Aliases for VPS37C Gene
External Ids for VPS37C Gene
Previous GeneCards Identifiers for VPS37C Gene
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
GeneCards Summary for VPS37C Gene
VPS37C (VPS37C Subunit Of ESCRT-I) is a Protein Coding gene. Diseases associated with VPS37C include Nipah Virus Encephalitis and Phencyclidine Abuse. Among its related pathways are Budding and maturation of HIV virion and Endocytosis. Gene Ontology (GO) annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is VPS37B.
UniProtKB/Swiss-Prot Summary for VPS37C Gene
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.