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Aliases for VSIG1 Gene

Aliases for VSIG1 Gene

  • V-Set And Immunoglobulin Domain Containing 1 2 3 5
  • Cell Surface A33 Antigen 3 4
  • Glycoprotein A34 3 4
  • GPA34 3 4
  • V-Set And Immunoglobulin Domain-Containing Protein 1 3
  • 1700062D20Rik 3
  • DJ889N15.1 3

External Ids for VSIG1 Gene

Previous GeneCards Identifiers for VSIG1 Gene

  • GC0XP107094
  • GC0XP107174
  • GC0XP107288
  • GC0XP096911

Summaries for VSIG1 Gene

Entrez Gene Summary for VSIG1 Gene

  • This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for VSIG1 Gene

VSIG1 (V-Set And Immunoglobulin Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is IGSF11.

Additional gene information for VSIG1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG1 Gene

Genomics for VSIG1 Gene

GeneHancer (GH) Regulatory Elements for VSIG1 Gene

Promoters and enhancers for VSIG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI108044 Promoter/Enhancer 0.9 EPDnew ENCODE 550.3 +26.4 26409 0.9 MAFG MAFK VSIG1 GC0XM108072
GH0XI108017 Enhancer 0.3 ENCODE 550.8 -0.3 -303 1.4 RUNX3 VSIG1 TEX13B PIR62324
GH0XI108072 Enhancer 0.8 Ensembl ENCODE 12.7 +53.4 53350 0.3 CTCF PKNOX1 ZNF654 TRIM22 ZNF384 REST RAD21 YY1 ZNF148 ZNF335 GC0XM108072 VSIG1 ATG4A
GH0XI108070 Enhancer 0.6 ENCODE 12.9 +52.4 52410 1.4 ZNF335 CTCF ZNF654 TRIM22 ZNF384 FOS RAD21 YY1 GC0XM108072 VSIG1 TEX13B ATG4A
GH0XI107978 Enhancer 0.2 ENCODE 15.2 -40.6 -40640 0.2 VSIG1 TEX13B NLRP3P1 ENSG00000225728
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VSIG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VSIG1 gene promoter:

Genomic Locations for VSIG1 Gene

Genomic Locations for VSIG1 Gene
60,279 bases
Plus strand

Genomic View for VSIG1 Gene

Genes around VSIG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG1 Gene

Proteins for VSIG1 Gene

  • Protein details for VSIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-set and immunoglobulin domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • C9J4P2
    • Q6MZS4

    Protein attributes for VSIG1 Gene

    387 amino acids
    Molecular mass:
    41811 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAE45954.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VSIG1 Gene


neXtProt entry for VSIG1 Gene

Post-translational modifications for VSIG1 Gene

  • Highly N-glycosylated. Appears not to contain significant amounts of O-linked carbohydrates or sialic acid in its sugar moieties.
  • Glycosylation at isoforms=232, isoforms=238, posLast=133133, isoforms=2200, and isoforms=2219

Other Protein References for VSIG1 Gene

No data available for DME Specific Peptides for VSIG1 Gene

Domains & Families for VSIG1 Gene

Gene Families for VSIG1 Gene

Suggested Antigen Peptide Sequences for VSIG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VSIG1: view

No data available for UniProtKB/Swiss-Prot for VSIG1 Gene

Function for VSIG1 Gene

genes like me logo Genes that share phenotypes with VSIG1: view

Animal Models for VSIG1 Gene

MGI Knock Outs for VSIG1:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VSIG1 Gene

Localization for VSIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSIG1 gene
Compartment Confidence
plasma membrane 4
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VSIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIG1: view

Pathways & Interactions for VSIG1 Gene

SuperPathways for VSIG1 Gene

No Data Available

Interacting Proteins for VSIG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000402219 Q86XK7-VSIG1_HUMAN for VSIG1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for VSIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003382 epithelial cell morphogenesis IEA --
GO:0030277 maintenance of gastrointestinal epithelium IEA --
genes like me logo Genes that share ontologies with VSIG1: view

No data available for Pathways by source and SIGNOR curated interactions for VSIG1 Gene

Drugs & Compounds for VSIG1 Gene

No Compound Related Data Available

Transcripts for VSIG1 Gene

Unigene Clusters for VSIG1 Gene

V-set and immunoglobulin domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG1 Gene

No ASD Table

Relevant External Links for VSIG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VSIG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VSIG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG1 Gene

This gene is overexpressed in Stomach (x34.7) and Testis (x11.6).

Protein differential expression in normal tissues from HIPED for VSIG1 Gene

This gene is overexpressed in Stomach (36.1), Testis (21.6), and Ovary (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VSIG1 Gene

Protein tissue co-expression partners for VSIG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of VSIG1 Gene:


SOURCE GeneReport for Unigene cluster for VSIG1 Gene:


mRNA Expression by UniProt/SwissProt for VSIG1 Gene:

Tissue specificity: Detected only in stomach mucosa and testis, and to a much lesser level in pancreas (at protein level). Detected in gastric cancers (31%), esophageal carcinomas (50%) and ovarian cancers (23%).

Evidence on tissue expression from TISSUES for VSIG1 Gene

  • Stomach(4.7)
genes like me logo Genes that share expression patterns with VSIG1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VSIG1 Gene

Orthologs for VSIG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VSIG1 33 34
  • 99.66 (n)
(Canis familiaris)
Mammalia VSIG1 33 34
  • 80.93 (n)
(Bos Taurus)
Mammalia VSIG1 33 34
  • 79.5 (n)
(Rattus norvegicus)
Mammalia Vsig1 33
  • 78.47 (n)
(Mus musculus)
Mammalia Vsig1 33 16 34
  • 75.76 (n)
(Monodelphis domestica)
Mammalia VSIG1 34
  • 57 (a)
(Gallus gallus)
Aves VSIG1 33 34
  • 57.48 (n)
(Anolis carolinensis)
Reptilia VSIG1 34
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vsig1 33
  • 52.65 (n)
(Danio rerio)
Actinopterygii zgc:165604 34
  • 27 (a)
Species where no ortholog for VSIG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSIG1 Gene

Gene Tree for VSIG1 (if available)
Gene Tree for VSIG1 (if available)

Paralogs for VSIG1 Gene

Paralogs for VSIG1 Gene

(2) SIMAP similar genes for VSIG1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VSIG1: view

Variants for VSIG1 Gene

Sequence variations from dbSNP and Humsavar for VSIG1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000006215 -- 108,063,458(+) T/C intron_variant
rs1000202294 -- 108,046,025(+) A/G intron_variant
rs1000251717 -- 108,028,199(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000260646 -- 108,036,822(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000269279 -- 108,034,321(+) C/G genic_upstream_transcript_variant, intron_variant

Variation tolerance for VSIG1 Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VSIG1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VSIG1 Gene

Disorders for VSIG1 Gene

Additional Disease Information for VSIG1

No disorders were found for VSIG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSIG1 Gene

Publications for VSIG1 Gene

  1. Glycoprotein A34, a novel target for antibody-based cancer immunotherapy. (PMID: 16405301) Scanlan MJ … Jungbluth AA (Cancer immunity 2006) 3 4 22 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Characterization of V-set and immunoglobulin domain containing 1 exerting a tumor suppressor function in gastric, lung, and esophageal cancer cells. (PMID: 28603843) Inoue Y … Sugimura H (Cancer science 2017) 3 58
  5. Decreased expression of V-set and immunoglobulin domain containing 1 (VSIG1) is associated with poor prognosis in primary gastric cancer. (PMID: 22095633) Chen Y … Li Q (Journal of surgical oncology 2012) 3 58

Products for VSIG1 Gene

Sources for VSIG1 Gene

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