Aliases for VSIG10L Gene

Aliases for VSIG10L Gene

  • V-Set And Immunoglobulin Domain Containing 10 Like 2 3 5
  • V-Set And Immunoglobulin Domain-Containing Protein 10-Like 3 4
  • VSIG10-Like Protein 3 4
  • VSIG10L 5

External Ids for VSIG10L Gene

Previous GeneCards Identifiers for VSIG10L Gene

  • GC19M056528
  • GC19M051834
  • GC19M048166

Summaries for VSIG10L Gene

GeneCards Summary for VSIG10L Gene

VSIG10L (V-Set And Immunoglobulin Domain Containing 10 Like) is a Protein Coding gene. Diseases associated with VSIG10L include Palmoplantar Keratoderma, Punctate Type Ia and Punctate Palmoplantar Keratoderma. An important paralog of this gene is HMCN2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VSIG10L Gene

Genomics for VSIG10L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for VSIG10L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051338 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 260.1 +2.3 2338 3.2 TBP ZBTB10 SP1 MXD4 NR2C1 MNT DEK IKZF1 SMAD5 MBD2 VSIG10L ENSG00000267905 ZNF841 ZNF577 POLD1 ZNF616 ZNF175 ZNF480 ZNF766 ZNF350
GH19J051343 Enhancer 0.7 ENCODE 250.7 -1.1 -1095 0 ZNF511 TEAD3 RBM22 KDM1A PTBP1 HDAC2 ZNF143 HNRNPH1 ZFP36 ZMYM3 ENSG00000267984 VSIG10L ZNF616 POLD1 ZNF841 ZNF480 ZNF836 ZNF766 ZNF577 ENSG00000268316
GH19J051342 Enhancer 0.5 ENCODE 259.8 -0.6 -563 0.2 ZBTB10 IKZF1 RBM22 PTBP1 HNRNPH1 KDM1A BCOR RBFOX2 ZMYM3 VSIG10L ZNF616 POLD1 ZNF841 ZNF480 ZNF836 ZNF766 ZNF577 ENSG00000268316 SIGLEC17P
GH19J051341 Enhancer 0.4 ENCODE 250.7 +0.2 177 0.2 REST MIER2 RXRB RBFOX2 ENSG00000267905 VSIG10L IGLON5
GH19J051360 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.4 -26.4 -26422 15.8 ZSCAN16 CHD2 TBP ZBTB10 SP1 MXD4 CEBPA NR2C1 FOXA1 MNT ETFB CLDND2 ENSG00000269403 HSALNG0127209 NKG7 NONHSAG026361.2 ZNF841 ZNF175 ZNF616 ZNF577
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VSIG10L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VSIG10L

Genomic Locations for VSIG10L Gene

Latest Assembly
10,604 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
10,599 bases
Minus strand

(GRCh37/hg19 by Ensembl)
10,589 bases
Minus strand

Genomic View for VSIG10L Gene

Genes around VSIG10L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG10L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG10L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG10L Gene

Proteins for VSIG10L Gene

  • Protein details for VSIG10L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-set and immunoglobulin domain-containing protein 10-like
    Protein Accession:

    Protein attributes for VSIG10L Gene

    867 amino acids
    Molecular mass:
    91625 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VSIG10L Gene


neXtProt entry for VSIG10L Gene

Post-translational modifications for VSIG10L Gene

  • Glycosylation at Asn32, Asn88, Asn96, Asn144, Asn423, Asn487, Asn641, and Asn650
  • Modification sites at PhosphoSitePlus

Other Protein References for VSIG10L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSIG10L Gene

Domains & Families for VSIG10L Gene

Gene Families for VSIG10L Gene

Protein Domains for VSIG10L Gene

Suggested Antigen Peptide Sequences for VSIG10L Gene

GenScript: Design optimal peptide antigens:
  • V-set and immunoglobulin domain-containing protein 10-like (VS10L_HUMAN)
genes like me logo Genes that share domains with VSIG10L: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for VSIG10L Gene

Function for VSIG10L Gene

Phenotypes From GWAS Catalog for VSIG10L Gene

Phenotypes for VSIG10L Gene

genes like me logo Genes that share phenotypes with VSIG10L: view

Animal Models for research

  • Taconic Biosciences Mouse Models for VSIG10L

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VSIG10L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VSIG10L Gene

Localization for VSIG10L Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG10L Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSIG10L gene
Compartment Confidence
nucleus 4
plasma membrane 2
extracellular 1
cytosol 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VSIG10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIG10L: view

Pathways & Interactions for VSIG10L Gene

PathCards logo

SuperPathways for VSIG10L Gene

No Data Available

Interacting Proteins for VSIG10L Gene

Selected Interacting proteins: Q86VR7-VS10L_HUMAN for VSIG10L Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for VSIG10L Gene


No data available for Pathways by source and SIGNOR curated interactions for VSIG10L Gene

Drugs & Compounds for VSIG10L Gene

No Compound Related Data Available

Transcripts for VSIG10L Gene

mRNA/cDNA for VSIG10L Gene

5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for VSIG10L

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG10L Gene

No ASD Table

Relevant External Links for VSIG10L Gene

GeneLoc Exon Structure for

Expression for VSIG10L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VSIG10L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG10L Gene

This gene is overexpressed in Esophagus - Mucosa (x20.7), Vagina (x6.0), and Cervix - Ectocervix (x5.4).

Protein differential expression in normal tissues from HIPED for VSIG10L Gene

This gene is overexpressed in Saliva (39.3) and Esophagus (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VSIG10L Gene

Protein tissue co-expression partners for VSIG10L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VSIG10L

SOURCE GeneReport for Unigene cluster for VSIG10L Gene:


mRNA Expression by UniProt/SwissProt for VSIG10L Gene:

Tissue specificity: Expressed in the esophagus, particularly in the suprabasilar layers of the epithelium. Expression is largely reduced in esophageal metaplasia, dysplasia, and adenocarcinoma lesions.

Evidence on tissue expression from TISSUES for VSIG10L Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with VSIG10L: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VSIG10L Gene

Orthologs for VSIG10L Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG10L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VSIG10L 30 31
  • 98.15 (n)
(Canis familiaris)
Mammalia VSIG10L 30 31
  • 82.76 (n)
(Bos Taurus)
Mammalia VSIG10L 30 31
  • 80.53 (n)
(Mus musculus)
Mammalia Vsig10l 30 17 31
  • 77.1 (n)
(Rattus norvegicus)
Mammalia Vsig10l 30
  • 76.33 (n)
(Ornithorhynchus anatinus)
Mammalia VSIG10L 31
  • 56 (a)
(Monodelphis domestica)
Mammalia VSIG10L 31
  • 55 (a)
(Anolis carolinensis)
Reptilia VSIG10L 31
  • 37 (a)
(Danio rerio)
Actinopterygii LOC100333975 30
  • 41.81 (n)
VSIG10L 31
  • 24 (a)
Species where no ortholog for VSIG10L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for VSIG10L Gene

Gene Tree for VSIG10L (if available)
Gene Tree for VSIG10L (if available)
Evolutionary constrained regions (ECRs) for VSIG10L: view image

Paralogs for VSIG10L Gene

Variants for VSIG10L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VSIG10L Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs111872099 Benign: not provided 51,334,311(-) G/A
rs141732375 Benign: not provided 51,341,816(-) A/T
NM_001163922.2(VSIG10L):c.232T>A (p.Ser78Thr)
rs148937058 Benign: not provided 51,340,423(-) C/T
rs1599831835 Likely Benign: not provided 51,333,890(-) G/A
NM_001163922.2(VSIG10L):c.2475C>T (p.Pro825=)
rs57710066 Benign: not provided. - 51,338,058(-) C/Tp.Arg627His
NM_001163922.2(VSIG10L):c.1880G>A (p.Arg627His)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for VSIG10L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for VSIG10L Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for VSIG10L Gene

Gene Damage Index Score: 3.84; 58.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VSIG10L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSIG10L Gene

Disorders for VSIG10L Gene

MalaCards: The human disease database

(2) MalaCards diseases for VSIG10L Gene - From: COP

Disorder Aliases PubMed IDs
palmoplantar keratoderma, punctate type ia
  • ppkp1a
punctate palmoplantar keratoderma
  • punctate keratosis palmoplantaris
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for VSIG10L

genes like me logo Genes that share disorders with VSIG10L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VSIG10L Gene

Publications for VSIG10L Gene

  1. Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia. (PMID: 27467440) Fecteau RE … Chak A (JAMA oncology 2016) 2 3 4
  2. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
  3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. (PMID: 25468996) Guo Z … Zaidel-Bar R (Science signaling 2014) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for VSIG10L Gene

Sources for VSIG10L Gene