Aliases for VRK3 Gene
External Ids for VRK3 Gene
Previous GeneCards Identifiers for VRK3 Gene
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for VRK3 Gene
VRK3 (VRK Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with VRK3 include Vaccinia. Among its related pathways are Activated TLR4 signalling and Nuclear Events (kinase and transcription factor activation). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is VRK2.
UniProtKB/Swiss-Prot Summary for VRK3 Gene
Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.