) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4

Products for VSIG2 Gene

Sources for VSIG2 Gene