Aliases for VPS37C Gene
External Ids for VPS37C Gene
Previous GeneCards Identifiers for VPS37C Gene
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
GeneCards Summary for VPS37C Gene
VPS37C (VPS37C Subunit Of ESCRT-I) is a Protein Coding gene. Diseases associated with VPS37C include Nipah Virus Encephalitis and Phencyclidine Abuse. Among its related pathways are Vesicle-mediated transport and Budding and maturation of HIV virion. Gene Ontology (GO) annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is VPS37B.
UniProtKB/Swiss-Prot Summary for VPS37C Gene
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.