Aliases for VPS37B Gene

Aliases for VPS37B Gene

  • VPS37B Subunit Of ESCRT-I 2 3 5
  • Vacuolar Protein Sorting-Associated Protein 37B 3 4
  • ESCRT-I Complex Subunit VPS37B 3 4
  • HVps37B 3 4
  • Vacuolar Protein Sorting 37 Homolog B (S. Cerevisiae) 2
  • Vacuolar Protein Sorting 37 Homolog B 3
  • Vacuolar Protein Sorting 37B (Yeast) 2
  • Vacuolar Protein Sorting 37B 3
  • VPS37B, ESCRT-I Subunit 3

External Ids for VPS37B Gene

Previous GeneCards Identifiers for VPS37B Gene

  • GC12M121875
  • GC12M123349
  • GC12M120309

Summaries for VPS37B Gene

GeneCards Summary for VPS37B Gene

VPS37B (VPS37B Subunit Of ESCRT-I) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is VPS37C.

UniProtKB/Swiss-Prot Summary for VPS37B Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Additional gene information for VPS37B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for VPS37B Gene

Genomics for VPS37B Gene

GeneHancer (GH) Regulatory Elements for VPS37B Gene

Promoters and enhancers for VPS37B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J122885 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 769.6 +4.6 4595 11.6 E2F8 SP1 ZBTB40 ZBTB6 FOXA1 SMARCE1 POLR2A USF2 ATF1 CREB1 VPS37B RSRC2 EIF2B1 ZCCHC8 ATP6V0A2 DDX55 KNTC1 GTF2H3 C12orf65 TCTN2
GH12J122866 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 31.9 +28.5 28451 2.7 CTCF NR2F1 RAD21 SP1 CEBPG MLLT1 SP5 CEBPA RXRA REST piR-46783 piR-48687 VPS37B HIP1R CCDC62 PITPNM2 B3GNT4 ENSG00000256152
GH12J122834 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 18.1 +57.5 57521 9.4 CTCF SMARCE1 POLR2A ZNF362 MYC L3MBTL2 MAX MNT ZNF148 ZFX HIP1R VPS37B TCTN2 C12orf65 GTF2H3 DDX55 ABCB9 B3GNT4 piR-39703
GH12J122870 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 24.4 +24.0 23972 4.3 TCF7L2 MYC ETV6 MAX POU5F1 MNT SP1 MAFK CREM IKZF1 VPS37B HIP1R CCDC62 B3GNT4 piR-46783 lnc-ABCB9-2 ENSG00000280138
GH12J122879 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.3 +13.7 13662 6.1 ZNF362 CTCF SP7 PRDM1 IKZF1 ZIC2 REST PRDM10 ZBTB33 ZSCAN4 VPS37B OGFOD2 ABCB9 B3GNT4 ENSG00000280138 lnc-ABCB9-2 piR-46783
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around VPS37B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VPS37B gene promoter:
  • AML1a
  • deltaCREB
  • E47
  • POU2F1
  • POU2F1a
  • RP58
  • Tal-1

Genomic Locations for VPS37B Gene

Genomic Locations for VPS37B Gene
chr12:122,865,328-122,896,220
(GRCh38/hg38)
Size:
30,893 bases
Orientation:
Minus strand
chr12:123,349,875-123,380,991
(GRCh37/hg19)
Size:
31,117 bases
Orientation:
Minus strand

Genomic View for VPS37B Gene

Genes around VPS37B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPS37B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPS37B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS37B Gene

Proteins for VPS37B Gene

  • Protein details for VPS37B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9H4-VP37B_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 37B
    Protein Accession:
    Q9H9H4

    Protein attributes for VPS37B Gene

    Size:
    285 amino acids
    Molecular mass:
    31307 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with CEP55. Interacts with IST1.

neXtProt entry for VPS37B Gene

Post-translational modifications for VPS37B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VPS37B Gene

Domains & Families for VPS37B Gene

Gene Families for VPS37B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for VPS37B Gene

Suggested Antigen Peptide Sequences for VPS37B Gene

GenScript: Design optimal peptide antigens:
  • ESCRT-I complex subunit VPS37B (VP37B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H9H4

UniProtKB/Swiss-Prot:

VP37B_HUMAN :
  • Belongs to the VPS37 family.
Family:
  • Belongs to the VPS37 family.
genes like me logo Genes that share domains with VPS37B: view

Function for VPS37B Gene

Molecular function for VPS37B Gene

UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Phenotypes From GWAS Catalog for VPS37B Gene

Gene Ontology (GO) - Molecular Function for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15218037
GO:0048306 calcium-dependent protein binding IPI 23924735
genes like me logo Genes that share ontologies with VPS37B: view
genes like me logo Genes that share phenotypes with VPS37B: view

Animal Model Products

CRISPR Products

miRNA for VPS37B Gene

miRTarBase miRNAs that target VPS37B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPS37B Gene

Localization for VPS37B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS37B Gene

Late endosome membrane; Peripheral membrane protein. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VPS37B gene
Compartment Confidence
plasma membrane 5
endosome 5
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex TAS 20588296
GO:0005737 cytoplasm IDA 15218037
GO:0005768 endosome IEA,IDA 17940959
GO:0005886 plasma membrane IDA 17940959
GO:0010008 endosome membrane TAS,IDA --
genes like me logo Genes that share ontologies with VPS37B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VPS37B Gene

Pathways & Interactions for VPS37B Gene

genes like me logo Genes that share pathways with VPS37B: view

Pathways by source for VPS37B Gene

Gene Ontology (GO) - Biological Process for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA 21873635
GO:0006623 protein targeting to vacuole IBA 21873635
GO:0015031 protein transport IEA --
GO:0016197 endosomal transport TAS --
GO:0016236 macroautophagy TAS 20588296
genes like me logo Genes that share ontologies with VPS37B: view

No data available for SIGNOR curated interactions for VPS37B Gene

Drugs & Compounds for VPS37B Gene

No Compound Related Data Available

Transcripts for VPS37B Gene

mRNA/cDNA for VPS37B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(277) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS37B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for VPS37B Gene

GeneLoc Exon Structure for
VPS37B
ECgene alternative splicing isoforms for
VPS37B

Expression for VPS37B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VPS37B Gene

mRNA differential expression in normal tissues according to GTEx for VPS37B Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for VPS37B Gene

This gene is overexpressed in Breast (17.9), Urine (9.0), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for VPS37B Gene



Protein tissue co-expression partners for VPS37B Gene

NURSA nuclear receptor signaling pathways regulating expression of VPS37B Gene:

VPS37B

SOURCE GeneReport for Unigene cluster for VPS37B Gene:

Hs.507162

mRNA Expression by UniProt/SwissProt for VPS37B Gene:

Q9H9H4-VP37B_HUMAN
Tissue specificity: Widely expressed. Expressed in macrophages and lymphocytes.

Evidence on tissue expression from TISSUES for VPS37B Gene

  • Muscle(4.2)
  • Nervous system(3.5)
  • Gall bladder(2)
  • Intestine(2)
  • Lymph node(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with VPS37B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for VPS37B Gene

Orthologs for VPS37B Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS37B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS37B 32
  • 98.23 (n)
dog
(Canis familiaris)
Mammalia VPS37B 32
  • 87.72 (n)
cow
(Bos Taurus)
Mammalia VPS37B 32
  • 86.67 (n)
rat
(Rattus norvegicus)
Mammalia Vps37b 32
  • 84.56 (n)
mouse
(Mus musculus)
Mammalia Vps37b 17 33 32
  • 83.27 (n)
oppossum
(Monodelphis domestica)
Mammalia VPS37B 33
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS37B 33
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves VPS37B 33 32
  • 74.03 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS37B 33
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vps37b 32
  • 64.26 (n)
MGC75912 32
African clawed frog
(Xenopus laevis)
Amphibia flj12750-prov 32
zebrafish
(Danio rerio)
Actinopterygii zgc:114173 32
  • 60.4 (n)
vps37b 33
  • 52 (a)
OneToMany
VPS37B (1 of 2) 33
  • 51 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003731 32
  • 48.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1115 33 32
  • 46.96 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vps-37 33
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10674 33
  • 31 (a)
OneToMany
Species where no ortholog for VPS37B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS37B Gene

ENSEMBL:
Gene Tree for VPS37B (if available)
TreeFam:
Gene Tree for VPS37B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for VPS37B: view image

Paralogs for VPS37B Gene

Paralogs for VPS37B Gene

(3) SIMAP similar genes for VPS37B Gene using alignment to 3 proteins:

  • VP37B_HUMAN
  • F5H1F6_HUMAN
  • F5H4M0_HUMAN
genes like me logo Genes that share paralogs with VPS37B: view

Variants for VPS37B Gene

Sequence variations from dbSNP and Humsavar for VPS37B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000037591 -- 122,881,894(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000090174 -- 122,874,683(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000119167 -- 122,871,930(-) G/A 5_prime_UTR_variant, intron_variant
rs1000163742 -- 122,875,029(-) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000344487 -- 122,867,910(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VPS37B Gene

Variant ID Type Subtype PubMed ID
nsv517200 CNV loss 19592680
nsv7239 OTHER inversion 18451855
nsv952498 CNV deletion 24416366

Variation tolerance for VPS37B Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VPS37B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VPS37B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS37B Gene

Disorders for VPS37B Gene

Additional Disease Information for VPS37B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for VPS37B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS37B Gene

Publications for VPS37B Gene

  1. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PMID: 15218037) Stuchell MD … Sundquist WI (The Journal of biological chemistry 2004) 2 3 4 56
  2. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PMID: 22405001) Agromayor M … Williams RL (Structure (London, England : 1993) 2012) 3 4 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. Biochemical analyses of human IST1 and its function in cytokinesis. (PMID: 19129479) Bajorek M … Sundquist WI (Molecular biology of the cell 2009) 3 4 56
  5. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PMID: 17853893) Morita E … Sundquist WI (The EMBO journal 2007) 3 4 56

Products for VPS37B Gene

Sources for VPS37B Gene