This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular locali... See more...

Aliases for VRK2 Gene

Aliases for VRK2 Gene

  • VRK Serine/Threonine Kinase 2 2 3 5
  • Serine/Threonine-Protein Kinase VRK2 3 4
  • Vaccinia Related Kinase 2 2 3
  • EC 2.7.11.1 4 52
  • Vaccinia Virus B1R-Related Kinase 2 3
  • Vaccinia-Related Kinase 2 4

External Ids for VRK2 Gene

Previous GeneCards Identifiers for VRK2 Gene

  • GC02P058402
  • GC02P058092
  • GC02P058248
  • GC02P058185

Summaries for VRK2 Gene

Entrez Gene Summary for VRK2 Gene

  • This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

GeneCards Summary for VRK2 Gene

VRK2 (VRK Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases associated with VRK2 include Vaccinia and Fanconi Anemia, Complementation Group L. Among its related pathways are Nuclear Envelope Reassembly and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is VRK1.

UniProtKB/Swiss-Prot Summary for VRK2 Gene

  • Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
  • Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.

Gene Wiki entry for VRK2 Gene

Additional gene information for VRK2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VRK2 Gene

Genomics for VRK2 Gene

GeneHancer (GH) Regulatory Elements for VRK2 Gene

Promoters and enhancers for VRK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J058044 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 515.6 +139.1 139104 4.5 HNRNPK ZNF217 SIN3A NRF1 TCF12 MYC POLR2G SP1 GTF2E2 PHF8 VRK2 ENSG00000287875 LOC105374726 FANCL
GH02J057906 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 514.6 +0.9 871 5 CTCF TEAD4 EP300 REST RELA ZBTB25 RAD21 TRIM22 POLR2A TEAD1 VRK2 lnc-CCDC85A-6 piR-50437-378
GH02J058107 Enhancer 1 FANTOM5 ENCODE 23.2 +200.9 200925 2.8 TCF12 FOS POLR2A EP300 BRCA1 SIX5 FOSL2 CEBPB CHD2 JUN VRK2 FANCL piR-37432-055 lnc-FANCL-5
GH02J058112 Enhancer 0.8 FANTOM5 ENCODE 23.5 +205.6 205550 2 FOS SPI1 POLR3A POLR2A GTF3C2 JUND STAT3 VRK2 piR-37432-055 lnc-FANCL-5
GH02J057890 Enhancer 1.6 UCNEbase FANTOM5 Ensembl ENCODE 11.4 -14.9 -14928 5 ZBTB40 EP300 RELA MEF2C TEAD1 TBX3 BCL11A TCF12 FOXA2 CBFB VRK2 LOC105377632
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VRK2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for VRK2

Top Transcription factor binding sites by QIAGEN in the VRK2 gene promoter:
  • E4BP4
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx3-1
  • p53

Genomic Locations for VRK2 Gene

Genomic Locations for VRK2 Gene
chr2:57,907,629-58,159,920
(GRCh38/hg38)
Size:
252,292 bases
Orientation:
Plus strand
chr2:58,134,786-58,387,055
(GRCh37/hg19)
Size:
252,270 bases
Orientation:
Plus strand

Genomic View for VRK2 Gene

Genes around VRK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VRK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VRK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VRK2 Gene

Proteins for VRK2 Gene

  • Protein details for VRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y07-VRK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase VRK2
    Protein Accession:
    Q86Y07
    Secondary Accessions:
    • B4DKL0
    • D6W5D4
    • D6W5D6
    • Q49AK9
    • Q53EU9
    • Q53S39
    • Q53S77
    • Q53TU1
    • Q86Y08
    • Q86Y09
    • Q86Y10
    • Q86Y11
    • Q86Y12
    • Q8IXI5
    • Q99987

    Protein attributes for VRK2 Gene

    Size:
    508 amino acids
    Molecular mass:
    58141 Da
    Quaternary structure:
    • Isoform 1 interacts with MAP3K7, MAP2K7, MAP2K1 and KSR1. Isoform 1 and isoform 2 interact with RAN and MAPK8IP1.
    • (Microbial infection) Isoform 1 interacts with Epstein-Barr virus BHRF1; this interaction is involved in protecting cells from apoptosis.
    SequenceCaution:
    • Sequence=CAD54446.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VRK2 Gene

    Alternative splice isoforms for VRK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VRK2 Gene

Selected DME Specific Peptides for VRK2 Gene

Q86Y07:
  • EYVHGDIKA
  • HENEYVHG

Post-translational modifications for VRK2 Gene

Domains & Families for VRK2 Gene

Gene Families for VRK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for VRK2 Gene

Suggested Antigen Peptide Sequences for VRK2 Gene

GenScript: Design optimal peptide antigens:
  • VRK2 protein (Q05CR6_HUMAN)
  • Vaccinia-related kinase 2 (VRK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86Y07

UniProtKB/Swiss-Prot:

VRK2_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
genes like me logo Genes that share domains with VRK2: view

Function for VRK2 Gene

Molecular function for VRK2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
UniProtKB/Swiss-Prot Function:
Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
RAN inhibits its autophosphorylation and its ability to phosphorylate histone H3.
GENATLAS Biochemistry:
vaccinia-related kinase 2,widely expressed

Enzyme Numbers (IUBMB) for VRK2 Gene

Phenotypes From GWAS Catalog for VRK2 Gene

Gene Ontology (GO) - Molecular Function for VRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,TAS 14645249
GO:0005515 protein binding IPI 16963744
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with VRK2: view
genes like me logo Genes that share phenotypes with VRK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VRK2

CRISPR Products

Clone Products

  • Addgene plasmids for VRK2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VRK2 Gene

Localization for VRK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VRK2 Gene

[Isoform 1]: Cytoplasm. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein. Nucleus envelope.
[Isoform 2]: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VRK2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endosome 1
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA 16704422
GO:0005635 nuclear envelope ISS --
GO:0005737 cytoplasm IDA,IBA 16704422
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA 22572157
genes like me logo Genes that share ontologies with VRK2: view

Pathways & Interactions for VRK2 Gene

genes like me logo Genes that share pathways with VRK2: view

SIGNOR curated interactions for VRK2 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for VRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 9344656
GO:0016032 viral process IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0034599 cellular response to oxidative stress IMP 17709393
genes like me logo Genes that share ontologies with VRK2: view

Drugs & Compounds for VRK2 Gene

(1) Drugs for VRK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for VRK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with VRK2: view

Transcripts for VRK2 Gene

mRNA/cDNA for VRK2 Gene

9 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for VRK2

Alternative Splicing Database (ASD) splice patterns (SP) for VRK2 Gene

No ASD Table

Relevant External Links for VRK2 Gene

GeneLoc Exon Structure for
VRK2

Expression for VRK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VRK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VRK2 Gene

This gene is overexpressed in Breast (45.7) and Lung (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VRK2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for VRK2

SOURCE GeneReport for Unigene cluster for VRK2 Gene:

Hs.744058

mRNA Expression by UniProt/SwissProt for VRK2 Gene:

Q86Y07-VRK2_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.

Evidence on tissue expression from TISSUES for VRK2 Gene

  • Intestine(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with VRK2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VRK2 Gene

Orthologs for VRK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for VRK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VRK2 31 30
  • 99.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia VRK2 31 30
  • 88.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia VRK2 31 30
  • 85.28 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vrk2 30
  • 83.41 (n)
mouse
(Mus musculus)
Mammalia Vrk2 17 31 30
  • 78.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VRK2 31
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VRK2 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves VRK2 31 30
  • 65.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VRK2 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vrk2 30
  • 56.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia vrk2-prov 30
zebrafish
(Danio rerio)
Actinopterygii vrk2 31 30
  • 63.48 (n)
OneToOne
zgc56483 30
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD09009 32
  • 41 (a)
ball 31
  • 28 (a)
ManyToMany
CG8878 31
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F28B12.3 32
  • 30 (a)
vrk-1 31
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6830 31
  • 44 (a)
OneToMany
Species where no ortholog for VRK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VRK2 Gene

ENSEMBL:
Gene Tree for VRK2 (if available)
TreeFam:
Gene Tree for VRK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VRK2: view image

Paralogs for VRK2 Gene

(3) SIMAP similar genes for VRK2 Gene using alignment to 4 proteins:

  • VRK2_HUMAN
  • E7ERS5_HUMAN
  • E9PBU1_HUMAN
  • Q05CR6_HUMAN
genes like me logo Genes that share paralogs with VRK2: view

Variants for VRK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for VRK2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
641689 Uncertain Significance: Fanconi anemia 58,160,112(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
656401 Uncertain Significance: Fanconi anemia 58,162,906(+) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
660117 Uncertain Significance: Fanconi anemia 58,160,148(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
698894 Benign: not provided 58,163,470(+) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
726571 Likely Benign: not provided 58,163,082(+) T/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for VRK2 Gene

Structural Variations from Database of Genomic Variants (DGV) for VRK2 Gene

Variant ID Type Subtype PubMed ID
esv1774125 CNV insertion 17803354
esv21948 CNV loss 19812545
esv2230992 CNV deletion 18987734
esv2596143 CNV deletion 19546169
esv2660402 CNV deletion 23128226
esv2674793 CNV deletion 23128226
esv3583839 CNV loss 25503493
esv3590950 CNV loss 21293372
esv3590951 CNV loss 21293372
esv3590953 CNV loss 21293372
esv3590954 CNV gain 21293372
esv3892537 CNV loss 25118596
nsv1109253 CNV deletion 24896259
nsv1125689 CNV tandem duplication 24896259
nsv1133273 CNV tandem duplication 24896259
nsv1134865 CNV deletion 24896259
nsv457985 CNV gain 19166990
nsv458041 CNV loss 19166990
nsv475869 CNV novel sequence insertion 20440878
nsv525988 CNV gain 19592680
nsv527551 CNV loss 19592680
nsv582086 CNV gain 21841781
nsv582096 CNV loss 21841781
nsv582097 CNV loss 21841781
nsv834159 CNV gain 17160897
nsv954236 CNV insertion 24416366
nsv999591 CNV loss 25217958

Variation tolerance for VRK2 Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.86; 91.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VRK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VRK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VRK2 Gene

Disorders for VRK2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for VRK2 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search VRK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VRK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with VRK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VRK2 Gene

Publications for VRK2 Gene

  1. Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. (PMID: 18286207) Blanco S … Lazo PA (PloS one 2008) 3 4 23 54
  2. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PMID: 18617507) Sanz-García M … Lazo PA (Molecular & cellular proteomics : MCP 2008) 3 4 23 54
  3. Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. (PMID: 17709393) Blanco S … Lazo PA (Molecular and cellular biology 2007) 3 4 23 54
  4. The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines. (PMID: 16704422) Blanco S … Lazo PA (The FEBS journal 2006) 3 4 23 54
  5. Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival. (PMID: 16963744) Li LY … Chen JY (The Journal of general virology 2006) 3 4 23 54

Products for VRK2 Gene

Sources for VRK2 Gene